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SHP2/CDK4-IN-1

SHP2/CDK4-IN-1 Structure
SHP2/CDK4-IN-1 structure
CAS No.
2924036-87-1
Chemical Name:
SHP2/CDK4-IN-1
Synonyms
SHP2/CDK4-IN-1;2-Oxa-8-azaspiro[4.5]decan-4-amine, 8-[5-[[3-chloro-2-[[5-fluoro-4-[4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl]-2-pyrimidinyl]amino]-4-pyridinyl]thio]-2-pyrazinyl]-3-methyl-, (3S,4S)-
CBNumber:
CB614133486
Molecular Formula:
C33H35ClF2N10OS
Molecular Weight:
693.21
MDL Number:
MOL File:
2924036-87-1.mol
Last updated:2026-07-27 17:00:41
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SHP2/CDK4-IN-1 Properties

Boiling point 870.103±75.00 °C(Press: 760.00 Torr)(predicted)
Density 1.533±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
pka 9.278±0.40(predicted)

SHP2/CDK4-IN-1 Chemical Properties, Uses, Production

Uses

SHP2/CDK4-IN-1 (compound 10) is an orally active and potent SHP2 and CDK4 dual inhibitor, with IC50 values of 4.3 and 18.2 nM, respectively. SHP2/CDK4-IN-1 effectively induces G0/G1 arrest to prevent the proliferation of TNBC cell lines. SHP2/CDK4-IN-1 shows significant antitumor efficacy in the EMT6 syngeneic mouse model. SHP2/CDK4-IN-1 can be used for triple-negative breast cancer (TNBC) research[1].

IC 50

CDK4: 18.2 ± 1.3 nM (IC50)

References

[1] Chen X, et al. Discovery of a Novel Src Homology-2 Domain Containing Protein Tyrosine Phosphatase-2 (SHP2) and Cyclin-Dependent Kinase 4 (CDK4) Dual Inhibitor for the Treatment of Triple-Negative Breast Cancer. J Med Chem. 2022 May 12;65(9):6729-6747. DOI:10.1021/acs.jmedchem.2c00063

SHP2/CDK4-IN-1 Preparation Products And Raw materials

Raw materials

Preparation Products

SHP2/CDK4-IN-1 Suppliers

Global Suppliers ( 2)
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 29874 58
TargetMol Chemicals Inc. 13564774135 marketing@targetmol.com United States 19950 58
Supplier Advantage
TargetMol Chemicals Inc. 58
TargetMol Chemicals Inc. 58

View Latest Price from SHP2/CDK4-IN-1 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
SHP2/CDK4-IN-1 pictures 2026-07-27 SHP2/CDK4-IN-1
2924036-87-1
 $1520.00-2500.00 10g TargetMol Chemicals Inc.

2924036-87-1 (SHP2/CDK4-IN-1) Related Search:

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THZ1

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SHP2/CDK4-IN-1 2-Oxa-8-azaspiro[4.5]decan-4-amine, 8-[5-[[3-chloro-2-[[5-fluoro-4-[4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl]-2-pyrimidinyl]amino]-4-pyridinyl]thio]-2-pyrazinyl]-3-methyl-, (3S,4S)- 2924036-87-1