Chloromethyl pivalate
- CAS No.
- 18997-19-8
- Chemical Name:
- Chloromethyl pivalate
- Synonyms
- POM-CL;PIVALOYLOXYMETHYL CHLORIDE;Chloromethyl 2,2-dimethylpropanoate;CMPV;Adefovir Impurity 13;hloromethyl pivalate;chloromethylepivalate;CHLOROMETHYL PIVALATE;CHLOROMETHYL PIVARATE;Pivaloxymethylchlorde
- CBNumber:
- CB6171175
- Molecular Formula:
- C6H11ClO2
- Molecular Weight:
- 150.6
- MDL Number:
- MFCD00000884
- MOL File:
- 18997-19-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Chloromethyl pivalate 97% | 141186 | 25g | $60.9 |
| Chloromethyl pivalate 97% | 141186 | 100g | $96 |
| Chloromethyl Pivalate [Amino-Protecting Agent] >99.0%(GC) | P1012 | 25g | $26 |
| Chloromethyl Pivalate [Amino-Protecting Agent] >99.0%(GC) | P1012 | 100g | $66 |
| Chloromethyl Pivalate [Amino-Protecting Agent] >99.0%(GC) | P1012 | 500g | $205 |
| More product size | |||
| Melting point | <-40°C |
|---|---|
| Boiling point | 146-148 °C (lit.) |
| Density | 1.045 g/mL at 25 °C (lit.) |
| refractive index |
n |
| Flash point | 104 °F |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | Chloroform (Slightly), Ethyl Acetate (Sparingly) |
| form | Liquid |
| Specific Gravity | 1.038 |
| color | Clear colorless to slightly yellow |
| Water Solubility | Miscible with most organic solvents. Immiscible with water. |
| BRN | 1560838 |
| InChI | 1S/C6H11ClO2/c1-6(2,3)5(8)9-4-7/h4H2,1-3H3 |
| InChIKey | GGRHYQCXXYLUTL-UHFFFAOYSA-N |
| SMILES | CC(C)(C)C(=O)OCCl |
| CAS DataBase Reference | 18997-19-8(CAS DataBase Reference) |
| FDA UNII | ZQU16YZ6MF |
| NIST Chemistry Reference | Propanoic acid, 2,2-dimethyl-, chloromethyl ester(18997-19-8) |
| EPA Substance Registry System | Propanoic acid, 2,2-dimethyl-, chloromethyl ester (18997-19-8) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H226-H302+H312+H332-H315-H319-H335 | |||||||||
| Precautionary statements | P210-P280-P301+P312-P303+P361+P353-P304+P340+P312-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 10-20/21/22-36/37/38 | |||||||||
| Safety Statements | 16-26-36-41-36/37/39 | |||||||||
| RIDADR | UN 3272 3/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | 3 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29159000 | |||||||||
| Storage Class | 3 - Flammable liquids | |||||||||
| Hazard Classifications | Acute Tox. 4 Dermal Acute Tox. 4 Inhalation Acute Tox. 4 Oral Eye Irrit. 2 Flam. Liq. 3 Skin Irrit. 2 STOT SE 3 |
|||||||||
| Limited Quantities | 5.0 L (1.3 gallons) (liquid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) | |||||||||
| NFPA 704 |
|
Chloromethyl pivalate price More Price(25)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 141186 | Chloromethyl pivalate 97% | 18997-19-8 | 25g | $60.9 | 2026-03-19 | Buy |
| Sigma-Aldrich | 141186 | Chloromethyl pivalate 97% | 18997-19-8 | 100g | $96 | 2026-03-19 | Buy |
| TCI Chemical | P1012 | Chloromethyl Pivalate [Amino-Protecting Agent] >99.0%(GC) | 18997-19-8 | 25g | $26 | 2026-03-19 | Buy |
| TCI Chemical | P1012 | Chloromethyl Pivalate [Amino-Protecting Agent] >99.0%(GC) | 18997-19-8 | 100g | $66 | 2026-03-19 | Buy |
| TCI Chemical | P1012 | Chloromethyl Pivalate [Amino-Protecting Agent] >99.0%(GC) | 18997-19-8 | 500g | $205 | 2026-03-19 | Buy |
Chloromethyl pivalate Chemical Properties,Uses,Production
Chemical Properties
Clear colorless to slightly yellow liquid
Uses
Chloromethyl pivalate was used in the synthesis of pivaloyloxy methyl ester of ofloxacin as prodrug. It was used as the reagent during the synthesis of an isoindoline-annulated, tricyclic sultam library via microwave-assisted, continuous-flow organic synthesis.
Application
Chloromethyl pivalate is a pharmaceutical intermediate compound used in the synthesis of active pharmaceutical ingredients. It is also involved in the acylation reaction with 9-(2-phosphonomethoxyethyl)adenine. It is used as a protecting agent for the N-protection of amines. It is also used in the preparation of thivaloyloxymethyl ester of ofloxacin as a prodrug. It is also used in the preparation of sulbactam pivoxil by reaction with the sodium salt of sulbactam. Besides, it is used as a reagent in the synthesis of isoindoline cyclic and continuous flow organic synthesis.
General Description
Chloromethyl pivalate reacts with sodium salt of sulbactam to yield sulbactam pivoxil. It undergoes acylation reaction with 9-(2-phosphonylmethoxyethyl)adenine (PMEA) to yield bis(pivaloyloxymethyl) PMEA.
Synthesis
Chloromethyl pivalate is prepared by the reaction of formaldehyd and pivaloyl chloride. The specific synthesis steps are as follows:
A mixture of pivaloyl chloride (8.56 g, 71 mmol), paraformaldehyde (2.13 g, 71 mmol) and zinc chloride (75 mg, 0.55 mmol) was stirred at 80 °C for 2 h. Purification by vacuum distillation afforded chloromethyl pivalate (41) as a colourless oil (6.29 g, 44.7 mmol, 59%). bp 80 °C/15 mmHg [lit.1 bp 80-81 °C/15 mmHg]; 1H NMR (400 MHz, CDCl3) δ 1.24 (9H, s, tBu), 5.72 (2H, s, CH2).
References
[1] Synthetic Communications, 1995, vol. 25, # 18, p. 2739 - 2749
[2] Bioorganic and Medicinal Chemistry, 2012, vol. 20, # 13, p. 3997 - 4011
[3] Patent: WO2013/133726, 2013, A1. Location in patent: Page/Page column 76
[4] Tetrahedron Letters, 1989, vol. 30, # 51, p. 7141 - 7144
[5] Journal of Pharmaceutical Sciences, 1994, vol. 83, # 9, p. 1269 - 1273
Chloromethyl pivalate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Handan Huajun chemicals Co.,Ltd | +86-0310-+86-0310-8166573 +8618630058311 | sales@huajunchem.com | China | 37 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8738 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8618531123677 | faithe@yan-xi.com | China | 5853 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531151365 | mina@chuanghaibio.com | China | 18126 | 58 |
| Hebei Zhuanglai Chemical Trading Co.,Ltd | +8613343047651 | admin@zlchemi.com | China | 3692 | 58 |
| Shanghai Bojing Chemical Co.,Ltd. | +86-86-02137122233 +8613795318958 | bj1@bj-chem.com | China | 299 | 55 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21592 | 55 |
| Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8617317452075 | jack.li@time-chemicals.com | China | 1803 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29821 | 58 |
| Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14332 | 58 |
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- Mar 2，2026
View Lastest Price from Chloromethyl pivalate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2026-04-24 | Chloromethyl pivalate
18997-19-8
|
US $13.00 / kg | 1kg | 99.0% | 500MT | Handan Huajun chemicals Co.,Ltd | |
 |
2026-03-20 | Chloromethyl pivalate
18997-19-8
|
US $10.00 / KG | 1KG | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2025-06-27 | Chloromethyl pivalate
18997-19-8
|
US $0.00-0.00 / KG | 1KG | 99% | 500000kg | Hebei Chuanghai Biotechnology Co., Ltd |
-
- Chloromethyl pivalate
18997-19-8
- US $13.00 / kg
- 99.0%
- Handan Huajun chemicals Co.,Ltd
-
- Chloromethyl pivalate
18997-19-8
- US $10.00 / KG
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- Chloromethyl pivalate
18997-19-8
- US $0.00-0.00 / KG
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
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