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5-Chlorouracil

5-Chlorouracil Structure
5-Chlorouracil structure
CAS No.
1820-81-1
Chemical Name:
5-Chlorouracil
Synonyms
5-CHLOROPYRIMIDINE-2,4(1H,3H)-DIONE;Fluorouracil EP Impurity E;5-Chloropyrimidine-2,4-diol;5-Chloro-1H-pyrimidine-2,4-dione;NSC 28172;5-chloro-uraci;5-CHLOROURACIL;Uracil,5-chloro-;5-CHLORO-5-URACIL;5-Chlorouracil,99%
CBNumber:
CB6216858
Molecular Formula:
C4H3ClN2O2
Molecular Weight:
146.53
MDL Number:
MFCD00006019
MOL File:
1820-81-1.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-06-04 16:00:12
Product description Number Pack Size Price
5-Chlorouracil 99% 224588 5g $101
Fluorouracil Related Compound E certified reference material, pharmaceutical secondary standard PHR2867 50MG $707
Fluorouracil Related Compound E United States Pharmacopeia (USP) Reference Standard 1279054 25mg $1290
5-Chlorouracil >98.0%(T) C0969 5g $56
5-Chlorouracil >98.0%(T) C0969 25g $162
More product size
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5-Chlorouracil Properties

Melting point >300 °C (lit.)
Density 1.6838 (rough estimate)
refractive index 1.6550 (estimate)
storage temp. 2-8°C
solubility 1 M NH4OH: soluble50mg/mL
pka 6.77±0.10(Predicted)
form Solid
color White to Off-White
Water Solubility 2.501g/L(25 ºC)
BRN 127173
InChI InChI=1S/C4H3ClN2O2/c5-2-1-6-4(9)7-3(2)8/h1H,(H2,6,7,8,9)
InChIKey ZFTBZKVVGZNMJR-UHFFFAOYSA-N
SMILES C1(=O)NC=C(Cl)C(=O)N1
CAS DataBase Reference 1820-81-1(CAS DataBase Reference)
FDA UNII 7LQ4V03RNY
EPA Substance Registry System 5-Chlorouracil (1820-81-1)
UNSPSC Code 41116107
NACRES NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)  Skull and Crossbones (GHS06)Health Hazard (GHS08)
GHS06,GHS08
Signal word  Danger
Hazard statements  H301-H341
Precautionary statements  P201-P202-P264-P270-P280-P301+P310
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  22-24/25-36-26
RIDADR  UN2811
WGK Germany  3
RTECS  YQ9410000
HazardClass  6.1
HS Code  29335995
Storage Class 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects
Hazard Classifications Acute Tox. 3 Oral
Muta. 2
REACH Registrations Active
Limited Quantities 5.0 kg (11 lbs) (solid)
Excepted Quantities Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)
NFPA 704
1
0 0

5-Chlorouracil price More Price(86)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 224588 5-Chlorouracil 99% 1820-81-1 5g $101 2026-04-30 Buy
Sigma-Aldrich PHR2867 Fluorouracil Related Compound E certified reference material, pharmaceutical secondary standard 1820-81-1 50MG $707 2026-04-30 Buy
Sigma-Aldrich 1279054 Fluorouracil Related Compound E United States Pharmacopeia (USP) Reference Standard 1820-81-1 25mg $1290 2026-04-30 Buy
TCI Chemical C0969 5-Chlorouracil >98.0%(T) 1820-81-1 5g $56 2026-04-30 Buy
TCI Chemical C0969 5-Chlorouracil >98.0%(T) 1820-81-1 25g $162 2026-04-30 Buy
Product number Packaging Price Buy
224588 5g $101 Buy
PHR2867 50MG $707 Buy
1279054 25mg $1290 Buy
C0969 5g $56 Buy
C0969 25g $162 Buy

5-Chlorouracil Chemical Properties,Uses,Production

Description

5-Chlorouracil (5-CU) may have advantages for the inhibition of undesired fibroblast proliferation taking place after surgery for glaucoma and results in filtration failure. A comparison of 5-CU and 5-fluorouracil (5-FU) cytotoxicity shows that 5-CU is approximately 1000 times less toxic to nonproliferative cells while maintaining good antimitotic activity. In addition, 5-CU induces apoptotic-controlled cell death, whereas the influence of 5-FU is by apoptonecrosis. The 5-CU apoptotic mechanism is driven mainly by the nuclear translocation of AIF and activation of the LEI/L-DNase II pathways, which are caspase-independent. In conclusion, even though 5-CU is a weaker antiproliferating agent than 5-FU, its reduced toxic side effects on the epithelium and sclera allow for its enhanced efficacy and extended reduction of IOP after filtering surgery for glaucoma. 5-CU is an effective mutagen, clastogen and toxicant, and an effective inducer of sister-chromatid exchange, and is not as sensitive to ionizing radiation as other thymine analogues[1].

Chemical Properties

white to light beige crystalline powder

Uses

5-Chlorouracil was used as a control in resazurin-based cytotoxicity assay for screening of cytotoxicity in hepatocytes and liver cell lines.

Uses

5-Chlorouracil can be used for the experimental and clinical treatment of neoplastic and viral diseases.

Definition

ChEBI: An organochlorine compound consisting of uracil having an chloro substituent at the 5-position. It is functionally related to a uracil.

General Description

The shape resonance spectra of 5-chlorouracil, obtained from fixed-nuclei elastic scattering calculations by the Schwinger multichannel method with pseudopotentials, was studied.

Purification Methods

It recrystallises from hot H2O (4g/500mL) using charcoal. [McOmie et al. J Chem Soc 3478 1955, West & Barrett J Am Chem Soc 76 3146 1954, Beilstein 24 III/IV 1231.]

References

[1] Marianne Berdugo Polak. “Controlled delivery of 5-chlorouracil using poly(ortho esters) in filtering surgery for glaucoma.” Investigative ophthalmology & visual science (2008): 2993–3003.

5-Chlorouracil Preparation Products And Raw materials

Raw materials

Preparation Products

2,4,5-Trichloropyrimidine

5-Chlorouracil Suppliers

Global( 466)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Chuanghai Biotechnology Co., Ltd 		+8615350571055 Sibel@chuanghaibio.com China 8738 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29640 60
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21587 55
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29815 58
Zhejiang ZETian Fine Chemicals Co. LTD 		+8618957127338 stella@zetchem.com China 2994 58
Accela ChemBio Inc. 		+1-858-6993322 info@accelachem.com United States 21193 58
Xiamen AmoyChem Co., Ltd 		+86-86-5926051114 +8615060885618 sales@amoychem.com China 6366 58
Xi'an Kono chem co., Ltd., 		029-86107037 13289246953 info@konochemical.com China 1169 58
Standardpharm Co. Ltd. 		86-714-3992388 overseasales1@yongstandards.com United States 14332 58
Supplier Advantage
Hebei Chuanghai Biotechnology Co., Ltd 		58
Capot Chemical Co.,Ltd. 		60
Henan Tianfu Chemical Co.,Ltd. 		55
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
Zhejiang ZETian Fine Chemicals Co. LTD 		58
Accela ChemBio Inc. 		58
Xiamen AmoyChem Co., Ltd 		58
Xi'an Kono chem co., Ltd., 		58
Standardpharm Co. Ltd. 		58

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View Lastest Price from 5-Chlorouracil manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
5-Chlorouracil pictures 2026-04-21 5-Chlorouracil
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 $772.00 10g TargetMol Chemicals Inc.
5-Chlorouracil pictures 2026-03-20 5-Chlorouracil
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 $10.00 1KG 99% 10 mt Hebei Chuanghai Biotechnology Co., Ltd
5-chloro-2,4-dioxopyrimidine pictures 2021-07-09 5-chloro-2,4-dioxopyrimidine
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 $2.00 1KG 99.7% Hebei Xibaijie Biotechnology Co., Ltd.
  • 5-Chlorouracil pictures
  • 5-Chlorouracil
    1820-81-1
  • $10.00
  • 99%
  • Hebei Chuanghai Biotechnology Co., Ltd

5-Chlorouracil Spectrum

5-Chlorouracil(1820-81-1)MS5-Chlorouracil(1820-81-1)1HNMR5-Chlorouracil(1820-81-1)IR15-Chlorouracil(1820-81-1)IR25-Chlorouracil(1820-81-1)Raman

1820-81-1(5-Chlorouracil)Related Search:

Uracil Difluorochloromethane 5-Chlorouridine Terbacil 5-CHLORO-6-METHYLURACIL
4-AMINOPYRAZOLO[3,4-D]PYRIMIDINE 6-Chlorouracil 6-methyl-5-chlorouracil 1,3-Dimethyl-4-chlorouracil,1,3-DIMETHYL-6-CHLOROURACIL 6-Chloro-3-methyluracil
2,4(1H,3H)-Pyrimidinedione,5-chloro-6-(chloromethyl)-(9CI) 5-CHLORO-2'-DEOXYURIDINE 1-(3-Fluoro-2,3-dideoxy-β-D-erythro-pentofuranosyl)-5-chlorouracil 5-Chloro-2',3'-O-isopropylidene-D-uridine 5-Chloro-5'-deoxy-5'-iodo-2',3'-O-isopropylidene-D-uridine
5-Chlorouracil-15N2,13C 1,3,5-TRICHLOROURACIL 5-CHLORO-5'-DEOXYURIDINE

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TIMTEC-BB SBB004103 2,4(1H,3H)-Pyrimidinedione,5-chloro- 2,4-Pyrimidinediol,5-chloro- 3h)-pyrimidinedione,5-chloro-4(1h 5-Chloro-1,2,3,4-tetrahydropyrimidine-2,4-dione 5-Chlorouracil,99% Fluorouracil Related CoMpound E 5-Chlorouracil ReagentPlus(R), 99% Fluorouracil Related Compound E (25 mg) (5-Chloropyrimidine-2,4(1H,3H)-dione) 5-Chlorouracil Vetec(TM) reagent grade, 98% Fluorouracil Impurity 5（Fluorouracil EP Impurity E） Fluorouracil EP Impurity E 5-Chlor-2,4-dihydroxypyrimidin 5-Chloro-1H-pyrimidine-2,4-dione 5-Chloro-2,4-pyrimidinedione 5-chloro-uraci Uracil,5-chloro- 5-CHLORO-2,4-DIHYDROXYPYRIMIDINE 5-CHLORO-5-URACIL 5-CHLOROURACIL 5-CHLOROURACIL,5-CHLORO-2,4-DIHYDROXYPYRIMIDINE 2,4(1H,3H)-Pyrimidinedione, 5-chloro- (9CI) 5-Chloro-2,4(1H,3H)-pyrimidinedione NSC 28172 5-CHLOROURACIL CRYSTALLINE 5-Chlorouracil,98% Fluorouracil BP Impurity E 5-Chlorouracil > 5-Chlorouracil USP/EP/BP 5-Chlorouracil (Fluorouracil Impurity) 4(1H,3H)-Pyrimidinedione,5-chloro- Fluorouracil EP Impurity E (5-Chlorouracil) 5-ChlorouracilQ: What is 5-Chlorouracil Q: What is the CAS Number of 5-Chlorouracil Q: What is the storage condition of 5-Chlorouracil Q: What are the applications of 5-Chlorouracil Fluorouracil Related Compound E (5-Chloropyrimidine-2,4(1H,3H)-dione) (1279054) Fluorouracil USP Related Compound E 5-chloro-2,4-dioxopyrimidine Fluorouracil Related Compound E (5-Chloropyrimidine-2,4(1H,3H)-dione) Fluorouracil EP Impurity E (Fluorouracil USP Related Compound E) 5-Chloropyrimidine-2,4(1H,3H)-dione (5-Chlorouracil) 5-Chloropyrimidine-2,4-diol 5-CHLOROPYRIMIDINE-2,4(1H,3H)-DIONE 1820-81-1 156-2-19 C4H3ClN2O2 Building Blocks Pyrimidines Heterocyclic Building Blocks Halogenated Heterocycles Pyrimidine series Heterocyclic Compounds Biochemistry Nucleobases and their analogs Nucleosides, Nucleotides & Related Reagents Nucleic acids Bases & Related Reagents Heterocycles Nucleotides PYRIMIDINE