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4-AMINO-2-METHYLQUINOLINE

4-AMINO-2-METHYLQUINOLINE Structure
4-AMINO-2-METHYLQUINOLINE structure
CAS No.
6628-04-2
Chemical Name:
4-AMINO-2-METHYLQUINOLINE
Synonyms
4-AMINOQUINALDINE;2-METHYLQUINOLIN-4-AMINE;NSC 60281;AKOS AUF2104;4-AMinoquinald;4-Quinaldinamine;TIMTEC-BB SBB003992;5-4-Aminoquinaldine;4-Aminoquinaldine,98%;LABOTEST-BB LT02084860
CBNumber:
CB6227904
Molecular Formula:
C10H10N2
Molecular Weight:
158.2
MDL Number:
MFCD00006759
MOL File:
6628-04-2.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 03:31:01
Product description Number Pack Size Price
4-Aminoquinaldine 98% A79000 5g $88.1
4-Aminoquinaldine matrix substance for MALDI-MS, ≥99.0% (HPLC) 05851 1g $409
4-Amino-2-methylquinoline >97.0%(GC)(T) A0415 5g $235
4-Amino-2-methylquinoline >97.0%(GC)(T) A0415 25g $697
4-Aminoquinaldine FA34677 10g $266.3
More product size
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4-AMINO-2-METHYLQUINOLINE Properties

Melting point 162-166 °C(lit.)
Boiling point 333 °C(lit.)
Density 1.1606 (estimate)
vapor pressure 0.001Pa at 25℃
refractive index 1.7080 (estimate)
Flash point 333°C
storage temp. 2-8°C, protect from light
solubility soluble in Methanol
form powder to crystal
pka 9.40±0.50(Predicted)
color White to Orange to Green
Water Solubility Soluble in water.
BRN 118323
Stability Hygroscopic
InChI 1S/C10H10N2/c1-7-6-9(11)8-4-2-3-5-10(8)12-7/h2-6H,1H3,(H2,11,12)
InChIKey COCFIBRMFPWUDW-UHFFFAOYSA-N
SMILES Cc1cc(N)c2ccccc2n1
LogP 1.77
CAS DataBase Reference 6628-04-2(CAS DataBase Reference)
FDA UNII 5YZ7028HHH
UNSPSC Code 41116105
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
target organs Respiratory system
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-37/39
RIDADR  3259
WGK Germany  3
HazardClass  8
PackingGroup  III
HS Code  29334900
Storage Class 11 - Combustible Solids
Hazard Classifications Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
REACH Registrations Active
NFPA 704
0
2 0

4-AMINO-2-METHYLQUINOLINE price More Price(69)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich A79000 4-Aminoquinaldine 98% 6628-04-2 5g $88.1 2026-04-30 Buy
Sigma-Aldrich 05851 4-Aminoquinaldine matrix substance for MALDI-MS, ≥99.0% (HPLC) 6628-04-2 1g $409 2022-05-15 Buy
TCI Chemical A0415 4-Amino-2-methylquinoline >97.0%(GC)(T) 6628-04-2 5g $235 2026-04-30 Buy
TCI Chemical A0415 4-Amino-2-methylquinoline >97.0%(GC)(T) 6628-04-2 25g $697 2026-04-30 Buy
Biosynth FA34677 4-Aminoquinaldine 6628-04-2 10g $266.3 2026-06-04 Buy
Product number Packaging Price Buy
A79000 5g $88.1 Buy
05851 1g $409 Buy
A0415 5g $235 Buy
A0415 25g $697 Buy
FA34677 10g $266.3 Buy

4-AMINO-2-METHYLQUINOLINE Chemical Properties,Uses,Production

Chemical Properties

SLIGHTLY BEIGE TO LIGHT YELLOW POWDER

Uses

4-Amino-2-methylquinoline is used as a pharmaceutical intermediate.

Flammability and Explosibility

Non flammable

Synthesis

4-CHLORO-2-METHYLQUINOLINE

4295-06-1

4-AMINO-2-METHYLQUINOLINE

6628-04-2

General procedure for the synthesis of 4-amino-2-methylquinoline from 2-methyl-4-chloroquinoline: In an oven-dried vial (35 × 12 mm) fitted with a PTFE-sealed screw cap, a magnetic stirring bar, [(±)-BINAP]Ni[P(OPh)3]2-2PhCH3 (39 mg, 0.025 mmol, 5 mol%), (±)- BINAP (15 mg, 0.025 mmol, 5 mol%) and the corresponding aryl halide (0.50 mmol, 1.0 equiv). The vial was transferred to an argon filled glove box and NaOtBu (216 mg, 2.20 mmol, 4.40 equiv) and NH3 (0.5 M in 1,4-dioxane, 3.0 mL, 1.5 mmol, 3.0 equiv) were added sequentially. After sealing the reaction vial, it was removed from the glove box and placed in an oil bath preheated to 120°C with stirring for 18 hours. After completion of the reaction, it was cooled to room temperature and the reaction mixture was diluted with ether (15 mL) and washed sequentially with 1 M NaOH (10 mL) and water (10 mL). The organic phase was dried over anhydrous sodium sulfate, concentrated and loaded onto silica gel, and purified by fast column chromatography (ethyl acetate/hexane or ethyl acetate/methanol) to afford the target product aniline analog. 4-Amino-2-methylquinoline (19 mg, 0.23 mmol, 46%) was obtained as an orange solid from 4-chloro-2-methylquinoline (100 mg, 0.500 mmol), operated according to the above general method and purified by fast column chromatography (ethyl acetate/methanol 90:10). The spectral data of the product were in agreement with literature reports [32]. Thin layer chromatography Rf = 0.23 (ethyl acetate/methanol 90:10).1H NMR (500 MHz, CDCl3) δ: 8.06 (1H, d, J = 8.4 Hz, Ar-H), 7.96 (1H, d, J = 8.4 Hz, Ar-H), 7.72 (1H, t, J = 7.7 Hz, Ar-H), 7.50 (1H, t, J = 7.7 Hz, Ar-H), 7.50 (1H, t, J = 7.7 Hz, Ar-H), 7.08 (1H, s, Ar-H), 2.66 (3H, s, CH3), 2.07 (2H, br s, NH2).13C NMR (125 MHz, CDCl3) δ: 159.6 (Ar-C), 149.2 (Ar-C), 145.8 (Ar-C), 130.1 (Ar-CH ), 129.5 (Ar-C), 125.6 (Ar-CH), 120.5 (Ar-CH), 120.1 (Ar-CH), 109.0 (Ar-CH), 25.7 (CH3).

References

[1] Chemistry - A European Journal, 2011, vol. 17, # 35, p. 9599 - 9604
[2] Angewandte Chemie - International Edition, 2015, vol. 54, # 12, p. 3773 - 3777
[3] Angew. Chem., 2015, vol. 127, # 12, p. 3844 - 3848,5
[4] Australian Journal of Chemistry, 2015, vol. 68, # 12, p. 1842 - 1853
[5] Proceedings of the Royal Society of London, Series B: Biological Sciences, 1933, vol. 113, p. 293,298

4-AMINO-2-METHYLQUINOLINE Preparation Products And Raw materials

Raw materials

4-CHLORO-2-METHYLQUINOLINE Ammonia 1.1'-Binaphthyl-2.2'-diphemyl phosphine Sodium tert-butoxide 1,4-Dioxane

Preparation Products

4-AMINO-2-METHYLQUINOLINE Suppliers

Global( 240)Suppliers
Supplier Tel Email Country ProdList Advantage
Shandong Dinghao Biological Technology Co. LTD
+86-86-18300239 +8618300239268 sales@sddhpharm.com China 101 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427 sales@conier.com China 49979 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29640 60
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
Zhejiang ZETian Fine Chemicals Co. LTD 		+8618957127338 stella@zetchem.com China 2994 58
Shenzhen Nexconn Pharmatechs Ltd 		+86-755-89396905 +86-15013857715 admin@nexconn.com China 10403 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
Shaanxi Dideu Medichem Co. Ltd 		+8617392709771 1097@dideu.com China 3992 58
SIMAGCHEM CORP 		+86-5922680277 +86-13806087780 sale@simagchem.com China 17346 58
Hubei Ipure Biology Co., Ltd 		+8613367258412 ada@ipurechemical.com China 10236 58
Supplier Advantage
Shandong Dinghao Biological Technology Co. LTD
58
CONIER CHEM AND PHARMA LIMITED
58
Capot Chemical Co.,Ltd. 		60
ATK CHEMICAL COMPANY LIMITED 		60
Zhejiang ZETian Fine Chemicals Co. LTD 		58
Shenzhen Nexconn Pharmatechs Ltd 		58
Alchem Pharmtech,Inc. 		58
Shaanxi Dideu Medichem Co. Ltd 		58
SIMAGCHEM CORP 		58
Hubei Ipure Biology Co., Ltd 		58

View Lastest Price from 4-AMINO-2-METHYLQUINOLINE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-AMINO-2-METHYLQUINOLINE pictures 2025-12-24 4-AMINO-2-METHYLQUINOLINE
6628-04-2
 1KG 99.0% 1000 tons Shaanxi Dideu Medichem Co. Ltd
4-AMINO-2-METHYLQUINOLINE pictures 2021-10-15 4-AMINO-2-METHYLQUINOLINE
6628-04-2
 $10.00 1KG 99% 20 tons Hebei Zhanyao Biotechnology Co. Ltd
4-Aminoquinaldine pictures 2021-07-13 4-Aminoquinaldine
6628-04-2
 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd
  • 4-Aminoquinaldine pictures
  • 4-Aminoquinaldine
    6628-04-2
  • $10.00-15.00
  • 99%+ HPLC
  • Zhuozhou Wenxi import and Export Co., Ltd

4-AMINO-2-METHYLQUINOLINE Spectrum

4-AMINO-2-METHYLQUINOLINE(6628-04-2)MS4-AMINO-2-METHYLQUINOLINE(6628-04-2)1HNMR4-AMINO-2-METHYLQUINOLINE(6628-04-2)IR14-AMINO-2-METHYLQUINOLINE(6628-04-2)IR24-AMINO-2-METHYLQUINOLINE(6628-04-2)Raman

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LABOTEST-BB LT02084860 AKOS AUF2104 4-AMINO-2-METHYLQUINOLINE TIMTEC-BB SBB003992 2-Methyl-4-quinolinamine 4-Quinolinamine, 2-methyl- 2-METHYLQUINOLIN-4-YLAMINE Dequalinium Impurity 1（Dequalinium EP Impurity A） 4-Aminoquinaldine,98% 4-AMINO-2-METHYLQUINOLINE 98% 2-Methyl-4-aminoquinoline 4-AMinoquinald 4-Quinaldinamine NSC 60281 4-Amino-2-methylquinoline > 4-Amino-2-methylchinolin 4-AMINO-2-METHYLQUINOLINE ISO 9001：2015 REACH Dequalinium Chloride EP Impurity AQ: What is Dequalinium Chloride EP Impurity A Q: What is the CAS Number of Dequalinium Chloride EP Impurity A 5-4-Aminoquinaldine C10225000 4-Aminoquinaldine Dequalinium Impurity 1 2-Methyl-5-chloro-8-hydroxyquinoline 2-Methylquinolin-4-amine (Dequalinium Impurity) 2-METHYLQUINOLIN-4-AMINE 4-AMINOQUINALDINE 6628-04-2 6628-4-2 Building Blocks Aminoquinolines Alkylquinolines Quinolines Heterocyclic Building Blocks Quinaldines Alkylquinolines Aminoquinolines quinoline Quinolines Building Blocks Chemical Synthesis Heterocyclic Building Blocks Quinaldines