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(R)-3-(Boc-Amino)piperidine

(R)-3-(Boc-Amino)piperidine Structure
(R)-3-(Boc-Amino)piperidine structure
CAS No.
309956-78-3
Chemical Name:
(R)-3-(Boc-Amino)piperidine
Synonyms
Linagliptin interMediate;(R)-3-BOC-AMINOPIPERIDINE;(R)-3-(TERT-BUTOXYCARBONYLAMINO)PIPERIDINE;R-BOC;Alogliptin-1;CAS:309956-78-3;Linagliptin INT2;R-Boc-Amino-Piperidine;Linagliptin Impurity 87;alogliptin impurities14
CBNumber:
CB6169981
Molecular Formula:
C10H20N2O2
Molecular Weight:
200.28
MDL Number:
MFCD03093382
MOL File:
309956-78-3.mol
MSDS File:
SDS
Last updated:2025-09-25 17:15:13
Product description Number Pack Size Price
(R)-3-(Boc-amino)piperidine 97% 735868 1g $68.7
(R)-3-(tert-Butoxycarbonylamino)piperidine >98.0%(GC)(T) B3591 1g $46
(R)-3-(tert-Butoxycarbonylamino)piperidine >98.0%(GC)(T) B3591 5g $153
(R)-3-(Boc-amino)piperidine B621135 50g $385
(R)-3-(Boc-amino)piperidine B621135 1g $50
More product size
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(R)-3-(Boc-Amino)piperidine Properties

Melting point 121.0 to 125.0 °C
Boiling point 304.8±31.0 °C(Predicted)
Density 1.02±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility Soluble in methanol and ethanol.
pka 12.37±0.20(Predicted)
form Solid
color White to Off-White
optical activity [α]22/D +3.2°, c = 0.5 in DMF
BRN 10662518
InChI InChI=1S/C10H20N2O2/c1-10(2,3)14-9(13)12-8-5-4-6-11-7-8/h8,11H,4-7H2,1-3H3,(H,12,13)/t8-/m1/s1
InChIKey WUOQXNWMYLFAHT-MRVPVSSYSA-N
SMILES C(OC(C)(C)C)(=O)N[C@@H]1CCCNC1
CAS DataBase Reference 309956-78-3(CAS DataBase Reference)
UNSPSC Code 12352005
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
GHS05,GHS07,GHS09
Signal word  Danger
Hazard statements  H315-H318-H335-H400
Precautionary statements  P273-P280-P302+P352-P305+P351+P338+P310
Hazard Codes  Xi,N
Risk Statements  37/38-41-50
Safety Statements  26-39-61-29-36
RIDADR  3077
WGK Germany  2
HazardClass  9
PackingGroup  Ⅲ
HS Code  29333990
Limited Quantities 5.0 L (1.3 gallons) (liquid) or 5.0 kg (11 lbs) (solid)
Excepted Quantities Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)
NFPA 704
1
2 0

(R)-3-(Boc-Amino)piperidine price More Price(46)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 735868 (R)-3-(Boc-amino)piperidine 97% 309956-78-3 1g $68.7 2025-07-31 Buy
TCI Chemical B3591 (R)-3-(tert-Butoxycarbonylamino)piperidine >98.0%(GC)(T) 309956-78-3 1g $46 2025-07-31 Buy
TCI Chemical B3591 (R)-3-(tert-Butoxycarbonylamino)piperidine >98.0%(GC)(T) 309956-78-3 5g $153 2025-07-31 Buy
TRC B621135 (R)-3-(Boc-amino)piperidine 309956-78-3 50g $385 2021-12-16 Buy
TRC B621135 (R)-3-(Boc-amino)piperidine 309956-78-3 1g $50 2021-12-16 Buy
Product number Packaging Price Buy
735868 1g $68.7 Buy
B3591 1g $46 Buy
B3591 5g $153 Buy
B621135 50g $385 Buy
B621135 1g $50 Buy

(R)-3-(Boc-Amino)piperidine Chemical Properties,Uses,Production

Solubility in organics

Soluble in methanol and ethanol.

Uses

(R)-3-(Boc-amino)piperidine is Boc protected (R)-3-Aminopiperidine (A627920, Dihydrochloride salt) which has been used as a reactant for the preparation of dipeptidyl peptidase IV inhibitors derived from Alogliptin.

storage

Stable under recommended storage conditions. Incompatible with oxidizing agents.

Chemical Properties

White powder

Uses

(R)-3-(Boc-amino)piperidine is used as an organic chemical synthesis intermediate.

Synthesis

(R)-3-N-BOC-AMINO-1-CBZ-PIPERIDINE

485820-12-0

(R)-3-(Boc-Amino)piperidine

309956-78-3

General procedure for the synthesis of (R)-3-Boc-aminopiperidine from benzyl (R)-3-((tert-butoxycarbonyl)amino)piperidine-1-carboxylate: 46.8 g of benzyl (R)-3-((tert-butoxycarbonyl)amino)piperidine-1-carboxylate (Compound IV), 2.3 g of 10% wet palladium-carbon (50% water) and 320 mL of methanol were added to an autoclave. The reaction system was replaced with nitrogen 3 to 4 times and the reaction temperature was raised to 35 to 40 °C under hydrogen pressure of 0.3 to 0.4 MPa and maintained for 2 hours. The progress of the reaction was monitored by HPLC until complete conversion of the feedstock. Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated to be free of fractions. To the concentrate, 23 mL of dichloromethane and 46 mL of petroleum ether were added and the temperature was raised to 35 to 40 °C. At this temperature, 325 mL of petroleum ether was slowly added and held for 1 hour. The reaction mixture was then slowly cooled to -5~0°C and the solid product was collected by filtration. The solid was dried at 40~45°C to give 26.7 g of white solid (R)-3-Boc-aminopiperidine in 95.4% yield.

References

[1] Patent: CN105130879, 2018, B. Location in patent: Paragraph 0064; 0065; 0066; 0067; 0068; 0069; 0070
[2] Patent: WO2004/33455, 2004, A2. Location in patent: Page 27
[3] Patent: US2003/105077, 2003, A1

(R)-3-(Boc-Amino)piperidine synthesis

454713-13-4
309956-78-3
Synthesis of (R)-3-(Boc-Amino)piperidine from (R)-1-Benzyl-3-N-Boc-aminopiperidine

(R)-3-(Boc-Amino)piperidine Preparation Products And Raw materials

Raw materials

(R)-3-N-BOC-AMINO-1-CBZ-PIPERIDINE (R)-1-Benzyl-3-N-Boc-aminopiperidine Palladium Methanol Hydrogen
Activated carbon Water

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Preparation Products

(R)-3-Amino-1-methyl-piperidine

(R)-3-(Boc-Amino)piperidine Suppliers

Global( 629)Suppliers
Supplier Tel Email Country ProdList Advantage
Chongqing Ensky Pharmaceutical Co.,Ltd.
+86-23-86815286 +86-13983794297 sales@ensky-chemical.com China 92 58
Henan Bao Enluo International TradeCo.，LTD 		+86-17331933971 deasea125996@gmail.com China 2472 58
Anhui Ruihan Technology Co., Ltd 		+8617756083858 daisy@anhuiruihan.com China 973 58
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 20175 58
Handan City Zechi trading Co., LTD 		+8619003396151 13165586887@163.com China 575 58
Frapp's ChemicalNFTZ Co., Ltd. 		+86 (576) 8169-6106 sales@frappschem.com China 880 50
Capot Chemical Co.,Ltd. 		+86-（0）57185586718; +8613336195806 sales@capot.com China 29734 60
Shanghai Daken Advanced Materials Co.,Ltd 		+86-2158073036 info@dakenam.com China 13456 58
Beijing Cooperate Pharmaceutical Co.,Ltd 		010-60279497 sales01@cooperate-pharm.com CHINA 1803 55
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21620 55
Supplier Advantage
Chongqing Ensky Pharmaceutical Co.,Ltd.
58
Henan Bao Enluo International TradeCo.，LTD 		58
Anhui Ruihan Technology Co., Ltd 		58
Henan Fengda Chemical Co., Ltd 		58
Handan City Zechi trading Co., LTD 		58
Frapp's ChemicalNFTZ Co., Ltd. 		50
Capot Chemical Co.,Ltd. 		60
Shanghai Daken Advanced Materials Co.,Ltd 		58
Beijing Cooperate Pharmaceutical Co.,Ltd 		55
Henan Tianfu Chemical Co.,Ltd. 		55

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Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
(R)-3-(Boc-Amino)piperidine pictures 2025-09-28 (R)-3-(Boc-Amino)piperidine
309956-78-3
 US $1.00 / g 100g 99 1000 Handan City Zechi trading Co., LTD
(R)-3-(Boc-Amino)piperidine pictures 2025-09-26 (R)-3-(Boc-Amino)piperidine
309956-78-3
 US $480.00-460.00 / kilograms 1kilograms 99% 100000tons Hebei Dangtong Import and export Co LTD
(R)-3-(Boc-Amino)piperidine pictures 2025-09-25 (R)-3-(Boc-Amino)piperidine
309956-78-3
 US $5.00-0.10 / KG 1KG 99% g-kg-tons, free sample is available Henan Fengda Chemical Co., Ltd

(R)-3-(Boc-Amino)piperidine Spectrum

(R)-3-(Boc-Amino)piperidine(309956-78-3)1HNMR

309956-78-3((R)-3-(Boc-Amino)piperidine)Related Search:

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CARBAMIC ACID, (3R)-3-PIPERIDINYL-, 1,1-DIMETHYLETHYL ESTER (R)-TERT-BUTYL-PIPERIDINE-3-YICARBAMATE (R)-PIPERIDIN-3-YL-CARBAMIC ACID TERT-BUTYL ESTER (R)-3-AMINO-N-TBOC-PIPERIDINE tert-Butyl [(3R)-piperidin-3-yl]carbamate, (3R)-3-[(tert-Butoxycarbonyl)amino]piperidine Linagliptin interMediate B Alogliptin Benzoate interMediate F (R)-3-(Boc-amino)piperidine,97% (R)-3-(Boc-Amino)piperidine (R)-(+)-3-tert-Butoxycarbonylaminopiperidine tert-butyl N-[(3R)-piperidin-3-yl]carbamate (R)-3-(tert-Butoxycarbonylamino)piperidine (R)-(+)-3-TERT-BUTOXYCARBO (R)-3-(Tert-butyloxycarbonyl amino)piperidin Linagliptin INT2 Alogliptin-1 (R)-3-N-BOC-AMINO-PIPERIDINE (R)-3-BOC-AMINOPIPERIDINE (R)-(+)-3-TERT-BUTOXYCARBONYLAMINOPIPERIDINE (R)-3-(TERT-BUTOXYCARBONYLAMINO)PIPERIDINE (R)-3-N-BOC-AMINOPIPERIDINE HCL (r)-3-(boc-amio)piperidine (R)-3-BOC-AMINOPIPERIDINE 99% Carbamic acid, (3R)-3-piperidinyl-, 1,1-dimethylethyl ester (9CI) (R)-3-Aminopiperidine, 3-BOC protected (R)-tert-butylpiperidin-3-ylcarbamate R-1-BOC-3-aminopiperdine Carbamic acid, N-(3R)-3-piperidinyl-, 1,1-dimethylethyl ester (3R)-3-Aminopiperidine, 3-BOC protected (R)-tert-butyl piperidin-3-ylcarbamate hydrochloride tert-Butyl (3R)-piperidin-3-ylcarbamate (R)-3-(Boc-aMino)piperidi... (R)-3-Boc-aMinopiperidineaMinopiperidine (R)-3-tert-butyloxycarbonylaMino-piperidine Linagliptin interMediate (R)-3-(tert-Butoxycarbonylamino)piperidine > ert-butylN-[(3R)-piperidin-3-yl]carbamate (R)-3-(Boc-Amino)piperidine ISO 9001：2015 REACH Linagliptin intermediates，(R)-3-(Boc-Amino)piperidine Linagliptin Impurity 87 alogliptin impurities161 (3R)-3-[(tert-Butoxycarbonyl)amino]piperidine alogliptin impurities14 (R)-3-Boc-aminopiperidineQ: What is (R)-3-Boc-aminopiperidine Q: What is the CAS Number of (R)-3-Boc-aminopiperidine Q: What is the storage condition of (R)-3-Boc-aminopiperidine R-BOC tert-butyl N-[(3R)-3-piperidyl]carbamate 1,1-Dimethylethyl N-(3R)-3-piperidinylcarbamate Linagliptin intermediate (R)-(+)-3-tert-Butoxycarbonylaminopiperidine (R) -3-Boc aminopyridine R-Boc-Amino-Piperidine BOC-R-3-AMINOPIPERIDINE (R)-3-Boc-aminopiperidine (Alogliptin Impurity) CAS:309956-78-3 (R)-3-(Boc-amino)piperidine 309956-78-3 Piperidine Series N-BOC pharmacetical Piperidine