RESIQUIMOD
- CAS No.
- 144875-48-9
- Chemical Name:
- RESIQUIMOD
- Synonyms
- R0197;VML600;CS-2796;VML 600;VML-600;Leisimot;resquimod;resiquimo;RESIQUIMOD;Chebi:36706
- CBNumber:
- CB62446527
- Molecular Formula:
- C17H22N4O2
- Molecular Weight:
- 314.38
- MDL Number:
- MFCD00937759
- MOL File:
- 144875-48-9.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Resiquimod ≥98% (HPLC) | SML0196 | 10mg | $131 |
| Resiquimod ≥98% (HPLC) | SML0196 | 50mg | $493.05 |
| Resiquimod >98.0%(HPLC) | R0197 | 25mg | $101 |
| Resiquimod >98.0%(HPLC) | R0197 | 100mg | $296 |
| R-848 ≥98% | 14806 | 5mg | $49 |
| More product size | |||
| Melting point | 190-193° |
|---|---|
| Boiling point | 553.6±50.0 °C(Predicted) |
| Density | 1.28 |
| storage temp. | -20°C |
| solubility | DMSO: soluble10mg/mL, clear (warmed to 60 °C) |
| form | powder |
| pka | 14.63±0.29(Predicted) |
| color | white to tan |
| λmax | 325nm(lit.) |
| Merck | 14,8151 |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months. |
| InChI | InChI=1S/C17H22N4O2/c1-4-23-9-13-20-14-15(21(13)10-17(2,3)22)11-7-5-6-8-12(11)19-16(14)18/h5-8,22H,4,9-10H2,1-3H3,(H2,18,19) |
| InChIKey | BXNMTOQRYBFHNZ-UHFFFAOYSA-N |
| SMILES | C12=C(C(=NC3C=CC=CC1=3)N)N=C(COCC)N2CC(O)(C)C |
| NCI Dictionary of Cancer Terms | resiquimod |
| FDA UNII | V3DMU7PVXF |
| NCI Drug Dictionary | resiquimod |
| UNSPSC Code | 51111800 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS06,GHS08 |
|---|---|
| Signal word | Danger |
| Hazard statements | H301-H350 |
| Precautionary statements | P501-P270-P202-P201-P264-P280-P308+P313-P301+P310+P330-P405 |
| WGK Germany | 3 |
| RTECS | NJ5911320 |
| HS Code | 2933998090 |
RESIQUIMOD price More Price(46)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0196 | Resiquimod ≥98% (HPLC) | 144875-48-9 | 10mg | $131 | 2025-07-31 | Buy |
| Sigma-Aldrich | SML0196 | Resiquimod ≥98% (HPLC) | 144875-48-9 | 50mg | $493.05 | 2025-07-31 | Buy |
| TCI Chemical | R0197 | Resiquimod >98.0%(HPLC) | 144875-48-9 | 25mg | $101 | 2025-07-31 | Buy |
| TCI Chemical | R0197 | Resiquimod >98.0%(HPLC) | 144875-48-9 | 100mg | $296 | 2025-07-31 | Buy |
| Cayman Chemical | 14806 | R-848 ≥98% | 144875-48-9 | 5mg | $49 | 2024-03-01 | Buy |
RESIQUIMOD Chemical Properties,Uses,Production
Description
Resiquimod (CAS 144875-48-9) is a Toll-like receptor 7/8 agonist.1 May be used as an immune adjuvant in cancer vaccines.2 Resiquimod-carrying synthetic vaccine particles augment the immune response to encapsulated antigen and exhibit strong local immune activation without inducing systemic cytokine release.3 Topical treatment of wild-type mice induces systemic autoimmune disease which may be used as a model of systemic Lupus erythematosus.4? It displayed potent antiviral activity (EC50 = 23.5 nM) in a murine norovirus replicon model.5
Uses
Resiquimod is an imidazoquinoline derivative that acts as an immune response modifier. Resiquimod shows antitumor and antiviral activity and is used in the treatment of skin lesions such as herpes simplex virus. Resiquimod is a toll-like receptor 9 (TLR7) agonist.
Uses
Resiquimod has been used in the stimulation of bone marrow-derived dendritic cells (BMDCs) stimulation( and B cells. It has also been used as a ligand for toll-like receptors (TLR7) in malignant melanoma cell line B16F10.
Definition
ChEBI: Resiquimod is an imidazoquinoline.
Biochem/physiol Actions
Resiquimod belongs to the class of imidazoquinolinamines compounds with immunomodulatory effects. Resiquimod increases the levels of cytokines such as TNF-α, IL-6 and IFN-α.
Synthesis
![N-{2-chloro-4-[(2-hydroxy-2-methylpropyl)amino]quinolin-3-yl}-2-ethoxyacetamide](/CAS/20200401/GIF/253120-65-9.gif)
253120-65-9
144875-48-9
Preparation of R-848: A mixture of 2-amino-2-methyl-1-propanol (1.87 g, 5.3 mmol) and methanol was placed in an autoclave, sealed and then the reaction was stirred at 160 °C for 8 hours. After completion of the reaction, the solvent was removed by distillation under reduced pressure and the resulting residue was purified by silica gel column chromatography (eluent: ethyl acetate/triethylamine=95:5) to finally obtain the target product R-848 (1.5 g).
storage
Store at +4°C
References
[1] MARION JURK. Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848[J]. Nature Immunology, 2002, 3 6: 499-499. DOI:10.1038/ni0602-499
[2] RACHEL LUBONG SABADO. Resiquimod as an immunologic adjuvant for NY-ESO-1 protein vaccination in patients with high-risk melanoma.[J]. Cancer immunology research, 2015, 3 3: 278-287. DOI:10.1158/2326-6066.cir-14-0202
[3] PETR O. ILYINSKII . Adjuvant-carrying synthetic vaccine particles augment the immune response to encapsulated antigen and exhibit strong local immune activation without inducing systemic cytokine release[J]. Vaccine, 2014, 32 24: Pages 2882-2895. DOI:10.1016/j.vaccine.2014.02.027
[4] MAKI YOKOGAWA. Epicutaneous Application of Toll-like Receptor 7 Agonists Leads to Systemic Autoimmunity in Wild-Type Mice: A New Model of Systemic Lupus Erythematosus[J]. Arthritis & Rheumatology, 2013, 66 3: 694-706. DOI:10.1002/art.38298
[5] DANIEL ENOSI TUIPULOTU. TLR7 Agonists Display Potent Antiviral Effects against Norovirus Infection via Innate Stimulation.[J]. Antimicrobial Agents and Chemotherapy, 2018. DOI:10.1128/aac.02417-17
RESIQUIMOD Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 965 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22963 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19552 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49975 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29799 | 58 |
| Jinan Liheng Biotechnology Co., Ltd. | 15865262812 | info@lihengpharm.com | CHINA | 938 | 58 |
View Lastest Price from RESIQUIMOD manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-10-20 | Resiquimod
144875-48-9
|
US $30.00-79.00 / mg | 99.67% | 10g | TargetMol Chemicals Inc. | ||
 |
2021-11-27 | RESIQUIMOD
144875-48-9
|
US $120.00 / g | 100g | 99.99% | 5ton/Month | Qiuxian Baitai New Material Co., LTD | |
 |
2021-07-13 | Resiquimod
144875-48-9
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
-
- Resiquimod
144875-48-9
- US $30.00-79.00 / mg
- 99.67%
- TargetMol Chemicals Inc.
-
- RESIQUIMOD
144875-48-9
- US $120.00 / g
- 99.99%
- Qiuxian Baitai New Material Co., LTD
-
- Resiquimod
144875-48-9
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
