4-(Trifluoromethoxy)fluorobenzene
- CAS No.
- 352-67-0
- Chemical Name:
- 4-(Trifluoromethoxy)fluorobenzene
- Synonyms
- 1-FLUORO-4-(TRIFLUOROMETHOXY)BENZENE;uoro-4-(trifL;P-FLUORO(TRIFLUOROMETHOXY)BENZENE;4-(TRIFLUOROMETHOXY)FLUOROBENZENE;4-FLUORO(TRIFLUOROMETHOXY)BENZENE;p-(Trifluoromethoxy)fluorobenzene;4- hydroxyl -3-Methyl acetophenone;4-(TRIFLUOROMETHOXY)-1-FLUORBENZENE;4-(Trifluoromethoxy)phenyl fluoride;4-Fluorophenyl trifluoromethyl ether
- CBNumber:
- CB6209447
- Molecular Formula:
- C7H4F4O
- Molecular Weight:
- 180.1
- MDL Number:
- MFCD00040835
- MOL File:
- 352-67-0.mol
| Boiling point | 104-105 °C(lit.) |
|---|---|
| Density | 1.323 g/mL at 25 °C(lit.) |
| refractive index |
n |
| Flash point | 60 °F |
| storage temp. | Store below +30°C. |
| form | liquid |
| Specific Gravity | 1.323 |
| color | Clear, colourless |
| Water Solubility | Not miscible or difficult to mix in water. |
| BRN | 2046330 |
| InChI | InChI=1S/C7H4F4O/c8-5-1-3-6(4-2-5)12-7(9,10)11/h1-4H |
| InChIKey | JULMJGDXANEQDP-UHFFFAOYSA-N |
| SMILES | C1(F)=CC=C(OC(F)(F)F)C=C1 |
| CAS DataBase Reference | 352-67-0(CAS DataBase Reference) |
| FDA UNII | GY6RDC3FBT |
| NIST Chemistry Reference | P-fluorophenyl trifluoromethyl ether(352-67-0) |
| UNSPSC Code | 12352112 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS02 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H225 | |||||||||
| Precautionary statements | P210-P233-P240-P241-P242-P243 | |||||||||
| Hazard Codes | F,Xi | |||||||||
| Risk Statements | 11-36/37/38 | |||||||||
| Safety Statements | 16-26-36/37/39 | |||||||||
| RIDADR | UN 1993 3/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Irritant | |||||||||
| HazardClass | 3 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29093090 | |||||||||
| Limited Quantities | 1.0 L (0.3 gallon) (liquid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml) | |||||||||
| NFPA 704 |
|
4-(Trifluoromethoxy)fluorobenzene price More Price(27)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 8.41175 | 4-(Trifluoromethoxy)-1-fluorobenzene for synthesis | 352-67-0 | 1mL | $108 | 2025-07-31 | Buy |
| TRC | F598938 | 1-Fluoro-4-(trifluoromethoxy)benzene | 352-67-0 | 2.5g | $65 | 2021-12-16 | Buy |
| Apolloscientific | PC4370D | 1-Fluoro-4-(trifluoromethoxy)benzene | 352-67-0 | 100g | $67 | 2021-12-16 | Buy |
| SynQuest Laboratories | 2607-3-41 | 1-Fluoro-4-(trifluoromethoxy)benzene 99% | 352-67-0 | 100g | $74 | 2021-12-16 | Buy |
| Matrix Scientific | 008766 | 4-(Trifluoromethoxy)fluorobenzene 98% | 352-67-0 | 100g | $63 | 2021-12-16 | Buy |
4-(Trifluoromethoxy)fluorobenzene Chemical Properties,Uses,Production
Uses
It is employed as an active pharmaceutical intermediate.
Synthesis
338792-64-6
352-67-0
The general procedure for the synthesis of p-fluorotrifluoromethoxybenzene from 2,2-difluoro-2-(4-fluorophenoxy)acetic acid was as follows: a stir bar was added to a 5 mL microwave vial in an argon-protected glove box and sealed. Selectfluor (177.1 mg, 0.5 mmol, 2.0 eq.), silver trifluoromethanesulfonate (12.8 mg, 0.05 mmol, 20 mol%), and 2,2-difluoro-2-(4-fluorophenoxy)acetic acid (0.25 mmol, 1.0 eq.) were added sequentially. The vial was charged with dichloromethane (1.8 mL), trifluoroacetic acid (76.5 μL, 1.0 mmol, 4.0 equiv) and water (0.2 mL). The reaction mixture was heated at 55 °C for 1 hour. After completion of the reaction, the mixture was cooled to room temperature, diluted with dichloromethane (4 mL), washed sequentially with water (3 x 5 mL) and brine (5 mL), dried over anhydrous magnesium sulfate and filtered. The dried organic phase was concentrated on a rotary evaporator. The crude product obtained was dissolved in a small amount of dichloromethane and purified by passing through a silica gel column (10 g, Biotage), first dried with air and then eluted with pentane. The fractions containing the pure product were combined and the solvent evaporated to give pure p-fluorotrifluoromethoxybenzene.
References
[1] Organic Letters, 2016, vol. 18, # 15, p. 3754 - 3757
[2] Organic Letters, 2016, vol. 18, # 18, p. 4570 - 4573
[3] Angewandte Chemie - International Edition, 2016, vol. 55, # 33, p. 9758 - 9762
[4] Angew. Chem., 2016, vol. 128, # 33, p. 9910 - 9914,5
[5] Journal of Fluorine Chemistry, 2017, vol. 203, p. 130 - 135
4-(Trifluoromethoxy)fluorobenzene Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Coresyn Pharmatech Co., Ltd. | +86-571-86626709 +86-18157142896 | cbc@coresyn.com | China | 9984 | 58 |
| Capot Chemical Co.,Ltd. | +8613336195806 | sales@capot.com | China | 29734 | 60 |
| Fluoropharm Co., Ltd. | +86-0571-85586753 +86-13336034509 | sales@fluoropharm.com | China | 1445 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29852 | 58 |
| NINGBO INNO PHARMCHEM CO., LTD. | 13867897135 | sales@nbinno.com | CHINA | 923 | 58 |
| Win-Win Chemical CO., Limited | 0086-577-64498589 | sales@win-winchemical.com | CHINA | 998 | 58 |
| SHANDONG ZHI SHANG CHEMICAL CO.LTD | +86 18953170293 | sales@sdzschem.com | China | 2930 | 58 |
| Shanghai Worldyang Chemical Co.,Ltd. | +86-021-56795779 +8613651600618 | sales@worldyachem.com | China | 1382 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
View Lastest Price from 4-(Trifluoromethoxy)fluorobenzene manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-01-03 | 4-(Trifluoromethoxy)fluorobenzene
352-67-0
|
US $0.00-0.00 / KG | 10mg | 99% | 2000tons | Shaanxi Dideu Medichem Co. Ltd | |
 |
2019-07-06 | 4-(Trifluoromethoxy)fluorobenzene
352-67-0
|
US $1.00 / KG | 1KG | 99% | Customized | Career Henan Chemical Co |
-
- 4-(Trifluoromethoxy)fluorobenzene
352-67-0
- US $0.00-0.00 / KG
- 99%
- Shaanxi Dideu Medichem Co. Ltd
-
- 4-(Trifluoromethoxy)fluorobenzene
352-67-0
- US $1.00 / KG
- 99%
- Career Henan Chemical Co
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