2-Ethoxybenzonitrile
- CAS No.
- 6609-57-0
- Chemical Name:
- 2-Ethoxybenzonitrile
- Synonyms
- Ethoxybenzonitril;O-ETHOXYBENZONITRILE;2-ETHOXYBENZONITRILE;2-Ethoxybenzonitrile>Benzonitrile, 2-ethoxy-;O-ETHOXYBENZONITRILE 95%;2-ETHOXYBENZONITRILE 98%;2-Ethoxybenzonitrile o-Ethoxybenzonitrile
- CBNumber:
- CB6205010
- Molecular Formula:
- C9H9NO
- Molecular Weight:
- 147.17
- MDL Number:
- MFCD00001789
- MOL File:
- 6609-57-0.mol
| Product description | Number | Pack Size | Price |
| 2-Ethoxybenzonitrile 98% | 283576 | 1g | $93.6 |
| 2-Ethoxybenzonitrile >98.0%(GC) | E0968 | 5g | $35 |
| 2-Ethoxybenzonitrile >98.0%(GC) | E0968 | 25g | $107 |
| 2-Ethoxybenzonitrile | E891333 | 250mg | $45 |
| 2-Ethoxybenzonitrile 98% | 003296 | 25g | $53 |
| More product size | |||
| Melting point | 5°C(lit.) |
|---|---|
| Boiling point | 154°C 20mm |
| Density | 1.053 g/mL at 25 °C (lit.) |
| vapor pressure | 0.49-54000Pa at 20-238℃ |
| refractive index |
n |
| Flash point | >230 °F |
| storage temp. | Sealed in dry,Room Temperature |
| form | Liquid |
| color | Clear colorless to pale yellow |
| LogP | 2.6 at 25℃ and pH6.6 |
| Surface tension | 54.5mN/m at 511.2mg/L and 20.1℃ |
| CAS DataBase Reference | 6609-57-0(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302+H312+H332-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280-P301+P312-P302+P352+P312-P304+P340+P312-P305+P351+P338 | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 20/21/22-36/37/38 | |||||||||
| Safety Statements | 26-37/39 | |||||||||
| RIDADR | UN3276 | |||||||||
| WGK Germany | 2 | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29269095 | |||||||||
| NFPA 704 |
|
2-Ethoxybenzonitrile price More Price(22)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 283576 | 2-Ethoxybenzonitrile 98% | 6609-57-0 | 1g | $93.6 | 2023-01-07 | Buy |
| TCI Chemical | E0968 | 2-Ethoxybenzonitrile >98.0%(GC) | 6609-57-0 | 5g | $35 | 2025-07-31 | Buy |
| TCI Chemical | E0968 | 2-Ethoxybenzonitrile >98.0%(GC) | 6609-57-0 | 25g | $107 | 2025-07-31 | Buy |
| TRC | E891333 | 2-Ethoxybenzonitrile | 6609-57-0 | 250mg | $45 | 2021-12-16 | Buy |
| Matrix Scientific | 003296 | 2-Ethoxybenzonitrile 98% | 6609-57-0 | 25g | $53 | 2021-12-16 | Buy |
2-Ethoxybenzonitrile Chemical Properties,Uses,Production
Uses
2-Ethoxybenzonitrile has been used in the synthesis of selective phosphodiesterase(V) inhibitor, vardenafil.
Synthesis
64-67-5
611-20-1
6609-57-0
To a 250 mL three-necked flask was added 5.95 g (0.05 mol) of o-hydroxybenzonitrile, 20 mL of 10% aqueous NaOH and 80 mL of toluene and the mixture was heated to 70 °C and maintained at this temperature for 1 hour of reaction. Subsequently, the temperature was lowered to 60 °C and 9.24 g of diethyl sulfate was slowly added dropwise. After the dropwise addition, the reaction temperature was raised to 70 °C and the reaction was continued for 2 hours. The progress of the reaction was monitored by thin layer chromatography (TLC) until o-hydroxybenzonitrile completely disappeared. After completion of the reaction, the mixture was cooled to room temperature and liquid-liquid separation was carried out. The toluene layer was collected and the solvent was removed by evaporation to give a light yellow oily liquid 2-ethoxybenzonitrile 6.98 g in 95% yield.
References
[1] Patent: CN108440519, 2018, A. Location in patent: Paragraph 0021; 0022; 0023; 0024
[2] Patent: CN108341808, 2018, A. Location in patent: Paragraph 0021; 0022; 0023
2-Ethoxybenzonitrile Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29734 | 60 |
| Changzhou Ansciep Chemical Co., Ltd. | +86 519 86305871 | sales@ansciepchem.com | CHINA | 4241 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29799 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | contact@fuxinpharm.com | China | 10035 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| Win-Win chemical CO., Limited | +86-0086-577-64498589 +86-15355981851 | sales@win-winchemical.com | China | 14360 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52846 | 58 |
| CR Corporation Limited | +8613062833949 | fred.wen@crcorporation.cn | China | 8647 | 58 |
| sgtlifesciences pvt ltd | +8617013299288 | dj@sgtlifesciences.com | China | 12373 | 58 |
| GLR Innovations | +91 9891111994 | info@glrgroup.in | India | 4535 | 58 |
View Lastest Price from 2-Ethoxybenzonitrile manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-08 | 2-Ethoxybenzonitrile
6609-57-0
|
US $1.00 / KG | 1KG | 98%HPLC | 10 tons/month | Career Henan Chemical Co |
-
- 2-Ethoxybenzonitrile
6609-57-0
- US $1.00 / KG
- 98%HPLC
- Career Henan Chemical Co
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