NODULARIN
- CAS No.
- 118399-22-7
- Chemical Name:
- NODULARIN
- Synonyms
- NODULARIN;Nodularin-R solution;Nodularin in methanol;Nodularin solution ;Nodularin, 5μg in 0.5 mL;IXBQSRWSVIBXNC-HSKGSTCASA-N;Nodularin, Nodularia spumigena;yl-10-phenyl-3-aminodecanoyl-d-gamma-glutamyl);1,4,8,11,15-Pentaazacyclononadecane, cyclic peptide;Nodularin,1,4,8,11,15-Pentaazacyclononadecane, cyclic peptide
- CBNumber:
- CB6225379
- Molecular Formula:
- C41H60N8O10
- Molecular Weight:
- 824.96
- MDL Number:
- MFCD16659855
- MOL File:
- 118399-22-7.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Nodularin cyanotoxin | N5148 | 250μg | $703 |
| Nodularin solution 10μg/mL in methanol, analytical standard | 32539 | 1ml | $654 |
| Nodularin ≥95% | 10007190 | 100μg | $152 |
| Nodularin ≥95% | 10007190 | 100μg | $138 |
| Nodularin (in ethanol) ≥95% | 170023 | 100ug | $325 |
| Density | 1.29±0.1 g/cm3(Predicted) |
|---|---|
| Flash point | 11℃ |
| storage temp. | −20°C |
| solubility | methanol: 2 mg/mL Further dilute to 10% (v/v) methanol. Store solutions at −20°C for up to six months. |
| form | Dry residue containing traces of monobasic potassium phosphate. |
| pka | 3.39±0.70(Predicted) |
| Sequence | cyclo({Abu}-{Bas}-Arg-{Oaa}-{Ggu}) |
| Major Application |
cleaning products cosmetics food and beverages personal care |
| InChIKey | IXBQSRWSVIBXNC-HSKGSTCASA-N |
| SMILES | CO[C@@H](Cc1ccccc1)[C@@H](C)\C=C(C)\C=C\[C@@H]2NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](C)[C@@H](NC(=O)\C(=C\C)N(C)C(=O)CC[C@@H](NC(=O)[C@H]2C)C(O)=O)C(O)=O |
| FDA UNII | 0979BIK2QU |
| IARC | 3 (Vol. 94) 2010 |
| EPA Substance Registry System | Nodularin (118399-22-7) |
| UNSPSC Code | 85151701 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H300+H310+H330-H315-H317-H319-H335 | |||||||||
| Precautionary statements | P260-P262-P280-P302+P352+P310-P304+P340+P310-P305+P351+P338 | |||||||||
| target organs | Eyes | |||||||||
| PPE | Eyeshields, Faceshields, Gloves | |||||||||
| Hazard Codes | T,F,T+ | |||||||||
| Risk Statements | 23/24/25-38-39/23/24/25-11-43-36/37/38-26/27/28 | |||||||||
| Safety Statements | 36/37-45-16-7-36/37/39-26 | |||||||||
| RIDADR | UN 2811 6.1/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | GU2294250 | |||||||||
| Storage Class | 3 - Flammable liquids | |||||||||
| Hazard Classifications | Acute Tox. 3 Dermal Acute Tox. 3 Inhalation Acute Tox. 3 Oral Flam. Liq. 2 STOT SE 1 |
|||||||||
| Hazardous Substances Data | 118399-22-7(Hazardous Substances Data) | |||||||||
| Toxicity | mouse,LD50,intraperitoneal,60ug/kg (0.06mg/kg),Chemical Research in Toxicology. Vol. 6, Pg. 151, 1993. | |||||||||
| NFPA 704 |
|
NODULARIN price More Price(15)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | N5148 | Nodularin cyanotoxin | 118399-22-7 | 250μg | $703 | 2026-04-30 | Buy |
| Sigma-Aldrich | 32539 | Nodularin solution 10μg/mL in methanol, analytical standard | 118399-22-7 | 1ml | $654 | 2026-04-30 | Buy |
| Cayman Chemical | 10007190 | Nodularin ≥95% | 118399-22-7 | 100μg | $152 | 2026-04-30 | Buy |
| Cayman Chemical | 10007190 | Nodularin ≥95% | 118399-22-7 | 100μg | $138 | 2024-03-01 | Buy |
| Usbiological | 170023 | Nodularin (in ethanol) ≥95% | 118399-22-7 | 100ug | $325 | 2026-06-03 | Buy |
NODULARIN Chemical Properties,Uses,Production
Description
The cyanobacterium Nodularia spumigena often contaminates the drinking water of rural communities in developing countries and accumulates in mussels, flounder, and cod from the northern Baltic Sea. Nodularin is a hepatotoxic monocylic pentapeptide produced by the N. spumigena. It is a potent inhibitor of protein phosphatase types 1 (PP1) and 2A (PP2A), exhibiting IC50 values of 1.8 and 0.026 nM, respectively. PP2B is inhibited to a lesser extent with an IC50 of 1.8 μM. No apparent inhibitory effect is observed with PP2C, alkaline phosphatase, acid phosphatase, insulin receptor tyrosine kinase, protein kinase A, phosphorylase kinase, or protein kinase C.
Uses
Nodularin-R is a cyclic peptide toxin produced by freshwater cyanobacteria.
Definition
Toxin produced by blue green algae.
References
[1] YAFEI DUAN. Toxicological response of Pacific white shrimp Litopenaeus vannamei to a hazardous cyanotoxin nodularin exposure.[J]. Environmental Pollution, 2023, 318: 120950. DOI: 10.1016/j.envpol.2022.120950
[2] R E HONKANEN. Cyanobacterial nodularin is a potent inhibitor of type 1 and type 2A protein phosphatases.[J]. Molecular Pharmacology, 1991, 40 4: 577-583.
[3] T. PARK. Marked inhibition of testosterone biosynthesis by the hepatotoxin nodularin due to apoptosis of Leydig cells[J]. Molecular Carcinogenesis, 2002, 34 1. DOI: 10.1002/mc.10059
[4] DOUGLAS. O. MOUNTFORT Jan S Patrick Holland. Method for detecting classes of microcystins by combination of protein phosphatase inhibition assay and ELISA: comparison with LC-MS[J]. Toxicon, 2005, 45 2: Pages 199-206. DOI: 10.1016/j.toxicon.2004.10.008
[5] V. SIPI. Detection of nodularin in flounders and cod from the Baltic Sea[J]. Environmental Toxicology, 2001, 23 1. DOI: 10.1002/tox.1015
NODULARIN Preparation Products And Raw materials
Raw materials
Preparation Products
NODULARIN Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19936 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32466 | 58 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9804 | 58 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6777 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11218 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8140 | 58 |
| cjbscvictory | 13348960310 13348960310 | 3003867561@qq.com | China | 10336 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24955 | 58 |
| Naturewill Biotechnology Co., Ltd. | 028-82632533 18113192475 | 3157321941@qq.com | China | 4993 | 58 |
| Tanmo Quality Inspection Technology Co., Ltd. | 4008-099-669 | 23419001name@qq.com | CHINA | 6043 | 58 |
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