5-hydroxymethyl-pyrrolidine-2-one
- CAS No.
- 62400-75-3
- Chemical Name:
- 5-hydroxymethyl-pyrrolidine-2-one
- Synonyms
- pyroglutamol;DL-Pyroglutaminol;5-hydroxymethyl-pyrrolidine-2-one;2-Pyrrolidinone,5-(hydroxyMethyl)-;5-(HYDROXYMETHYL)PYRROLIDIN-2-ONE(WX640368);(5S)-5-(hydroxyMethyl)tetrahydro-1H-2-pyrrolone
- CBNumber:
- CB61459061
- Molecular Formula:
- C5H9NO2
- Molecular Weight:
- 115.13
- MDL Number:
- MFCD06661931
- MOL File:
- 62400-75-3.mol
- MSDS File:
- SDS
| Melting point | 87 °C |
|---|---|
| Boiling point | 185-187 °C(Press: 4 Torr) |
| Density | 1.153±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| pka | 14.35±0.10(Predicted) |
| Appearance | White to off-white Solid |
| optical activity | 2.3°(C=0.96 g/100ml ETOH) |
| InChI | InChI=1S/C5H9NO2/c7-3-4-1-2-5(8)6-4/h4,7H,1-3H2,(H,6,8) |
| InChIKey | HOBJEFOCIRXQKH-UHFFFAOYSA-N |
| SMILES | N1C(CO)CCC1=O |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H335-H319 |
| Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P |
5-hydroxymethyl-pyrrolidine-2-one price More Price(48)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Matrix Scientific | 135110 | 5-(Hydroxymethyl)pyrrolidin-2-one | 62400-75-3 | 1.00g | $85 | 2026-05-18 | Buy |
| Matrix Scientific | 135110 | 5-(Hydroxymethyl)pyrrolidin-2-one | 62400-75-3 | 2.50g | $165 | 2026-05-18 | Buy |
| Matrix Scientific | 135110 | 5-(Hydroxymethyl)pyrrolidin-2-one | 62400-75-3 | 5.00g | $305 | 2026-05-18 | Buy |
| Synthonix | H7102 | 5-(Hydroxymethyl)pyrrolidin-2-one 95+% | 62400-75-3 | 100mg | $15 | 2026-05-06 | Buy |
| Synthonix | H7102 | 5-(Hydroxymethyl)pyrrolidin-2-one 95+% | 62400-75-3 | 250mg | $19 | 2026-05-06 | Buy |
5-hydroxymethyl-pyrrolidine-2-one Chemical Properties, Uses, Production
Uses
5-(hydroxymethyl)-2-Pyrrolidinone is a building block and an analog of Pramanicin which induces apoptosis in human colon cancer cells. 5-(hydroxymethyl)-2-Pyrrolidinone is also available with specified stereochemistry (P997525, H948310).
Synthesis
4931-66-2
62400-75-3
Methyl 5-oxopyrrolidine-2-carboxylate (9 g, 62.93 mmol) was dissolved in methanol (150 mL) under argon protection, stirred and cooled to 0 °C. Subsequently, sodium borohydride (3.6 g, 95.2 mmol) was slowly added. The reaction mixture was gradually warmed to room temperature and stirring was continued for 2 hours. The progress of the reaction was monitored by thin layer chromatography (TLC) and after confirming the complete consumption of raw materials, the reaction mixture was quenched with concentrated hydrochloric acid at 0°C. The reaction mixture was filtered and the solid was washed with methanol (2 x 50 mL). The filtrates were combined and concentrated under reduced pressure to remove the solvent. The crude product was purified by column chromatography with 10% methanol/dichloromethane as eluent to give 5-(hydroxymethyl)pyrrolidin-2-one (6 g, 83% yield) as a colorless oil. Liquid chromatography-mass spectrometry (LCMS) analysis showed that the [M+1]+ was 116; chromatographic conditions: X-Select CSH C-18 column (50×3.0 mm, 3.5 μm); mobile phase: 5 mM aqueous ammonium acetate/acetonitrile; flow rate: 0.80 mL/min; retention time (RT): 0.44 min. Thin-layer chromatography (TLC) analysis showed that the unfolding agent was 10% methanol/dichloromethane and the Rf value was 0.3.
References
[1] Patent: WO2015/109109, 2015, A1. Location in patent: Paragraph 1239
[2] Patent: US2017/44182, 2017, A1. Location in patent: Paragraph 1804
5-hydroxymethyl-pyrrolidine-2-one Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| PharmaBlock Sciences (Nanjing),Inc. | 025-86918202 4000255188 | sales@pharmablock.com | China | 5000 | 55 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Nanjing JinruiJiuAn Biotechnology Co., Ltd. | 025-58196018 800028039 | sales@fartop.net | China | 2227 | 55 |
| Shanghai Topbiochem Technology Co., Ltd | 021-58170097 | info@topbiochem.com | China | 9513 | 58 |
| Shanghai Jian Chao Chemical Technology Co., Ltd. | 150-2103-5486 18017383231 | 983544897@qq.com | China | 9336 | 55 |
| SynAsst Chemical. | 021-60343070 | China | 12731 | 55 | |
| Shanghai Raise Chemical Technology Co.,Ltd | +86-021-50935922 | China | 7854 | 55 | |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Chengdu Firster Pharmaceutical Co., Ltd. | 028-87078428 028-87074958 | chengzhenyong@cdfirster.com | China | 2580 | 60 |
View Latest Price from 5-hydroxymethyl-pyrrolidine-2-one manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-15 | 5-hydroxymethyl-pyrrolidine-2-one
62400-75-3
|
$1.00 | 1g | 99% | 1000KGS | Career Henan Chemical Co |
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- 5-hydroxymethyl-pyrrolidine-2-one
62400-75-3
- $1.00
- 99%
- Career Henan Chemical Co
