7-hydroxy-2-methyl-4H-chromen-4-one
- CAS No.
- 6320-42-9
- Chemical Name:
- 7-hydroxy-2-methyl-4H-chromen-4-one
- Synonyms
- NSC 31894;Hymecromone EP Impurity B;7-Hydroxy-2-methylchromone;7-hydroxy-2-methylchromen-4-one;7-Hydroxy-2-methyl-4H-1-benzopyran-;7-hydroxy-2-methyl-1-benzopyran-4-one;7-Hydroxy-2-Methyl-4H-1-benzopyran-4-one;4H-1-Benzopyran-4-one, 7-hydroxy-2-Methyl-;Hymecromone Impurity 2 (Hymecromone EP Impurity B)
- CBNumber:
- CB62490146
- Molecular Formula:
- C10H8O3
- Molecular Weight:
- 176.17
- MDL Number:
- MFCD00208225
- MOL File:
- 6320-42-9.mol
- MSDS File:
- SDS
| Melting point | 254-255℃ |
|---|---|
| Boiling point | 345.5±42.0 °C(Predicted) |
| Density | 1.319±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Room Temperature |
| pka | 7.07±0.40(Predicted) |
| Major Application | pharmaceutical (small molecule) |
| InChI | 1S/C10H8O3/c1-6-4-9(12)8-3-2-7(11)5-10(8)13-6/h2-5,11H,1H3 |
| InChIKey | QIPBSGDZHKDNNJ-UHFFFAOYSA-N |
| SMILES | [o]1c2c([c](cc1C)=O)ccc(c2)O |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319 |
| Precautionary statements | P261-P305+P351+P338 |
| WGK Germany | WGK 3 |
| Storage Class | 11 - Combustible Solids |
7-hydroxy-2-methyl-4H-chromen-4-one price More Price(28)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | Y0000013 | Hymecromone impurity B European Pharmacopoeia (EP) Reference Standard | 6320-42-9 | 25 mg | $127 | 2026-04-30 | Buy |
| Sigma-Aldrich | Y0000013 | Hymecromone impurity B European Pharmacopoeia (EP) Reference Standard | 6320-42-9 | y0000013 | $161 | 2024-03-01 | Buy |
| aablocks | AA00EFX4 | 7-hydroxy-2-methyl-4H-chromen-4-one 95% | 6320-42-9 | 100mg | $124 | 2026-05-28 | Buy |
| aablocks | AA00EFX4 | 7-hydroxy-2-methyl-4H-chromen-4-one 95.00% | 6320-42-9 | 1g | $326 | 2026-05-28 | Buy |
| aablocks | AA00EFX4 | 7-hydroxy-2-methyl-4H-chromen-4-one 95.00% | 6320-42-9 | 5g | $904 | 2026-05-28 | Buy |
7-hydroxy-2-methyl-4H-chromen-4-one Chemical Properties, Uses, Production
Uses
7-Hydroxy-2-methyl-4H-chromen-4-one is used in the synthesis of 2,2-Dimethyl-2H-pyranoflavonol and pyranochromone derivatives.
Synthesis
Step(i): 7-Acetoxy-3-acetyl-2-methylchromone
β-Resacetophenone (4.A.6) (10 g，0.066 mole) is heated with fusedsodium acetate (20 g) in acetic anhydride (30 ml) for 5 hr at 170-180°(oil bath) under anhydrous conditions. The reaction mixture is pouredover crushed ice, stirred well and left overnight.The separated product isfiltered and washed with water. It is crystallised from alcohol as light yellowneedles.Yield 10 g (58.5%).M.p.127° (lit. m.p.126-27°).
step (ii) : The above 7-acetoxy-3-acetyl-2-methylchromone (1 g,0.0038 mole) isrefluxed (2 hr) with aqueous sodium carbonate solution (10%,50 ml).Theclear solution is then acidified with hydrochloric acid (1:1).The separatedproduct is filtered and washed with water. It is crystallised from alcohol asthick prismatic crystals. Yield 0.5 g (73.5%).M.p. 249-50°.(lit. m.p.254-55°).
7-hydroxy-2-methyl-4H-chromen-4-one Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Shanghai Sinch Parmaceuticals Tech. Co. Ltd. | +86-21-54098501 | sales@sinch.com.cn | China | 11592 | 64 |
| Hangzhou Sage Chemical Co., Ltd. | +86057186818502 13588463833 | info@sagechem.com | China | 10265 | 58 |
| Nanjing Credit Trading Co.,Ltd | 025-52164950 | Googlexu_0114@sina.com | China | 644 | 58 |
| HBCChem, Inc. | +1-510-219-6317 | sales@hbcchem.com | United States | 10628 | 60 |
| ShangHai AmK Pharmaceutical Technology Co., Ltd. | 微信 18019252918 18019252918 | sale@amkchem.com | China | 14982 | 55 |
| AN PharmaTech Co Ltd | 86(21)68097365 | sales@anpharma.net | China | 4875 | 55 |
| Shanghai JingRon Chemical Technology Co., Ltd. | 021-60546673 13701861782; | kuanga111@sina.com | China | 882 | 58 |
| Shanghai Chiral bio-compound co., Ltd. | 021-5068 3667/17749785980/1029026415; 17749785980 | 1029026415@qq.com | China | 4501 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
