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ChemicalBook >> CAS DataBase List >>N,N-Dimethyl-4-pyrazolo[1,5-b]pyridazin-3-yl-2-pyrimidinamine

N,N-Dimethyl-4-pyrazolo[1,5-b]pyridazin-3-yl-2-pyrimidinamine

N,N-Dimethyl-4-pyrazolo[1,5-b]pyridazin-3-yl-2-pyrimidinamine Structure
N,N-Dimethyl-4-pyrazolo[1,5-b]pyridazin-3-yl-2-pyrimidinamine structure
CAS No.
2814486-79-6
Chemical Name:
N,N-Dimethyl-4-pyrazolo[1,5-b]pyridazin-3-yl-2-pyrimidinamine
Synonyms
DYRK1A inhibitor compound 11;N,N-Dimethyl-4-pyrazolo[1,5-b]pyridazin-3-yl-2-pyrimidinamine;N,N-Dimethyl-4-(pyrazolo[1,5-b]pyridazin-3-yl)pyrimidin-2-amine
CBNumber:
CB613804765
Molecular Formula:
C12H12N6
Molecular Weight:
240.26
MDL Number:
MOL File:
2814486-79-6.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 01:23:22
Request For Quotation

N,N-Dimethyl-4-pyrazolo[1,5-b]pyridazin-3-yl-2-pyrimidinamine Properties

Density 1.34±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)
solubility DMSO: Slightly soluble: 1-10 mg/ml
Ethanol: Slightly soluble: 0.1-1 mg/ml
pka 3.04±0.10(Predicted)
form Solid
color White to off-white

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319
Precautionary statements  P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

N,N-Dimethyl-4-pyrazolo[1,5-b]pyridazin-3-yl-2-pyrimidinamine price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 41715 DYRK1A Inhibitor Compound 11 ≥98% 2814486-79-6 1mg $76 2026-04-30 Buy
Cayman Chemical 41715 DYRK1A Inhibitor Compound 11 ≥98% 2814486-79-6 5mg $209 2026-04-30 Buy
Cayman Chemical 41715 DYRK1A Inhibitor Compound 11 ≥98% 2814486-79-6 10mg $343 2026-04-30 Buy
Cayman Chemical 41715 DYRK1A Inhibitor Compound 11 ≥98% 2814486-79-6 25mg $665 2026-04-30 Buy
ChemScene CS-0200379 DYRK1-IN-1 99.71% 2814486-79-6 5mg $206 2026-06-04 Buy
Product number Packaging Price Buy
41715 1mg $76 Buy
41715 5mg $209 Buy
41715 10mg $343 Buy
41715 25mg $665 Buy
CS-0200379 5mg $206 Buy

N,N-Dimethyl-4-pyrazolo[1,5-b]pyridazin-3-yl-2-pyrimidinamine Chemical Properties,Uses,Production

Uses

DYRK1-IN-1 is a highly selective and ligand-efficient DYRK1A inhibitor. DYRK1-IN-1 inhibits DYRK1A phosphorylation activity with an IC50 value of 220 nM. DYRK1-IN-1 can be used for the research of central nervous system penetrant DYRK1A chemical probe[1].

in vivo

DYRK1-IN-1 (1 mg/kg; i.v.) shows high clearance[1].

Animal Model:SpragueDawley rats[1]
Dosage:1 mg/kg (Pharmacokinetic Analysis)
Administration:I.v.
Result:High clearance was observed.

IC 50

DYRK1A: 220 nM (IC50); DYRK1A: 3 nM (Kd); DYRK1B: 56 nM (Kd)

References

[1] Henderson SH, et al. Discovery and Characterization of Selective and Ligand-Efficient DYRK Inhibitors. J Med Chem. 2021;64(15):11709-11728. DOI:10.1021/acs.jmedchem.1c01115

N,N-Dimethyl-4-pyrazolo[1,5-b]pyridazin-3-yl-2-pyrimidinamine Preparation Products And Raw materials

Raw materials

Preparation Products

N,N-Dimethyl-4-pyrazolo[1,5-b]pyridazin-3-yl-2-pyrimidinamine Suppliers

Global( 10)Suppliers
Supplier Tel Email Country ProdList Advantage
Nanjing Chemlin Chemical Co., Ltd 025-83697070 13770331960 info@chemlin.com.cn China 16305 64
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105 2881489226@qq.com China 89667 60
Zhengzhou convergence chemical co., LTD 037155153829 18003835034 3897192574@qq.com China 9982 58
Bide Pharmatech Ltd. 400-1647117 13681763483 product02@bidepharm.com China 59929 58
Suzhou Zhixin Biotechnology Co., Ltd. 0512-65118909 18100677375 sales@szzxbio.com China 1057 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11963 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 29874 58
Shanghai Anbida Biotechnology Co., Ltd. 021-61629020 18201956406 sales@ambeed.cn China 7032 58
Shanghai Fengyong Biotechnology Co., Ltd. 021-10000000 13000000000 gzj@abmole.cn China 9323 58
Supplier Advantage
Nanjing Chemlin Chemical Co., Ltd 64
Shanghai YuanYe Biotechnology Co., Ltd. 60
Zhengzhou convergence chemical co., LTD 58
Bide Pharmatech Ltd. 58
Suzhou Zhixin Biotechnology Co., Ltd. 58
Shanghai Yifei Biotechnology Co. , Ltd. 58
TargetMol Chemicals Inc. 58
Shanghai Anbida Biotechnology Co., Ltd. 58
Shanghai Fengyong Biotechnology Co., Ltd. 58

2814486-79-6(N,N-Dimethyl-4-pyrazolo[1,5-b]pyridazin-3-yl-2-pyrimidinamine)Related Search:

2-Pyrimidinamine, N-methyl-N-phenyl-4-pyrazolo[1,5-b]pyridazin-3-yl- GW780056X 2-Pyrimidinamine, N-cyclopropyl-N-methyl-4-pyrazolo[1,5-b]pyridazin-3-yl- 2-Pyrimidinamine, N-methyl-N-(3-methylphenyl)-4-pyrazolo[1,5-b]pyridazin-3-yl- 2-Pyrimidinamine, N-[4-(1-methylethyl)phenyl]-4-pyrazolo[1,5-b]pyridazin-3-yl-
NA

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N,N-Dimethyl-4-pyrazolo[1,5-b]pyridazin-3-yl-2-pyrimidinamine N,N-Dimethyl-4-(pyrazolo[1,5-b]pyridazin-3-yl)pyrimidin-2-amine DYRK1A inhibitor compound 11 2814486-79-6