Description
Histone 3 is a nuclear protein and a component of the nucleosome core, a basic unit of chromatin, that is essential for organizing genomic DNA in eukaryotic nuclei.1 It is a globular protein that contains a histone fold domain with a C-terminal α-helix that facilitates nucleosome interactions and chromatin compaction, as well as an unstructured N-terminal tail that extends outside of the nucleosome core, both of which are subject to various post-translational modifications (PTMs), including ubiquitination, acetylation, methylation, and phosphorylation.1,2,3 Histone H3 has a key role in transcriptional regulation.4 Expression of histone H3.3, a subtype of histone 3, containing a lysine-to-methionine substitution at residue 4 (H3.3K4M) decreases the levels of histone H3K4Me1 and H3K4Me3 in primary mouse cortical neurons.5 Cayman's Histone H3 K4M Mutant Rabbit Monoclonal Antibody - Biotinylated (Clone RM363) can be used for ELISA, immunohistochemistry (IHC), and Western blot (WB) applications.WARNING This product is not for human or veterinary use.
