Carebastine-d5
- CAS No.
- 1189661-02-6
- Chemical Name:
- Carebastine-d5
- Synonyms
- Carebastine-d5;Valine Impurity 136;4-[4-[4-(DiphenylMethoxy-d5)-1-piperidinyl]-1-oxobutyl]-α,α-diMethylbenzeneacetic Acid;4-[4-[4-(Diphenylmethoxy-d5)-1-piperidinyl]-1-oxobutyl]-a,a-dimethylbenzeneacetic Acid;4-[4-[4-(Diphenylmethoxy-d5)-1-piperidinyl]-1-oxobutyl]-α,a-dimethylbenzeneacetic Acid
- CBNumber:
- CB61565757
- Molecular Formula:
- C32H37NO4
- Molecular Weight:
- 499.64048
- MDL Number:
- MFCD11977981
- MOL File:
- 1189661-02-6.mol
- MSDS File:
- SDS
Carebastine-d5 price More Price(10)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 30755 | Carebastine-d5 ≥99%deuteratedforms(d1-d5) | 1189661-02-6 | 1mg | $303 | 2026-04-30 | Buy |
| TRC | TRC-C183442-1MG | Carebastine-d5 | 1189661-02-6 | 1mg | $310 | 2026-06-03 | Buy |
| TRC | TRC-C183442-10MG | Carebastine-d5 | 1189661-02-6 | 10mg | $2288 | 2026-06-03 | Buy |
| Usbiological | 005778 | Carebastine-d5 | 1mg | $502 | 2026-06-03 | Buy | |
| TRC | C183442 | Carebastine-d5 | 1189661-02-6 | 1mg | $220 | 2021-12-16 | Buy |
Carebastine-d5 Chemical Properties, Uses, Production
Description
Carebastine-d5 is intended for use as an internal standard for the quantification of carebastine by GC- or LC-MS. Carebastine is an active metabolite of ebastine and a histamine H1 receptor antagonist (Ki = 75.86 nM). It inhibits histamine-induced contraction of isolated guinea pig trachea (IC50 = 120 nM). It also inhibits histamine release from isolated rat peritoneal mast cells and human basophils when used at concentrations ranging from 30 to 100 μM. Carebastine decreases production of chemokine (C-C motif) ligand 5 (CCL5) and CCL2 in human nasal epithelial cells isolated from patients with nasal allergies.
Chemical Properties
Off-White Solid
Uses
The active labelled carboxylic acid metabolite of Ebastine.
IC 50
H1 Receptor
References
[1] J. VINCENT. The pharmacokinetics, antihistamine and concentration-effect relationship of ebastine in healthy subjects.[J]. British journal of clinical pharmacology, 1988, 26 5: 497-502. DOI: 10.1111/j.1365-2125.1988.tb05288.x
[2] KWANG-HYEON LIU. Characterization of ebastine, hydroxyebastine, and carebastine metabolism by human liver microsomes and expressed cytochrome P450 enzymes: major roles for CYP2J2 and CYP3A.[J]. Drug Metabolism and Disposition, 2006, 34 11: 1793-1797. DOI: 10.1124/dmd.106.010488
[3] SHIGERU HISHINUMA . Asp73-dependent and -independent regulation of the affinity of ligands for human histamine H1 receptors by Na+[J]. Biochemical pharmacology, 2017, 128: Pages 46-54. DOI: 10.1016/j.bcp.2016.12.021
[4] I YAKUO. [Pharmacological study of ebastine, a novel histamine H1-receptor antagonist].[J]. Folia Pharmacologica Japonica, 1994, 103 3: 121-135. DOI: 10.1254/fpj.103.121
[5] YOKO YAMAUCHI Tatsuo S Terumichi Fujikura. The Effect of H1 Antagonists Carebastine and Olopatadine on Histamine Induced Expression of CC Chemokines in Cultured Human Nasal Epithelial Cells[J]. Allergology International, 2007, 56 2: Pages 171-177. DOI: 10.2332/allergolint.o-06-446
Carebastine-d5 Preparation Products And Raw materials
Raw materials
Preparation Products
Carebastine-d5 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| Cato Research Chemicals Inc. | 020-81960175 | min.he@cato-chem.com | China | 1949 | 55 |
| Energy Chemical | 400-0056266 | marketing1@energy-chemical.com | China | 44927 | 58 |
| Foshan Treasure Biotechnology Co., Ltd | 0757-85921206 18520245316 | 2329783215@qq.com | China | 12649 | 58 |
| ChemeGen | 18818260767 | 2625930290@qq.com | China | 6966 | 58 |
| LGC Science (Shanghai) Ltd. | 17717235263 | offer.de@lgcgroup.com | China | 19036 | 58 |
| Shanghai Yiyan Biotechnology Co. , Ltd. | 021-69985186 13611928337 | 3427709316@qq.com | China | 7982 | 58 |
| CHINA ISOTOPE CO., LIMITED | 02151600108 13062666369 | info@isotopechem.com | China | 4721 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11963 | 58 |
| Nanjing Shizhou Biology Technology Co.,Ltd | 17301488900 | judy.xia@synzest.com | China | 12577 | 58 |
