Methyl 2-chloro-5-fluoro-6-methoxynicotinate
- CAS No.
- 959616-64-9
- Chemical Name:
- Methyl 2-chloro-5-fluoro-6-methoxynicotinate
- Synonyms
- Methyl 2-chloro-5-fluoro-6-methoxynicotinate;2-Chloro-5-fluoro-6-methoxy-nicotinic acid methyl ester;Methyl 2-chloro-5-fluoro-6-methoxy-pyridine-3-carboxylate;Methyl 2-chloro-5-fluoro-6-methoxynicotinate ISO 9001：2015 REACH;3-Pyridinecarboxylic acid, 2-chloro-5-fluoro-6-methoxy-, methyl ester;Methyl 2-chloro-5-fluoro-6-methoxypyridine-3-carboxylate, 2-Chloro-5-fluoro-6-methoxy-3-(methoxycarbonyl)pyridine
- CBNumber:
- CB62481685
- Molecular Formula:
- C8H7ClFNO3
- Molecular Weight:
- 219.6
- MDL Number:
- MFCD12025844
- MOL File:
- 959616-64-9.mol
- MSDS File:
- SDS
| Melting point | 66-68° |
|---|---|
| Boiling point | 279.8±40.0 °C(Predicted) |
| Density | 1.366±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| pka | -3.47±0.10(Predicted) |
| Appearance | white solid |
| InChI | InChI=1S/C8H7ClFNO3/c1-13-7-5(10)3-4(6(9)11-7)8(12)14-2/h3H,1-2H3 |
| InChIKey | KGWMUWXJNVKKCF-UHFFFAOYSA-N |
| SMILES | C1(Cl)=NC(OC)=C(F)C=C1C(OC)=O |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319 |
| Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 |
| HazardClass | IRRITANT |
| HS Code | 2933399990 |
Methyl 2-chloro-5-fluoro-6-methoxynicotinate price More Price(44)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | OR43597 | Methyl 2-chloro-5-fluoro-6-methoxynicotinate 98% | 959616-64-9 | 250mg | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR43597 | Methyl 2-chloro-5-fluoro-6-methoxynicotinate 98% | 959616-64-9 | 1g | $39 | 2026-06-04 | Buy |
| Apolloscientific | OR43597 | Methyl 2-chloro-5-fluoro-6-methoxynicotinate 98% | 959616-64-9 | 5g | $151 | 2026-06-04 | Buy |
| Apolloscientific | OR43597 | Methyl 2-chloro-5-fluoro-6-methoxynicotinate 98% | 959616-64-9 | 25g | $746 | 2026-06-04 | Buy |
| Synthonix | M0637 | Methyl 2-chloro-5-fluoro-6-methoxy-pyridine-3-carboxylate 97.0% | 959616-64-9 | 1g | $45 | 2026-05-06 | Buy |
Methyl 2-chloro-5-fluoro-6-methoxynicotinate Chemical Properties, Uses, Production
Synthesis
189281-66-1
124-41-4
959616-64-9
Intermediate 73b: Synthesis of methyl 2-chloro-5-fluoro-6-methoxypyridine-3-carboxylate. Sodium methanol (1.86 mL, 11.91 mmol) was added to a solution of toluene (9 mL) containing methyl 2,6-dichloro-5-fluoropyridine-3-carboxylate (1.8 g, 8.03 mmol), and the reaction mixture was stirred for 1 h at room temperature. After completion of the reaction, ethyl acetate (20 mL) and water (20 mL) were added to the mixture to separate the organic and aqueous layers. The aqueous layer was extracted with ethyl acetate (3 x 20 mL), the organic phases were combined, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to afford the target product methyl 2-chloro-5-fluoro-6-methoxypyridine-3-carboxylate (1.72 g, 7.83 mmol, 97% yield) as an orange solid. The product was confirmed by 1H NMR (CDCl3, 400 MHz): δ 7.92 (1H, d, J = 9.6 Hz), 4.09 (3H, s), 3.92 (3H, s). Mass spectrometry analysis (Method 2): retention time 1.71 min, m/z 220.0 [M + H]+.
References
[1] Patent: WO2016/51193, 2016, A1. Location in patent: Paragraph 00667; 00670; 00671
[2] Patent: EP2022793, 2009, A1. Location in patent: Page/Page column 72
Methyl 2-chloro-5-fluoro-6-methoxynicotinate Preparation Products And Raw materials
Raw materials
Preparation Products
Methyl 2-chloro-5-fluoro-6-methoxynicotinate Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Suzhou Nuoouman Biological Technology Co., Ltd. | 15026866316 | 180642609@qq.com | China | 4966 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| PharmaBlock Sciences (Nanjing),Inc. | 025-86918202 4000255188 | sales@pharmablock.com | China | 5000 | 55 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Chiba Pharmaceutical Science and technology Co, Ltd. | 0531-81313138 13066006660 | chibapharm@foxmail.com | China | 3996 | 55 |
| Shanghai Jian Chao Chemical Technology Co., Ltd. | 150-2103-5486 18017383231 | 983544897@qq.com | China | 9335 | 55 |
| ShangHai AmK Pharmaceutical Technology Co., Ltd. | 微信 18019252918 18019252918 | sale@amkchem.com | China | 14982 | 55 |
| Nanjing YiFan Biological Technology Co., Ltd. | 025-025-52700520 18914499889 | sales@yfbiotech.com | China | 494 | 58 |
| Cool Pharm, Ltd | 021-60455363 18019463053 | sales@coolpharm.com | China | 8455 | 58 |
| SPIRO PHARMA | eric_feng1954@126.com | China | 9239 | 55 |
View Latest Price from Methyl 2-chloro-5-fluoro-6-methoxynicotinate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-03 | Methyl 2-chloro-5-fluoro-6-methoxynicotinate
959616-64-9
|
$6.60 | 1KG | 97%-99% | 1kg -1000kg | Career Henan Chemical Co |
-
- Methyl 2-chloro-5-fluoro-6-methoxynicotinate
959616-64-9
- $6.60
- 97%-99%
- Career Henan Chemical Co
