Description
β-Actin is a cytoskeletal protein with roles in cell division, migration, and homeostasis that is encoded by ACTB in humans.1,2 It is ubiquitously expressed, localized to the cytosol, and conserved from birds to mammals. β-Actin is enriched at the leading edge of migrating cells and Actb-/- mouse embryonic fibroblasts (MEFs) exhibit decreased migration velocity, increased apoptosis, and decreased proliferation.1 Actb knockout is early embryonic lethal in mice, indicating that β-actin is essential for embryonic development. ACTBR183W and ACTBE346K gain-of-function mutations have been found in patients with deafness, developmental mutations, and juvenile-onset dystonia and neutrophil dysfunction, respectively.3 Cayman's β-Actin (N-Term) Rabbit Monoclonal Antibody - Biotinylated (Clone RM112) can be used for chromatin immunoprecipitation (ChIP), immunocytochemistry (ICC), immunohistochemistry (IHC), immunoprecipitation (IP), and Western blot (WB) applications.WARNING This product is not for human or veterinary use.
