METHYL ACETIMIDATE HYDROCHLORIDE
- CAS No.
- 14777-27-6
- Chemical Name:
- METHYL ACETIMIDATE HYDROCHLORIDE
- Synonyms
- METHYL ACETIMIDATE HCL;AcetimidicacidmethylesterHCl;METHYL ACETIMIDATE HYDROCHLORIDE;METHYL ACETIMIDATE HYDROCHLORIDE, TECH.;acetimidicacid,methylester,hydrochloride;ethanimidicacid,methylester,hydrochloride;Methyl acetiMidate hydrochloride , Technical;Methyl acetimidate hydrochloride technical grade;Ethanimidic acid, methyl ester, hydrochloride (1:1);Methyl acetimidate hydrochlorideTechnical, ≥ 99% (Assay by Titration)
- CBNumber:
- CB6146601
- Molecular Formula:
- C3H8ClNO
- Molecular Weight:
- 109.55
- MDL Number:
- MFCD00012571
- MOL File:
- 14777-27-6.mol
| Product description | Number | Pack Size | Price |
| Methyl acetimidate hydrochloride technical grade | 254940 | 25g | $620 |
| Methyl acetimidate hydrochloride technical grade | 254940 | 100g | $1610 |
| Methyl acetimidate hydrochloride | M275025 | 500mg | $45 |
| Methyl acetimidate hydrochloride 90% | OR953398 | 5g | $131 |
| METHYL ACETIMIDATE HYDROCHLORIDE 95.00% | DYE0000520 | 1G | $490 |
| More product size | |||
| Melting point | 105 °C (dec.)(lit.) |
|---|---|
| storage temp. | 2-8°C |
| Appearance | White to off-white Solid |
| BRN | 3671581 |
| InChI | 1S/C3H7NO.ClH/c1-3(4)5-2;/h4H,1-2H3;1H |
| InChIKey | WHYJXXISOUGFLJ-UHFFFAOYSA-N |
| SMILES | Cl.COC(C)=N |
| FDA UNII | 05I74I2UQ2 |
| EPA Substance Registry System | Ethanimidic acid, methyl ester, hydrochloride (14777-27-6) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 |
| target organs | Respiratory system |
| PPE | dust mask type N95 (US), Eyeshields, Gloves |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| RIDADR | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | AK2950000 |
| F | 10-21 |
| TSCA | TSCA listed |
| HS Code | 2929900090 |
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
METHYL ACETIMIDATE HYDROCHLORIDE price More Price(11)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 254940 | Methyl acetimidate hydrochloride technical grade | 14777-27-6 | 25g | $620 | 2025-07-31 | Buy |
| Sigma-Aldrich | 254940 | Methyl acetimidate hydrochloride technical grade | 14777-27-6 | 100g | $1610 | 2023-01-07 | Buy |
| TRC | M275025 | Methyl acetimidate hydrochloride | 14777-27-6 | 500mg | $45 | 2021-12-16 | Buy |
| Apolloscientific | OR953398 | Methyl acetimidate hydrochloride 90% | 14777-27-6 | 5g | $131 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | DYE0000520 | METHYL ACETIMIDATE HYDROCHLORIDE 95.00% | 14777-27-6 | 1G | $490 | 2021-12-16 | Buy |
METHYL ACETIMIDATE HYDROCHLORIDE Chemical Properties,Uses,Production
Chemical Properties
White to yellow powder
Uses
Methyl acetimidate hydrochloride has been used in pre-crystallization chemical modification of lysine residues.
General Description
Methyl acetimidate hydrochloride is an inhibitor of N-methylation of phosphatidylethanolamine. It also prevents the stimulation of purified cardiac sarcolemmal vesicles Ca2+-pump activities.
Synthesis
67-56-1
75-05-8
14777-27-6
1) Example 1-1: Preparation of methyl acetimidate hydrochloride 1.6 kg of acetonitrile and 2.4 kg of methanol were added to the reactor and the reaction system was cooled to -10 °C. 3.67 kg of acetyl chloride was slowly added dropwise with stirring, and the rate of dropwise acceleration was controlled to maintain the reaction temperature at 0 °C. After the dropwise addition, the reaction mixture was continued to be stirred at room temperature for 12 hours. After completion of the reaction, the volatile solvent was removed by distillation under reduced pressure at 45 °C. To the residue was added 11.8 kg of tert-butyl methyl ether and stirred at room temperature for 3 hours to promote crystallization. The precipitated solid product was collected by filtration and dried under vacuum at 40 °C to give 4.1 kg of methylglyoxylate hydrochloride (yield: 95%). The product was characterized by 1H-NMR (400 MHz, DMSO-d6): δ 11.7 (s, 2H), 4.07 (s, 3H), 2.38 (s, 3H).
Purification Methods
Crystallise the imidate from methanol by adding dry ether to a ratio of 1:1 and cooling at 0o. Filter off the crystals in a cold room, wash them with methanol/ether (1:2), then dry in a vacuum. [Hunter & Ludwig J Am Chem Soc 84 3491 1962.] The free base has b 90-91o/765mm, d 0.867, n 1.403. [Hunter & Ludwig Methods Enzymol 25 585 1973, Beilstein 2 IV 181.]
References
[1] Journal of Organic Chemistry, 1986, vol. 51, # 26, p. 5111 - 5123
[2] Patent: WO2015/5615, 2015, A1. Location in patent: Paragraph 138; 139; 140
[3] Chemische Berichte, 1985, vol. 118, # 8, p. 3089 - 3104
[4] Analytical Chemistry, 2006, vol. 78, # 18, p. 6398 - 6403
[5] Synlett, 2001, # 11, p. 1707 - 1710
METHYL ACETIMIDATE HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29735 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Nanjing jinheyou Trading Co., Ltd. | 15705188088 | admin@jheyou.com | CHINA | 1268 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49977 | 58 |
| Jinan Liheng Biotechnology Co., Ltd. | 15865262812 | info@lihengpharm.com | CHINA | 938 | 58 |
| Neostar United (Changzhou) Industrial Co., Ltd. | +86-0519-85551759 +8613506123987 | marketing1@neostarunited.com | China | 8830 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52846 | 58 |
| PT CHEM GROUP LIMITED | +86-85511178; | peter68@ptchemgroup.com | China | 35425 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +86-571-86217390; +8618058761490 | info@gihichemicals.com | China | 49964 | 58 |
View Lastest Price from METHYL ACETIMIDATE HYDROCHLORIDE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2019-11-08 | METHYL ACETIMIDATE HYDROCHLORIDE
14777-27-6
|
US $0.00 / g | 1g | 98%min | 20kg/month | Nanjing jinheyou Trading Co., Ltd. |
-
- METHYL ACETIMIDATE HYDROCHLORIDE
14777-27-6
- US $0.00 / g
- 98%min
- Nanjing jinheyou Trading Co., Ltd.
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