3-CYCLOPENTYLACRYLONITRILE
- CAS No.
- 591769-05-0
- Chemical Name:
- 3-CYCLOPENTYLACRYLONITRILE
- Synonyms
- (E)-3-cyclopentylacrylonitrile;(2E)-3-Cyclopentylacrylonitrile;(E)-3-cyclopentylprop-2-enenitrile;Ruxolitinib Impurity 31;3-CYCLOPENTYLACRYLONITRILE;3-cyyclopentylacrylonitrile;2-Propenenitrile,3-cyclopenty;3-CYCLOPENTYLACRYLONITRILE CAS;3-cyclopentyl-2-Propenenitrile;3-cyclopentylprop-2-enenitrile
- CBNumber:
- CB62467070
- Molecular Formula:
- C8H11N
- Molecular Weight:
- 121.18
- MDL Number:
- MFCD11857755
- MOL File:
- 591769-05-0.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 3-Cyclopentylacrylonitrile Aldrich | ADE001298 | 1g | $1260 |
| 3-Cyclopentylacrylonitrile | FC148590 | 10g | $235.6 |
| 3-Cyclopentylacrylonitrile | FC148590 | 25g | $392.75 |
| 3-Cyclopentylacrylonitrile | FC148590 | 50g | $628.5 |
| 3-Cyclopentylacrylonitrile | FC148590 | 100g | $865 |
| More product size | |||
| Boiling point | 209.0±9.0 °C(Predicted) |
|---|---|
| Density | 1.027±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| form | solid |
| Appearance | Colorless to light yellow Liquid |
| InChI | InChI=1S/C8H11N/c9-7-3-6-8-4-1-2-5-8/h3,6,8H,1-2,4-5H2 |
| InChIKey | VMELXYJYSXXORF-UHFFFAOYSA-N |
| SMILES | C(#N)C=CC1CCCC1 |
| UNSPSC Code | 12352200 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
| WGK Germany | 3 |
| HazardClass | IRRITANT |
| HS Code | 2926907090 |
| Storage Class | 11 - Combustible Solids |
| REACH Registrations | Active |
3-CYCLOPENTYLACRYLONITRILE price More Price(43)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | ADE001298 | 3-Cyclopentylacrylonitrile Aldrich | 591769-05-0 | 1g | $1260 | 2024-03-01 | Buy |
| Biosynth | FC148590 | 3-Cyclopentylacrylonitrile | 591769-05-0 | 10g | $235.6 | 2026-06-04 | Buy |
| Biosynth | FC148590 | 3-Cyclopentylacrylonitrile | 591769-05-0 | 25g | $392.75 | 2026-06-04 | Buy |
| Biosynth | FC148590 | 3-Cyclopentylacrylonitrile | 591769-05-0 | 50g | $628.5 | 2026-06-04 | Buy |
| Biosynth | FC148590 | 3-Cyclopentylacrylonitrile | 591769-05-0 | 100g | $865 | 2026-06-04 | Buy |
3-CYCLOPENTYLACRYLONITRILE Chemical Properties,Uses,Production
Uses
3-Cyclopentylacrylonitrile and its derivatives are used in the preparation of ruxolitinib intermediates and trasitinib phosphate. It is associated with diseases such as thrombocytosis, true erythrocytosis and primary myelofibrosis.
Synthesis
872-53-7
2537-48-6
591769-05-0
Step 1. A solution of diethyl cyanomethylphosphate (39.9 mL, 0.246 mol) in THF (300 mL) was added slowly and dropwise to a solution of 1.0 M potassium tert-butoxide in THF (235 mL) at 0 °C. The ice bath was removed and the reaction mixture was gradually warmed to room temperature and subsequently cooled to 0 °C again. At this temperature, a solution of cyclopentyl formaldehyde (22.0 g, 0.224 mol) in THF (60 mL) was added slowly and dropwise. The ice bath was removed and the reaction mixture was warmed to ambient temperature and stirred continuously for 64 hours. Upon completion of the reaction, the mixture was partitioned between ether and water, and the aqueous phase was extracted three times with ether followed by two extractions with ethyl acetate. The organic phases were combined, washed with brine, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give 24.4 g (89% yield) of a mixture of (2E)- and (2Z)-3-cyclopentylacrylonitrile, which was used in the subsequent steps without further purification.1H NMR (400 MHz, CDCl3): δ 6.69 (dd, 1H, trans olefin), 6.37 (t, 1H, cis-olefin), 5.29 (dd, 1H, trans-olefin), 5.20 (d, 1H, cis-olefin), 3.07-2.95 (m, 1H, cis-product), 2.64-2.52 (m, 1H, trans-product), 1.98-1.26 (m, 16H).
References
[1] Journal of Catalysis, 2003, vol. 218, # 1, p. 191 - 200
[2] Patent: EP2349260, 2016, B1. Location in patent: Paragraph 0111
[3] Patent: CN105418616, 2016, A. Location in patent: Paragraph 0110; 0111
[4] Patent: WO2011/31554, 2011, A2. Location in patent: Page/Page column 147-148
3-CYCLOPENTYLACRYLONITRILE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Zhejiang ZETian Fine Chemicals Co. LTD | 18957127338 | stella@zetchem.com | China | 2993 | 58 |
| Wuhan Fortuna Chemical Co., Ltd | +86-27-59207850 | info@fortunachem.com | China | 5998 | 58 |
| Hangzhou ICH Biofarm Co., Ltd | +86-0571-28186870; +undefined8613073685410 | sales@ichemie.com | China | 1002 | 58 |
| Hebei Xinsheng New Material Technology Co., LTD. | +86-16632316109 | xinshengkeji@xsmaterial.com | China | 1082 | 58 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 14032 | 58 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1796 | 55 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21531 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32998 | 60 |
| Changzhou Ansciep Chemical Co., Ltd. | +86 519 86305871 | sales@ansciepchem.com | CHINA | 4241 | 58 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 8491 | 58 |
View Lastest Price from 3-CYCLOPENTYLACRYLONITRILE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-14 | 3-CYCLOPENTYLACRYLONITRILE
591769-05-0
|
20kg | 99% | 1000kg | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2026-08-08 | 3-CYCLOPENTYLACRYLONITRILE
591769-05-0
|
1kg | 99% | 500KG | Hangzhou ICH Biofarm Co., Ltd | ||
 |
2026-06-30 | 3-CYCLOPENTYLACRYLONITRILE
591769-05-0
|
1KG | 98.0% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd |
-
- 3-CYCLOPENTYLACRYLONITRILE
591769-05-0
- 99%
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- 3-CYCLOPENTYLACRYLONITRILE
591769-05-0
- 99%
- Hangzhou ICH Biofarm Co., Ltd
-
- 3-CYCLOPENTYLACRYLONITRILE
591769-05-0
- 98.0%
- Shaanxi Dideu New Materials Co. Ltd
