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(+)-FANGCHINOLINE

(+)-FANGCHINOLINE structure

CAS No.: 436-77-1

Chemical Name:: (+)-FANGCHINOLINE

Synonyms: Hanfangchin B（Fangchinoline）;(+)-limacine;Tetrandrine B;FANGCHINO-LINE;Hanfangichin B;Fangchinoline-RM;(+)-FANGCHINOLINE;FANGCHINOLINE (RG);7-o-demethyltetrandrine;12-O-MethylatherosperMoline

CBNumber:: CB6221346

Molecular Formula:: C37H40N2O6

Molecular Weight:: 608.72

MDL Number:: MFCD03427706

MOL File:: 436-77-1.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-04-22 18:57:36

Product description	Number	Pack Size	Price
Fangchinoline ≥98% (HPLC)	SMB00502	5 mg	$348.52
Fangchinoline	F1173	20MG	$57
Fangchinoline	F1173	100MG	$173
Fangchinoline ≥98%	29243	5mg	$66
Fangchinoline ≥98%	29243	10mg	$108
More product size

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(+)-FANGCHINOLINE Properties

Melting point	240～242℃
Boiling point	709.7±60.0 °C(Predicted)
Density	1.204±0.06 g/cm3(Predicted)
storage temp.	4°C, protect from light
solubility	Soluble in chloroform and methanol;
pka	9.38±0.20(Predicted)
form	powder to crystal
color	White to Orange to Green
Water Solubility	slightly soluble in water
Major Application	metabolomics vitamins, nutraceuticals, and natural products
InChIKey	IIQSJHUEZBTSAT-VMPREFPWSA-N
SMILES	OC1C(=CC2CCN([C@@]3([H])CC4=CC=C(C(OC5=CC=C(C=C5)C[C@]5([H])N(CCC6=CC(=C(C=C65)OC=1C3=2)OC)C)=C4)OC)C)OC
FDA UNII	953592C3ZB
UNSPSC Code	12352205
NACRES	NA.25

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302

Precautionary statements

P264-P270-P301+P312-P330-P501

WGK Germany

WGK 3

HS Code

2939.79.0000

Storage Class

11 - Combustible Solids

Hazard Classifications

Acute Tox. 4 Oral

NFPA 704

	0
2		0

(+)-FANGCHINOLINE price More Price(24)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	SMB00502	Fangchinoline ≥98% (HPLC)	436-77-1	5 mg	$348.52	2025-07-31	Buy
TCI Chemical	F1173	Fangchinoline	436-77-1	20MG	$57	2026-04-30	Buy
TCI Chemical	F1173	Fangchinoline	436-77-1	100MG	$173	2026-04-30	Buy
Cayman Chemical	29243	Fangchinoline ≥98%	436-77-1	5mg	$66	2026-04-30	Buy
Cayman Chemical	29243	Fangchinoline ≥98%	436-77-1	10mg	$108	2026-04-30	Buy

Product number	Packaging	Price	Buy
SMB00502	5 mg	$348.52	Buy
F1173	20MG	$57	Buy
F1173	100MG	$173	Buy
29243	5mg	$66	Buy
29243	10mg	$108	Buy

(+)-FANGCHINOLINE Chemical Properties,Uses,Production

Description

A bisbenzylisoquino!ine alkaloid obtained from Limacia cuspidata (Miers.) Hook. f. et Thorn., the base crystallizes from Me2CO in the form of long, colourless needles. It is strongly laevorotatory with [α]_D - 2120 (CHCI3) and has been shown to be the optical antipode of fanchinoline (q.v.).

Description

Fangchinoline is an alkaloid that has been found in S. tetrandrae and has diverse biological activities, including anti-inflammatory, neuroprotective, and anticancer properties. It inhibits the activity of sheep COX and decreases IL-6-induced proliferation of MH60 mouse hybridoma cells with IC₅₀ values of 129 and 3.7 μM, respectively. Fangchinoline (1 and 10 μM) reduces cyanide-induced increases in secreted glutamate levels and cell death in primary neonatal rat cerebellar granule neurons. It decreases proliferation of PC3 human prostate cancer cells by 63 and 86% when used at concentrations of 20 and 30 μM, respectively. Fangchinoline reduces tumor growth in a PC3 mouse xenograft model when administered at a dose of 5 mg/kg per day for 12 days.

Chemical Properties

Sourced from the scorched roots of Stephania tetrandra S. Moore, family Stephanaceae.

Uses

(+)-Fangchinoline is an isolate from Stephania Tetrandra that shows anti-cancer activity. It inhibits breast adenocarcinoma proliferation through apoptosis induction. In addition, it has been shown to inhibit HIV-Type 1 replication.

Definition

ChEBI: A bisbenzylisoquinoline alkaloid that is (1beta)- berbaman which has been substituted by methyl groups at the 2 and 2' positions, by methoxy groups at the 6, 6', and 12 positions, and by a hydroxy group at position 7. Isolated from S ephania tetrandra, it has been found to possess neuroprotective and anti-tumour activity.

IC 50

HIV-1

References

Tomita, Furukawa., Tetrahedron Lett., 4293 (1966)

(+)-FANGCHINOLINE Preparation Products And Raw materials

Raw materials

Preparation Products

(+)-FANGCHINOLINE Suppliers

Global( 258)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	+8615531151365	mina@chuanghaibio.com	China	18126	58
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29819	58
Chengdu GLP biotechnology Co Ltd	028-87075086 13350802083	scglp@glp-china.com	CHINA	1824	58
Chengdu Biopurify Phytochemicals Ltd.	+86-28-82633860; +8618080483897	sales@biopurify.com	China	3751	58
Nanjing Dolon Biotechnology Co.,Ltd.	18905173768	52513593@qq.com	CHINA	2972	58
Xiamen AmoyChem Co., Ltd	+86-86-5926051114 +8615060885618	sales@amoychem.com	China	6369	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19552	58
Shanghai Standard Technology Co., Ltd.	18502101150	ft-sales@nature-standard.com	CHINA	1923	58
SIMAGCHEM CORP	+86-5922680277 +86-13806087780	sale@simagchem.com	China	17346	58
Wuhan ChemNorm Biotech Co.,Ltd.	+86-27-8439 4403 18971486879	sales@chemnorm.com	CHINA	2935	58

Supplier	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	58
career henan chemical co	58
Chengdu GLP biotechnology Co Ltd	58
Chengdu Biopurify Phytochemicals Ltd.	58
Nanjing Dolon Biotechnology Co.,Ltd.	58
Xiamen AmoyChem Co., Ltd	58
BOC Sciences	58
Shanghai Standard Technology Co., Ltd.	58
SIMAGCHEM CORP	58
Wuhan ChemNorm Biotech Co.,Ltd.	58

View Lastest Price from (+)-FANGCHINOLINE manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-04-22	Fangchinoline 436-77-1	US $40.00-97.00 / mg		99.98%	10g	TargetMol Chemicals Inc.
2025-06-27	(+)-FANGCHINOLINE 436-77-1	US $30.00-10.00 / KG	50KG	99%	500000kg	Hebei Chuanghai Biotechnology Co., Ltd
2023-02-24	Fangchinoline 436-77-1	US $0.00 / mg	5mg	≥98%(HPLC)	10 g	Shanghai Standard Technology Co., Ltd.

Fangchinoline
436-77-1
US $40.00-97.00 / mg
99.98%
TargetMol Chemicals Inc.

(+)-FANGCHINOLINE
436-77-1
US $30.00-10.00 / KG
99%
Hebei Chuanghai Biotechnology Co., Ltd

Fangchinoline
436-77-1
US $0.00 / mg
≥98%(HPLC)
Shanghai Standard Technology Co., Ltd.

(+)-FANGCHINOLINE Spectrum

(+)-FANGCHINOLINE(436-77-1)¹HNMR

436-77-1((+)-FANGCHINOLINE)Related Search:

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Polysaccharide Protocatechualdehyde FORSYTHIN Glabridin Magnolia officinalis P.E.

7-O-isopropyl fangchinoline FANGCHINOLINE >90% BY HPLC 7-O-ethyl fangchinoline

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FANGCHINOLINE (RG) Hanfangchin B（Fangchinoline） FANGCHINOLINE; HANFANGCHIN B 12-O-MethylatherosperMoline Tetrandrine B Fangchinoline, 98%, from Stephania tetrandra S. Moore (+)-limacine (1-beta)-2,2’-dimethyl-6,6’,12-trimethoxyberbaman-7-ol 2’-dimethyl-6,6’,12-trimethoxy-(1-beta)-berbaman-7-o 7-o-demethyltetrandrine 6,6',12-TRIMETHOXY-2,2'-DIMETHYLBERBAMAN-7-OL (+)-FANGCHINOLINE FANGCHINO-LINE Fangchinoline, Demethyltetrandrine Hanfangichin B Berbaman-7-ol,6,6',12-trimethoxy-2,2'-dimethyl-, (1β)- (1S)-6,6',12-Trimethoxy-2,2'-dimethylberbaman-7-ol (1S)-7-Hydroxy-6,6',12-trimethoxy-2,2'-dimethylberbaman 16H-1,24:6,9-Dietheno-11,15-metheno-2H-pyrido[2',3':17,18][1,11]dioxacycloeicosino[2,3,4-ij]isoquinolin-22-ol, 3,4,4a,5,16a,17,18,19-octahydro-12,21,26-trimethoxy-4,17-dimethyl-, (4aS,16aS)- (+)-FANGCHINOLINE USP/EP/BP (11S,31S)-16,36,54-Trimethoxy-12,32-dimethyl-11,12,13,14,31,32,33,34-octahydro-2,6-dioxa-1(7,1),3(8,1)-diisoquinolina-5(1,3),7(1,4)-dibenzenacyclooctaphan-37-ol 16H-1,24:6,9-Dietheno-11,15-metheno-2H-pyrido[2',3':17,18][1,11]dioxacycloeicosino[2,3,4-ij]isoquinolin-22-ol,3,4,4a,5,16a,17,18,19-octahydro-12,21,26-trimethoxy-4,17-dimethyl-,(4aS,16aS)- Fangchinoline-RM Fangchinoline, 10 mM in DMSO 436-77-1 C37H48N2O6 reference substance Alkaloids