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4-Bromopyrazole

4-Bromopyrazole structure

CAS No.: 2075-45-8

Chemical Name:: 4-Bromopyrazole

Synonyms: 4-BROMO-1H-PYRAZOLE;DK660;93℃-96℃;NSC 522023;AKOS B001462;WLN: T5MNJ DE;4-Brompyrazole;4-BROMOPYRAZOLE;4-bromo-pyrazol;Baricitinib-001

CBNumber:: CB6158239

Molecular Formula:: C3H3BrN2

Molecular Weight:: 146.97

MDL Number:: MFCD00075602

MOL File:: 2075-45-8.mol

MSDS File:: SDS

Last updated:2026-01-13 11:23:27

Product description	Number	Pack Size	Price
4-Bromopyrazole 99%	374822	1g	$21.36
4-Bromopyrazole 99%	374822	10g	$256
4-Bromopyrazole >98.0%(GC)	B3745	5g	$30
4-Bromopyrazole >98.0%(GC)	B3745	25g	$86
4-Bromo-1H-pyrazole	B687110	1g	$110
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4-Bromopyrazole Properties

Melting point	93-96 °C (lit.)
Boiling point	250-260 °C (lit.)
Density	1.5979 (rough estimate)
refractive index	1.5260 (estimate)
storage temp.	Inert atmosphere,Room Temperature
solubility	Chloroform, DMSO, Methanol
pka	12.71±0.50(Predicted)
form	Crystalline Powder
color	White to cream
Water Solubility	Slightly soluble in water.
InChI	InChI=1S/C3H3BrN2/c4-3-1-5-6-2-3/h1-2H,(H,5,6)
InChIKey	FHZALEJIENDROK-UHFFFAOYSA-N
SMILES	N1C=C(Br)C=N1
CAS DataBase Reference	2075-45-8(CAS DataBase Reference)
EWG's Food Scores	1
FDA UNII	JCB5VB9RTA
NIST Chemistry Reference	1H-pyrazole, 4-bromo-(2075-45-8)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P305+P351+P338

target organs

Respiratory system

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-37/39

WGK Germany

RTECS

UQ6200000

HazardClass

IRRITANT

HS Code

29331990

Storage Class

11 - Combustible Solids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

NFPA 704

	1
2		0

4-Bromopyrazole price More Price(48)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	374822	4-Bromopyrazole 99%	2075-45-8	1g	$21.36	2025-07-31	Buy
Sigma-Aldrich	374822	4-Bromopyrazole 99%	2075-45-8	10g	$256	2025-07-31	Buy
TCI Chemical	B3745	4-Bromopyrazole >98.0%(GC)	2075-45-8	5g	$30	2025-07-31	Buy
TCI Chemical	B3745	4-Bromopyrazole >98.0%(GC)	2075-45-8	25g	$86	2025-07-31	Buy
TRC	B687110	4-Bromo-1H-pyrazole	2075-45-8	1g	$110	2021-12-16	Buy

Product number	Packaging	Price	Buy
374822	1g	$21.36	Buy
374822	10g	$256	Buy
B3745	5g	$30	Buy
B3745	25g	$86	Buy
B687110	1g	$110	Buy

4-Bromopyrazole Chemical Properties,Uses,Production

Chemical Properties

White to cream crystalline powder

Uses

4-Bromopyrazole can be used as starting material employed in a synthesis of 1,4′-bipyrazoles and in suzuki reaction.

Uses

As a mono substituted pyrozole, 4-Bromopyrazole can be used as Inhibitor of human liver alcohol dehydrogenase and used in mutagenicity study with the L-arabinose resistance test of Salmonella typhimurium.

General Description

4-Bromopyrazole is a pyrazole derivative. It is reported to react with titanium tetrachloride to afford binary adducts. Mutagenicity of 4-bromopyrazole has been tested using the L-arabinose forward mutation assay of Salmonella typhimurium. It is reported to inhibit the oxidative phosphorylation, the ATP^-32P exchange reaction, and energy dependent and independent calcium uptake.

Synthesis

288-13-1

2075-45-8

Step 1: 1H-pyrazole (10 g, 147 mmol) was suspended in water (150 mL) at room temperature and N-bromosuccinimide (NBS, 26.1 g, 147 mmol) was added all at once. The reaction mixture immediately turned milky white, followed by continuous stirring at room temperature for 24 hours. Upon completion of the reaction, the reaction mixture was extracted with ethyl acetate (EtOAc, 2 x 100 mL). The combined organic phases were washed sequentially with aqueous sodium carbonate (Na2CO3) and saturated saline and dried over anhydrous sodium sulfate (Na2SO4). After concentration under reduced pressure, 21.5 g of light brown oily product (100% yield) was obtained, which solidified to a solid after standing. High performance liquid chromatography (HPLC) analysis showed a main peak retention time (RT) of 0.87 min.

References

[1] Saied M. Soliman, Ahmed M.A. Badr. “Synthesis, structure and Hirshfeld analysis of the potent antimicrobial [Ag(4-bromopyrazole)2ClO4] complex.” Polyhedron 171 (2019): Pages 323-329.
[2] Shaoling Wang , Hongkun Zhao, Cunbin Du . “Solubility, solution thermodynamics and preferential solvation for 4-bromopyrazole in mixed solvents of (methanol/ethanol+ water) from T = (283.15 to 318.15) K.” Journal of Chemical Thermodynamics 112 (2017): Pages 146-154.

4-Bromopyrazole Preparation Products And Raw materials

Raw materials

Pyrazole N-Bromosuccinimide

Preparation Products

1-Methyl-4-pyrazole boronic acid pinacol ester 4-Iodopyrazole 1H-Pyrazole-4-carboxaldehyde 5-BroMo-1,2,3-triazine (R)-3-(4-broMo-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile

4-bromo-1-cyclopropyl-1H-pyrazole 1-allyl-4-bromo-1H-pyrazole 4-Bromo-1-isopentylpyrazole AKOS B023947

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4-Bromopyrazole Suppliers

Global( 483)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hubei Lidu New Material Technology Co., Ltd	+86-19307248857 +86-19307248857	19307248857@163.com	China	881	58
Shaanxi Dideu Medichem Co. Ltd	+86-029-81138252 +86-173 9270 1263	1057@dideu.com	China	3998	58
RongNa Biotechnology Co.,Ltd	+86-86-13583358881 +8618560316533	Brad@rongnabiotech.com	China	3384	58
Hebei Chuanghai Biotechnology Co,.LTD	+86-13131129325	sales1@chuanghaibio.com	China	5242	58
Hebei Chuanghai Biotechnology Co., Ltd	+8615531151365	mina@chuanghaibio.com	China	18126	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20128	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29735	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-2158073036	info@dakenam.com	China	13799	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21597	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60

Supplier	Advantage
Hubei Lidu New Material Technology Co., Ltd	58
Shaanxi Dideu Medichem Co. Ltd	58
RongNa Biotechnology Co.,Ltd	58
Hebei Chuanghai Biotechnology Co,.LTD	58
Hebei Chuanghai Biotechnology Co., Ltd	58
Henan Fengda Chemical Co., Ltd	58
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60

View Lastest Price from 4-Bromopyrazole manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-02-11	4-Bromopyrazole 2075-45-8	US $1.00 / g	1g	99%	100kg	RongNa Biotechnology Co.,Ltd
2026-02-10	4-bromo-1H-pyrazole 2075-45-8	US $1.00 / g	10000000g	99.9%	5000	.GZ HONESTCHEM CO.,LTD
2026-02-02	4-BROMOPYRAZOLE 2075-45-8	US $0.00 / kg	1kg	98%	20tons	Hubei Lidu New Material Technology Co., Ltd

4-Bromopyrazole
2075-45-8
US $1.00 / g
99%
RongNa Biotechnology Co.,Ltd

4-bromo-1H-pyrazole
2075-45-8
US $1.00 / g
99.9%
.GZ HONESTCHEM CO.,LTD

4-BROMOPYRAZOLE
2075-45-8
US $0.00 / kg
98%
Hubei Lidu New Material Technology Co., Ltd

4-Bromopyrazole Spectrum

4-Bromopyrazole(2075-45-8)¹HNMR 4-Bromopyrazole(2075-45-8)IR 4-Bromopyrazole(2075-45-8)Raman

2075-45-8(4-Bromopyrazole)Related Search:

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Bromine 4-Bromo-1,3,5-trimethyl-1H-pyrazole 3,4,5-TRIBROMO-1-(4-NITROPHENYL)-1H-PYRAZOLE

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