Description
Calponin-1 is an actin binding protein and a component of smooth muscle cell (SMC) contractile machinery that is encoded by CNN1 in humans.1,2 It is a thin filament-associated protein expressed exclusively in SMCs that interacts with actin to inhibit the movement of actin and myosin, as well as the actin-activated MgATPase activity of phosphorylated myosin.3 High levels and low levels of calponin-1 are associated with low and high disease progression risk, respectively, in patients with ductal carcinoma in situ (DCIS).4 Downregulation of arterial Cnn1 expression promotes proliferation of vascular SMCs (VSMCs) in DOCA-salt hypertensive rats and a pig model of hypertension induced by aortic coarctation.2 Cayman's Calponin-1 (C-Term) Rabbit Monoclonal Antibody (Clone RM262) can be used for immunocytochemistry (ICC) and Western blot (WB) applications.WARNING This product is not for human or veterinary use.
