Brivudine
- CAS No.
- 69304-47-8
- Chemical Name:
- Brivudine
- Synonyms
- BVDU;BVDR;BrVDU;Helpin;Brivudin;SC-38394;BRIVUDINE;Brivudine BVdU;Brivudine USP/EP/BP;Bromovinyldeoxyuridine
- CBNumber:
- CB6143433
- Molecular Formula:
- C11H13BrN2O5
- Molecular Weight:
- 333.14
- MDL Number:
- MFCD00058585
- MOL File:
- 69304-47-8.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Brivudine ≥95% | SBR00107 | 1 unit | $57.7 |
| (E)-5-(2-Bromovinyl)-2′-deoxyuridine | B9647 | 10mg | $344 |
| (E)-5-(2-Bromovinyl)-2'-deoxyuridine >98.0%(HPLC)(T) | B3404 | 100mg | $121 |
| Brivudine | 29448 | 100mg | $97 |
| Brivudine | 29448 | 1g | $530 |
| More product size | |||
| Melting point | 165°C |
|---|---|
| Density | 1.7800 (rough estimate) |
| refractive index | 1.6520 (estimate) |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 8.37±0.10(Predicted) |
| color | Off-White |
| Water Solubility | Soluble in water and methanol. |
| Merck | 14,1378 |
| InChIKey | ODZBBRURCPAEIQ-CXYVBZRVSA-N |
| NCI Dictionary of Cancer Terms | brivudine |
| FDA UNII | 2M3055079H |
| NCI Drug Dictionary | bromovinyl-deoxyuridine |
| ATC code | J05AB15 |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Safety Statements | 24/25 | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| WGK Germany | 3 | |||||||||
| RTECS | YU7355000 | |||||||||
| HS Code | 29349990 | |||||||||
| NFPA 704 |
|
Brivudine price More Price(28)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SBR00107 | Brivudine ≥95% | 69304-47-8 | 1 unit | $57.7 | 2025-07-31 | Buy |
| Sigma-Aldrich | B9647 | (E)-5-(2-Bromovinyl)-2′-deoxyuridine | 69304-47-8 | 10mg | $344 | 2025-07-31 | Buy |
| TCI Chemical | B3404 | (E)-5-(2-Bromovinyl)-2'-deoxyuridine >98.0%(HPLC)(T) | 69304-47-8 | 100mg | $121 | 2025-07-31 | Buy |
| Cayman Chemical | 29448 | Brivudine | 69304-47-8 | 100mg | $97 | 2024-03-01 | Buy |
| Cayman Chemical | 29448 | Brivudine | 69304-47-8 | 1g | $530 | 2024-03-01 | Buy |
Brivudine Chemical Properties,Uses,Production
Description
(E)-5-(2-Bromovinyl)-2'-deoxyuridine is an thymidine analogue and acts as an anti-viral by inhibiting DNA plymerase.
Chemical Properties
White solid
Uses
It is used as pharmaceutical intermediate.
Uses
Brivudine is a nucloside analog which causes induction of neuronal differentiation in human reporter cell lines and adult stem cells. Anti-Herpes medication.
Synthesis
74131-06-9
69304-47-8
GENERAL STEPS: To a solution of (E)-5-(2-carboxyvinyl)-1-(2-deoxy-β-D-erythro-pentofuranosyl)pyrimidine-2,4(1H,3H)-dione (5.777 g, 19.37 mmol) in dimethylformamide (29 mL) was added K2CO3 (5.890 g, 42.61 mmol), and the suspension was stirred at room temperature for for 15 min. A solution of N-bromosuccinimide (3.655 g, 20.53 mmol) was added dropwise over a period of 30 min at 20 °C. After completion of the reaction, the resulting suspension was filtered and the solid was washed with DMF. The combined filtrate and washings were evaporated to dryness under vacuum and the residue was dissolved in methanol. Silica gel was added to this solution, the suspension was evaporated to dryness, and the solid was loaded onto the top of the column. Column chromatography using chloroform/methanol (92:8, v/v) as eluent gave a white solid (5.787 g, 71.9% yield). A white powder was obtained by recrystallization from water. The structure of the product was confirmed by 1H-NMR and 13C-NMR: 1H-NMR (DMSO-d6; 300 MHz) δ 11.59 (1H, bs, NH-3), 8.08 (1H, s, H-6), 7.25 (1H, d, 3J = 13.6 Hz, H-5B), 6.85 (1H, d, J = 13.6 Hz, H-5A) , 6.13 (1H, t, 3J = 6.5 Hz, H-1'), 5.29 (1H, bs, OH-3'), 5.13 (1H, bs, OH-5'), 4.24 (1H, m, H-3'), 3.79 (1H, m, H-4'), 3.66 (2H, m, H-5'), 2.51 (1H, m, H-2'), 2.14 (1H, m, H-2'); 13C-NMR (DMSO-d6; 75 MHz) δ 40.2 (C-2'), 61.3 (C-5'), 70.3 (C-4'), 84.8 (C-3'), 87.8 (C-1'), 108.9 (C-5B), 110.0 (C-5), 130.3 (C-5A), 149.6 , 162.1 (c-2, c-4).
in vivo
At a dose of 125 mg once daily, brivudine has proved to be superior to aciclovir with respect to reducing the period of new blister production, and has shortened the duration of post-herpetic neuralgia[1].
References
[1] Bioorganic and Medicinal Chemistry, 2005, vol. 13, # 24, p. 6663 - 6671
[2] RSC Advances, 2015, vol. 5, # 31, p. 24558 - 24563
[3] Patent: WO2005/12327, 2005, A2. Location in patent: Page/Page column 24-25
[4] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 20, p. 5640 - 5642
[5] Patent: US6653318, 2003, B1
Brivudine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Sichuan Zhuoyu Yantang Technology Co., Ltd. | +8613288715578 | sales@sichuanzyyt.com | China | 12245 | 58 |
| Hangzhou ICH Biofarm Co., Ltd | +86-0571-28186870; +undefined8613073685410 | sales@ichemie.com | China | 1014 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29850 | 58 |
| SHANDONG ZHI SHANG CHEMICAL CO.LTD | +86 18953170293 | sales@sdzschem.com | China | 2930 | 58 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 8497 | 58 |
| Beijing Ribio Biotech Co.,Ltd | 010-62664360 +8613328773880 | wucy@ribio.com.cn | China | 117 | 58 |
| Yunbio Tech Co.,Ltd. | +86-010-60605551 +86-18046518538 | yunbiochem@126.com | China | 321 | 58 |
| Wuhan Chemwonders Technology Inc. | 027-85778276 | info@chemwonders.com | CHINA | 176 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19552 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
View Lastest Price from Brivudine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-10-27 | Brivudine
69304-47-8
|
US $55.00-98.00 / mg | 99.85% | 10g | TargetMol Chemicals Inc. | ||
 |
2025-10-27 | Brivudine
69304-47-8
|
US $55.00-98.00 / mg | 99.85% | 10g | TargetMol Chemicals Inc. | ||
 |
2025-08-08 | Brivudine
69304-47-8
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Sichuan Zhuoyu Yantang Technology Co., Ltd. |
