6-CHLORO-2,3-DIOXO-1,2,3,4-TETRAHYDROQUINOXALINE
- CAS No.
- 6639-79-8
- Chemical Name:
- 6-CHLORO-2,3-DIOXO-1,2,3,4-TETRAHYDROQUINOXALINE
- Synonyms
- 6-CHLOROQUINOXAZALONE;6-CHLOROQUINOXALINE-2,3-DIOL;6-Chloro-2,3-dihydroxyqunoxaline;2,3-DIHYDROXY-6-CHLOROQUINOXALINE;6-Chloro-2,3-dihydroxyquinoxaline;1-(2-chloroethoxy)-2-phenylbenzene;2,3-Dihydroxy-6-chloroquinoxaline ,97%;6-chloro-1,4-dihydro-3-quinoxalinedione;6-CHLORO-1,4-DIHYDRO-2,3-QUINOXALINEDIONE;6-chloro-1,4-dihydroquinoxaline-2,3-dione
- CBNumber:
- CB6148463
- Molecular Formula:
- C8H5ClN2O2
- Molecular Weight:
- 196.59
- MDL Number:
- MFCD00047592
- MOL File:
- 6639-79-8.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 6-Chloro-quinoxaline-2,3-diol 95%+ | ACI-01330 | 500mg | $160.65 |
| 6-Chloro-quinoxaline-2,3-diol 95%+ | ACI-01330 | 1g | $253.8 |
| 6-Chloro-quinoxaline-2,3-diol 95%+ | ACI-01330 | 5g | $835.65 |
| 6-Chloroquinoxaline-2,3-diol 95+% | CD11076471 | 5g | $101 |
| 6-Chloroquinoxaline-2,3-diol 95+% | CD11076471 | 10g | $188 |
| More product size | |||
| Melting point | >350 °C(Solv: ethanol (64-17-5)) |
|---|---|
| Density | 1.475±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| pka | 9.59±0.20(Predicted) |
| form | Solid |
| Appearance | Brown to dark brown Solid |
| InChI | InChI=1S/C8H5ClN2O2/c9-4-1-2-5-6(3-4)11-8(13)7(12)10-5/h1-3H,(H,10,12)(H,11,13) |
| InChIKey | RNOLFZACEWWIHP-UHFFFAOYSA-N |
| SMILES | N1C2=C(C=C(Cl)C=C2)NC(=O)C1=O |
| EPA Substance Registry System | 2,3-Quinoxalinedione, 6-chloro-1,4-dihydro- (6639-79-8) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P280-P302+P352-P305+P351+P338-P261 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| TSCA | TSCA listed |
| HS Code | 29334900 |
6-CHLORO-2,3-DIOXO-1,2,3,4-TETRAHYDROQUINOXALINE price More Price(31)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Acints | ACI-01330 | 6-Chloro-quinoxaline-2,3-diol 95%+ | 6639-79-8 | 500mg | $160.65 | 2026-05-20 | Buy |
| Acints | ACI-01330 | 6-Chloro-quinoxaline-2,3-diol 95%+ | 6639-79-8 | 1g | $253.8 | 2026-05-20 | Buy |
| Acints | ACI-01330 | 6-Chloro-quinoxaline-2,3-diol 95%+ | 6639-79-8 | 5g | $835.65 | 2026-05-20 | Buy |
| Crysdot | CD11076471 | 6-Chloroquinoxaline-2,3-diol 95+% | 6639-79-8 | 5g | $101 | 2026-05-20 | Buy |
| Crysdot | CD11076471 | 6-Chloroquinoxaline-2,3-diol 95+% | 6639-79-8 | 10g | $188 | 2026-05-20 | Buy |
6-CHLORO-2,3-DIOXO-1,2,3,4-TETRAHYDROQUINOXALINE Chemical Properties,Uses,Production
Chemical Properties
Off-white solid
Uses
6-Chloroquinoxaline-2,3-diol can be used as glycine receptor antagonists to use as analgesics, anticonvulsants, neuroprotectants, and sedative-hypnotics.
Synthesis
95-83-0
95-92-1
6639-79-8
Step 1: Synthesis of 6-chloroquinoxaline-2,3(1H,4H)-dione To a 100 mL round bottom flask was added 4-chloro-1,2-phenylenediamine (5.3 g, 37 mmol) and diethyl oxalate (31 mL). The reaction mixture was stirred under reflux conditions overnight. The reaction progress was monitored by thin layer chromatography (TLC, spreading agent ratio ethyl acetate/petroleum ether = 1:10). Upon completion of the reaction, the precipitate was collected by filtration, washed with ethanol (20 mL) and dried to give 7.0 g of light yellow solid product in 96% yield. The product was characterized as follows: 1H NMR (300 MHz, DMSO-d6) δ: 11.96 (br, 2H), 7.11 (m, 3H); MS m/z: 195 (M-H+).
References
[1] Journal of Medicinal Chemistry, 1990, vol. 33, # 8, p. 2240 - 2254
[2] Patent: US2010/120741, 2010, A1. Location in patent: Page/Page column 17
[3] Patent: WO2011/112731, 2011, A2. Location in patent: Page/Page column 66
[4] Journal of Organic Chemistry, 2017, vol. 82, # 19, p. 10077 - 10091
[5] Synthetic Communications, 2004, vol. 34, # 8, p. 1349 - 1357
6-CHLORO-2,3-DIOXO-1,2,3,4-TETRAHYDROQUINOXALINE Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +8613336195806 | sales@capot.com | China | 29640 | 60 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30225 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52705 | 58 |
| Aromsyn Co., Ltd. | +86-0571-85585865 +8613336024896 | CB@aromsyn.com | China | 19183 | 58 |
| Hongxiong | +undefined18915499068 | Suzhouhongxiong@163.com | China | 120 | 58 |
| PT CHEM GROUP LIMITED | +86-85511178; | peter68@ptchemgroup.com | China | 35425 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
