FGFR-IN-13
- CAS No.
- 2962941-25-7
- Chemical Name:
- FGFR-IN-13
- Synonyms
- FGFR-IN-13;2-Propenamide, N-[4-[[6-(3,5-dimethoxyphenyl)-9H-purin-9-yl]methyl]phenyl]-
- CBNumber:
- CB614257449
- Molecular Formula:
- C23H21N5O3
- Molecular Weight:
- 415.45
- MDL Number:
- MOL File:
- 2962941-25-7.mol
- MSDS File:
- SDS
FGFR-IN-13 Chemical Properties,Uses,Production
Uses
FGFR-IN-13 (compound III-30) is an irreversible covalent fibroblast growth factor receptor (FGFR) inhibitor. FGFR-IN-13 regulates endogenous FGFR1(IC50=0.20±0.02 nM) and FGFR4(IC50=0.40±0.03 nM) mediated signaling pathways by inhibiting the expression of key proteins. FGFR-IN-13 inhibits total-PARP and Bcl-2 protein expressions, and promote Cleaved-PARP and Bax protein expressions in a dose-dependent manner. FGFR-IN-13 has significant antitumor activity and oral activity[1].
in vivo
FGFR-IN-13 (10 and 30 mg/kg, po; everyday for 21 days) inhibits tumor growth in a dose-dependent manne. FGFR-IN-13 has a favorable safety profile and is effective in inhibiting tumor growth at safe doses in MDA-MB-231 xenograft tumor mouse mode[1].
| Animal Model: | MDA-MB-231 xenograft tumor mouse model[1] |
| Dosage: | 10 and 30 mg/kg |
| Administration: | Oral gavage (p.o.) |
| Result: | Did not cause significant weight loss. Achieved tumor growth inhibition (TGI) of 64.21% at high doses (30 mg/kg). Achieved tumor growth inhibition (TGI) of 40.22% at low doses (10 mg/kg). |
References
[1] Wang Y, et al. Discovery of N-(4-((6-(3, 5-Dimethoxyphenyl)-9H-Purine Derivatives as Irreversible Covalent FGFR Inhibitors[J]. European Journal of Medicinal Chemistry, 2024: 116415. DOI:10.1016/j.ejmech.2024.116415
FGFR-IN-13 Preparation Products And Raw materials
Raw materials
Preparation Products
FGFR-IN-13 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Beckham Medical Technology Co., Ltd | 13816613772 | huahero21@sina.com | China | 2996 | 55 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| Supplier | Advantage |
|---|---|
| Shanghai Beckham Medical Technology Co., Ltd | 55 |
| TargetMol Chemicals Inc. | 58 |
