5-Bromo-2-chloropyridine
- CAS No.
- 53939-30-3
- Chemical Name:
- 5-Bromo-2-chloropyridine
- Synonyms
- N-methyl-1-(pyridin-3-yl)methanamine;CL025;2-CHLORO-5-BROMOPYRIDINE;5-BROMO-2-CHLOROPYRIDINE;3-Bromo-6-chloropyridine;2-cholro-5-broMopyridine;5-Bromo-2-chloro pyridne;5-bromo-2-chlorolpyridine;PYRIDINE, 5-BROMO-2-CHLORO-;2-chloro -5-pyridyl broMide
- CBNumber:
- CB6177511
- Molecular Formula:
- C5H3BrClN
- Molecular Weight:
- 192.44
- MDL Number:
- MFCD01318951
- MOL File:
- 53939-30-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 5-Bromo-2-chloropyridine 95% | 551902 | 25g | $115 |
| 5-Bromo-2-chloropyridine 95% | 551902 | 5g | $55.7 |
| 5-Bromo-2-chloropyridine >98.0%(GC) | B2329 | 5g | $25 |
| 5-Bromo-2-chloropyridine >98.0%(GC) | B2329 | 25g | $99 |
| 5-BROMO-2-CHLOROPYRIDINE 97% | 21554 | 25G | $25 |
| More product size | |||
| Melting point | 65-69 °C (lit.) |
|---|---|
| Boiling point | 208.1±20.0 °C(Predicted) |
| Density | 1.7783 (rough estimate) |
| refractive index | 1.5400 (estimate) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| pka | -2.25±0.10(Predicted) |
| form | Crystalline Powder or Crystals |
| color | Off-white |
| BRN | 108887 |
| InChI | InChI=1S/C5H3BrClN/c6-4-1-2-5(7)8-3-4/h1-3H |
| InChIKey | PEAOEIWYQVXZMB-UHFFFAOYSA-N |
| SMILES | C1(Cl)=NC=C(Br)C=C1 |
| CAS DataBase Reference | 53939-30-3(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36-37/39-36/37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Irritant | |||||||||
| TSCA | T | |||||||||
| HazardClass | IRRITANT, IRRITANT-HARMFUL | |||||||||
| HS Code | 29333990 | |||||||||
| NFPA 704 |
|
5-Bromo-2-chloropyridine price More Price(45)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 551902 | 5-Bromo-2-chloropyridine 95% | 53939-30-3 | 25g | $115 | 2026-04-30 | Buy |
| Sigma-Aldrich | 551902 | 5-Bromo-2-chloropyridine 95% | 53939-30-3 | 5g | $55.7 | 2023-06-20 | Buy |
| TCI Chemical | B2329 | 5-Bromo-2-chloropyridine >98.0%(GC) | 53939-30-3 | 5g | $25 | 2026-04-30 | Buy |
| TCI Chemical | B2329 | 5-Bromo-2-chloropyridine >98.0%(GC) | 53939-30-3 | 25g | $99 | 2026-04-30 | Buy |
| AstaTech | 21554 | 5-BROMO-2-CHLOROPYRIDINE 97% | 53939-30-3 | 25G | $25 | 2026-04-30 | Buy |
5-Bromo-2-chloropyridine Chemical Properties,Uses,Production
Chemical Properties
Light yellow Cryst
Uses
5-Bromo-2-chloropyridine may be used in the preparation of following compounds:
- Amino-2-chloropyridine via palladium-catalyzed amination.
- 5-Bromo-2-fluoropyridine via halogen-exchange reaction using anhydrous potassium fluoride.
- 2-Chloro-5-(2,5-dimethoxyphenyl)pyridine via Suzuki coupling with 2,5-dimethoxyphenylboronic acid.
Synthesis
6-Chloro-pyridin-3-ylamine was dissolved slowly with constant stirring in 48% HBr solution (50 mL) at r.t. and then the solution was cooled to -10 °C. A solution of sodium nitrite in cold water was added dropwise at -10 °C with constant stirring over 2 h, followed by a solution of copper (I) bromide in 48% HBr dropwise. The mixture was then stirred at r.t. until complete. The mixture was neutralized with sodium carbonate and extracted with ethyl acetate. The organic phase was washed with brine, dried over sodium sulfate, and concentrated. The residue was purified by column chromatography on silica gel (60-120 mesh) eluting with 1% ethyl acetate/petroleum ether to afford 5- bromo-2-chloropyridine.
References
[1] Journal of Medicinal Chemistry, 2007, vol. 50, # 15, p. 3627 - 3644
[2] Patent: WO2008/62182, 2008, A1. Location in patent: Page/Page column 119
[3] Patent: WO2004/6922, 2004, A1. Location in patent: Page/Page column 53
[4] Zhurnal Russkago Fiziko-Khimicheskago Obshchestva, 1920, vol. 50, p. 476
[5] Chem. Zentralbl., 1923, vol. 94, # III, p. 1020
5-Bromo-2-chloropyridine Preparation Products And Raw materials
Raw materials
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Preparation Products
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| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8738 | 58 |
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 | deasea125996@gmail.com | China | 2472 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20124 | 58 |
| Frapp's ChemicalNFTZ Co., Ltd. | +86 (576) 8169-6106 | sales@frappschem.com | China | 880 | 50 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29640 | 60 |
| Hi-Tech Chemistry Corp | 0519-86626038 | yuhh@hitechem.com | CHINA | 810 | 58 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3009 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29819 | 58 |
| Zhejiang ZETian Fine Chemicals Co. LTD | +8618957127338 | stella@zetchem.com | China | 2994 | 58 |
View Lastest Price from 5-Bromo-2-chloropyridine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-03-20 | 2-Chloro-5-bromopyridine
53939-30-3
|
US $1.00 / kg | 1kg | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2025-12-01 | 5-Bromo-2-chloropyridine
53939-30-3
|
US $0.00-0.00 / KG | 1KG | 99.0% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd | |
 |
2025-11-18 | 5-Bromo-2-chloropyridine
53939-30-3
|
US $1.10 / g | 1g | 99.00% | 100 Tons min | Dideu Industries Group Limited |
-
- 2-Chloro-5-bromopyridine
53939-30-3
- US $1.00 / kg
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- 5-Bromo-2-chloropyridine
53939-30-3
- US $0.00-0.00 / KG
- 99.0%
- Shaanxi Dideu New Materials Co. Ltd
-
- 5-Bromo-2-chloropyridine
53939-30-3
- US $1.10 / g
- 99.00%
- Dideu Industries Group Limited
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