Description
Surfactant protein B (SP-B) is a hydrophobic surfactant protein and member of the saposin-like family encoded by SFTBP in humans.1 Mature SP-B is a 79-amino acid peptide formed by cleavage of proSP-B that contains three intramolecular disulfide bridges, which stabilize the tertiary structure. SP-B is expressed in alveolar type II cells, functions as a homodimer formed via intermolecular disulfide bond formation, and is required for the assembly of pulmonary surfactant, as well as the formation of stable surface-active films at the air-liquid alveolar interface. Blood levels of SB-P are increased in patients with mechanical ventilation- or pulmonary edema-induced acute alveolar cell damage.1,2 Mutations in SFTBP induce SP-B deficiency, an autosomal recessive disorder in infants characterized by progressive hypoxemic respiratory failure in the first year of life.3 Cayman’s Surfactant Protein B Rabbit Monoclonal Antibody (Clone RM370) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.WARNING This product is not for human or veterinary use.
