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Triprolidine hydrochloride

Triprolidine hydrochloride structure

CAS No.: 6138-79-0

Chemical Name:: Triprolidine hydrochloride

Synonyms: rate,stereoisomer;TRIPROLIDINE HCL USP;trans-TriprolidineHCl;Tripolidine Hydrochloride;Triprolidine hydrochloride;Triprolidine Hydrochlorise;TRIPROLIDINE HCL MONOHYDRATE;TRIPROLIDINEHYDROCHLORIDE,USP;Triprolidine hydrochloride (347);triprolidinesigmareferencestandard

CBNumber:: CB6232533

Molecular Formula:: C19H23ClN2

Molecular Weight:: 314.85

MDL Number:: MFCD00150574

MOL File:: 6138-79-0.mol

MSDS File:: SDS

Last updated:2026-01-20 10:51:09

Product description	Number	Pack Size	Price
Triprolidine hydrochloride ≥99%	T6764	1g	$46.8
Triprolidine PharmaceuticalSecondaryStandard;CertifiedReferenceMaterial	PHR2662	500MG	$205.2
Triprolidine hydrochloride British Pharmacopoeia (BP) Reference Standard	BP347	100MG	$272
Triprolidine hydrochloride United States Pharmacopeia (USP) Reference Standard	1696007	300mg	$413
Triprolidine hydrochloride solution 1?mg/mL in methanol ((as free base)), certified reference material, ampule of 1?mL, Cerilliant?	T-140	1ML	$88.7
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Triprolidine hydrochloride Properties

Melting point	115-120°C
storage temp.	2-8°C
solubility	alcohol: soluble1 in 1.5 of solvent
form	Solid
color	White to Off-White
Water Solubility	>=10 g/100 mL at 20 ºC
Merck	13,9817
Stability	Stable, but discolours in light. Incompatible with strong oxidizing agents.
InChI	InChI=1S/C19H22N2.ClH/c1-16-7-9-17(10-8-16)18(19-6-2-3-12-20-19)11-15-21-13-4-5-14-21;/h2-3,6-12H,4-5,13-15H2,1H3;1H/b18-11+;
InChIKey	WYUYEJNGHIOFOC-NWBUNABESA-N
SMILES	C(=C/CN1CCCC1)(\C1=NC=CC=C1)/C1C=CC(C)=CC=1.Cl
LogP	4.223 (est)
FDA 21 CFR	341.12
CAS DataBase Reference	6138-79-0(CAS DataBase Reference)
FDA UNII	YAN7R5L890
EPA Substance Registry System	Pyridine, 2-[1-(4-methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl]-, monohydrochloride, monohydrate, (E)- (6138-79-0)
UNSPSC Code	41116107
NACRES	NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P264-P270-P301+P312-P302+P352-P305+P351+P338
target organs	Respiratory system
PPE	dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes	Xn
Risk Statements	22-36/37/38
Safety Statements	26-36
WGK Germany	3
RTECS	UT7658000
HS Code	2933399090
Storage Class	11 - Combustible Solids
Hazard Classifications	Acute Tox. 4 Oral Eye Irrit. 2 Skin Irrit. 2 STOT SE 3

Triprolidine hydrochloride price More Price(13)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	T6764	Triprolidine hydrochloride ≥99%	6138-79-0	1g	$46.8	2025-07-31	Buy
Sigma-Aldrich	PHR2662	Triprolidine PharmaceuticalSecondaryStandard;CertifiedReferenceMaterial	6138-79-0	500MG	$205.2	2025-07-31	Buy
Sigma-Aldrich	BP347	Triprolidine hydrochloride British Pharmacopoeia (BP) Reference Standard	6138-79-0	100MG	$272	2025-07-31	Buy
Sigma-Aldrich	1696007	Triprolidine hydrochloride United States Pharmacopeia (USP) Reference Standard	6138-79-0	300mg	$413	2025-07-31	Buy
Sigma-Aldrich	T-140	Triprolidine hydrochloride solution 1?mg/mL in methanol ((as free base)), certified reference material, ampule of 1?mL, Cerilliant?	6138-79-0	1ML	$88.7	2022-05-15	Buy

Product number	Packaging	Price	Buy
T6764	1g	$46.8	Buy
PHR2662	500MG	$205.2	Buy
BP347	100MG	$272	Buy
1696007	300mg	$413	Buy
T-140	1ML	$88.7	Buy

Triprolidine hydrochloride Chemical Properties,Uses,Production

Chemical Properties

TRIPROLIDINE HYDROCHLORIDE is a white, crystalline powder.

Uses

TRIPROLIDINE HYDROCHLORIDE is used as bulk pharmaceutical (antihistaminic). Product Data Sheet

Uses

anticholinergic (opthalmic)

Uses

trans-Triprolidine Hydrochloride is a potent H1 receptor antagonist. Anti-histamines.

Definition

TRIPROLIDINE HYDROCHLORIDE is a hydrate that is the monohydrate form of triprolidine hydrochloride. A sedating antihistamine, it is used for the symptomatic relief of uticaria, rhinitis, and various pruritic skin disorders.

brand name

Actidil (GlaxoSmithKline); Myidyl (USl).

General Description

Triprolidine hydrochloride,(E)-2-[3-(1-pyrrolidinyl)-1-p-tolylpropenyl]pyridine monohydrochloridemonohydrate (Actidil), is a white crystalline powder with a slight, but unpleasant, odor. It is soluble inwater and in alcohol, and its solutions are alkaline to litmus.
The antihistaminic activity is confined mainly to the geometricisomer in which the pyrrolidinomethyl group is transto the 2-pyridyl group. Pharmacological studies confirm thehigh activity of triprolidine and the superiority of (E) overcorresponding (Z) isomers as H1-antihistamines. At guineapig ileum sites, the affinity of triprolidine for H-receptorswas more than 1,000 times the affinity of its (Z) diasteromer.The relative potency of triprolidine is of the same orderas that of dexchlorpheniramine. The peak effect occursabout 3.5 hours after oral administration, and the duration ofeffect is about 12 hours.

General Description

Odorless white crystalline powder. Bitter taste.

Air & Water Reactions

Water soluble.

Reactivity Profile

Triprolidine hydrochloride discolors on exposure to light.

Health Hazard

SYMPTOMS: Symptoms of exposure to Triprolidine hydrochloride may include depression to stimulation of the central nervous system, dry mouth, fixed dilated pupils, flushing, hallucinations, convulsions, urinary retention, cardiac arrhythmias and coma. Other symptoms may include excitability, drowsiness, nervousness, dizziness, high fever and sleeplessness. It can also cause sedation. It may also cause local anesthesia, dryness of the throat and nose and abdominal pain with vomiting or diarrhea.

Fire Hazard

Flash point data for Triprolidine hydrochloride are not available; however, Triprolidine hydrochloride is probably combustible.

Biological Activity

Potent H 1 receptor antagonist.

Triprolidine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

Triprolidine hydrochloride Suppliers

Global( 179)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49977	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29795	58
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32470	58
Shaanxi Dideu Medichem Co. Ltd	+86-029-89586680 +86-18192503167	1026@dideu.com	China	7099	58
AFINE CHEMICALS LIMITED	+86-0571-85134551	sales@afinechem.com	China	15080	58
Wuhan Fortuna Chemical Co., Ltd	+86-027-59207850 +86-13986145403;	info@fortunachem.com	China	6009	58
Baoji Guokang Healthchem Co., Ltd.	+86-0917-3909592 +86-13892490616	gksales1@gk-bio.com	China	9206	58
CD Chemical Group Limited	+8615986615575	info@codchem.com	China	17259	58
TargetMol Chemicals Inc.	+1-781-999-5354;	support@targetmol.com	United States	39042	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8467	58

Supplier	Advantage
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
TargetMol Chemicals Inc.	58
Shaanxi Dideu Medichem Co. Ltd	58
AFINE CHEMICALS LIMITED	58
Wuhan Fortuna Chemical Co., Ltd	58
Baoji Guokang Healthchem Co., Ltd.	58
CD Chemical Group Limited	58
TargetMol Chemicals Inc.	58
Wuhan Topule Biopharmaceutical Co., Ltd	58

View Lastest Price from Triprolidine hydrochloride manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-02-05	Triprolidine hydrochloride 6138-79-0	US $0.00 / KG Ton	1KG Ton	USP4398%+	2 tons/month	ZHUHAI HRD PHARMACEUTICAL CO., LTD.
2026-02-03	Triprolidine hydrochloride 6138-79-0	US $0.00-0.00 / Kg/Drum	1KG	98%-101%	100KG	WUHAN FORTUNA CHEMICAL CO., LTD
2026-01-31	Triprolidine hydrochloride monohydrate 6138-79-0	US $30.00-97.00 / mg		99.68%	10g	TargetMol Chemicals Inc.

Triprolidine hydrochloride
6138-79-0
US $0.00 / KG Ton
USP4398%+
ZHUHAI HRD PHARMACEUTICAL CO., LTD.

Triprolidine hydrochloride
6138-79-0
US $0.00-0.00 / Kg/Drum
98%-101%
WUHAN FORTUNA CHEMICAL CO., LTD

Triprolidine hydrochloride monohydrate
6138-79-0
US $30.00-97.00 / mg
99.68%
TargetMol Chemicals Inc.

Triprolidine hydrochloride Spectrum

Triprolidine hydrochloride(6138-79-0)¹HNMR Triprolidine hydrochloride(6138-79-0)IR

6138-79-0(Triprolidine hydrochloride)Related Search:

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Triprolidine Hydrochloride (500 mg) Triprolidine Hydrochloride (300 mg) TRIPROLIDINE HYDROCHLORIDE MONOHYDRATE pyridine,2-(3-(1-pyrrolidinyl)-1-p-tolylpropenyl)-,monohydrochloride,monohyd Pyridine,2-[3-(1-pyrrolidinyl)-1-p-tolylpropenyl]-,monohydrochloride,monohydrate,stereoisomer rate,stereoisomer triprolidinesigmareferencestandard Pyridine, 2-(1E)-1-(4-methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl-, monohydrochloride, monohydrate TRIPROLIDINEHYDROCHLORIDE,USP 2-[(1E)-1-(4-Methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl]pyridine hydrochloride monohydrate Tripolidine Hydrochloride TRIPROLIDINE HCL USP TRIPROLIDINE HCL MONOHYDRATE trans-TriprolidineHCl (E)-2-[3-(1-Pyrrolidinyl)-1-p-tolylpropenyl]pyridine hydrochloride, trans-2-[3-(1-Pyrrolidinyl)-1-p-tolylpropenyl]pyridine hydrochloride trans-1-(2-pyridyl)-3-pyrrolidino-1-p-tolylprop-1-ene hydrochloride monohydrate trans-2-[3-(1-pyrrolidinyl)-1-p-tolylpropenyl]pyridine hydrochloride monohydrate (E)-2-[3-(1-Pyrrolidinyl)-1-p-tolylpropenyl]pyridine hydrochloride 2-(1-(4-Methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl)pyridine monohydrochloride Triprolidine hydrochloride 2-[(E)-1-(4-Methylphenyl)-3-pyrrolidin-1-ylprop-1-enyl]pyridine hydrate hydrochloride 2-[1-(4-Methylphenyl)-3-(2,3,4,5-tetrahydropyrrol-1-yl)prop-1-enyl]pyridine chloride hydrate Triprolidine hydrochloride,(E)-2-[3-(1-Pyrrolidinyl)-1-p-tolylpropenyl]pyridine hydrochloride, trans-2-[3-(1-Pyrrolidinyl)-1-p-tolylpropenyl]pyridine hydrochloride Triprolidine Hydrochlorise 2-[(1E)-1-(4-methylphenyl)-3-(pyrrolidin-1-yl)prop1-en-1-yl]pyridine hydrate hydrochloride Triprolidine hydrochloride USP/EP/BP (E)-2-(3-(Pyrrolidin-1-yl)-1-(p-tolyl)prop-1-en-1-yl)pyridine hydrochloride hydrate Triprolidine hydrochloride (347) Triprolidine Hydrochloride (1696007) Triprolidine hydrochloride monohydrate, 10 mM in DMSO Triprolidine hydrochloride solution 6138-79-0 C19H22N2ClHH2O C19H23N2ClH2O C19H22N2HClH2O MYRDRIACYL Bulk Pharmaceuticals