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1H-pyrazolo[3,4-b]pyridine-3-carbonitrile

1H-pyrazolo[3,4-b]pyridine-3-carbonitrile Structure
1H-pyrazolo[3,4-b]pyridine-3-carbonitrile structure
CAS No.
956010-88-1
Chemical Name:
1H-pyrazolo[3,4-b]pyridine-3-carbonitrile
Synonyms
1H-pyrazolo[3;Piraxostat Impurity 30;4-b]pyridine-3-carbonitrile;2H-pyrazolo[3,4-b]pyridine-3-carbonitrile;1H-pyrazolo[3,4-b]pyridine-3-carbonitrile;1H-pyrazole and [3, 4-b] pyridine-3-methyl nitrile
CBNumber:
CB62500870
Molecular Formula:
C7H4N4
Molecular Weight:
144.13
MDL Number:
MFCD13176785
MOL File:
956010-88-1.mol
MSDS File:
SDS
Last updated:2026-05-28 02:26:12
Product description Number Pack Size Price
1H-Pyrazolo[3,4-b]pyridine-3-carbonitrile >99% OR931536 100mg $21
1H-Pyrazolo[3,4-b]pyridine-3-carbonitrile >99% OR931536 250mg $24
1H-Pyrazolo[3,4-b]pyridine-3-carbonitrile >99% OR931536 1g $66
1H-Pyrazolo[3,4-b]pyridine-3-carbonitrile >99% OR931536 5g $277
1H-Pyrazolo[3,4-b]pyridine-3-carbonitrile >99% OR931536 25g $1229
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1H-pyrazolo[3,4-b]pyridine-3-carbonitrile Properties

Boiling point 397.1±22.0 °C(Predicted)
Density 1.44±0.1 g/cm3(Predicted)
storage temp. 2-8°C
pka 6.78±0.40(Predicted)
Appearance White to off-white Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P264-P270-P301+P312-P330-P501-P280-P302+P352-P321-P332+P313-P362-P305+P351+P338-P337+P313-P261-P271-P304+P340-P312-P403+P233-P405
RIDADR  UN2811
HS Code  2933998090

1H-pyrazolo[3,4-b]pyridine-3-carbonitrile price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Apolloscientific OR931536 1H-Pyrazolo[3,4-b]pyridine-3-carbonitrile >99% 956010-88-1 100mg $21 2026-06-04 Buy
Apolloscientific OR931536 1H-Pyrazolo[3,4-b]pyridine-3-carbonitrile >99% 956010-88-1 250mg $24 2026-06-04 Buy
Apolloscientific OR931536 1H-Pyrazolo[3,4-b]pyridine-3-carbonitrile >99% 956010-88-1 1g $66 2026-06-04 Buy
Apolloscientific OR931536 1H-Pyrazolo[3,4-b]pyridine-3-carbonitrile >99% 956010-88-1 5g $277 2026-06-04 Buy
Apolloscientific OR931536 1H-Pyrazolo[3,4-b]pyridine-3-carbonitrile >99% 956010-88-1 25g $1229 2026-06-04 Buy
Product number Packaging Price Buy
OR931536 100mg $21 Buy
OR931536 250mg $24 Buy
OR931536 1g $66 Buy
OR931536 5g $277 Buy
OR931536 25g $1229 Buy

1H-pyrazolo[3,4-b]pyridine-3-carbonitrile Chemical Properties,Uses,Production

Uses

1H-pyrazolo[3,4-b]pyridine-3-carbonitrile can be used to prepare SGC stimulants for the treatment of central nervous system disorders.

Synthesis

3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine

956010-87-0

1H-pyrazolo[3,4-b]pyridine-3-carbonitrile

956010-88-1

General procedure for the synthesis of 1H-pyrazolo[3,4-b]pyridine-3-carbonitrile from 3-(trifluoromethyl)-1H-pyrazolo[3,4-B]pyridine: 3-(Trifluoromethyl)-1H-pyrazolo[3,4-B]pyridine (500 mg, 2.67 mmol) was suspended in 33% ammonia solution (10 mL). The mixture was placed in a sealed tube and heated to 140 °C using microwave and maintained for 10 min. Upon completion of the reaction, the volatiles were evaporated. Ethyl acetate (100 mL) and tert-butyl methyl ether (25 mL) were added to the residue and the mixture was heated to 70 °C. The mixture was filtered while hot and the residue was washed with tert-butyl methyl ether. The filtrates were combined and evaporated to afford 1H-pyrazolo[3,4-b]pyridine-3-carbonitrile as a light yellow solid (389 mg, 90% yield), with trace amounts of the corresponding primary amide in the product. The structure of the product was determined by 1H NMR (400 MHz, DMSO-d6): δ 7.47 (dd, J = 8.2,4.5 Hz, 1H), 8.46 (dd, J = 8.2,1.5 Hz, 1H), 8.73 (dd, J = 4.5,1.5 Hz, 1H), 15.02 (br s, 1H); 13C NMR (125 MHz. DMSO-d6): δ 113.5,115.5,116.9,119.6,128.7,150.9,151.0 confirmed. High-resolution mass spectrometry (HRMS) analysis results: calculated value C7H4N4 [M]+: 144.0436; measured value: 144.0430.

References

[1] Bioorganic and Medicinal Chemistry Letters, 2013, vol. 23, # 5, p. 1197 - 1200
[2] Tetrahedron, 2015, vol. 71, # 34, p. 5597 - 5601
[3] Patent: US2010/113507, 2010, A1. Location in patent: Page/Page column 9
[4] Patent: US2010/4235, 2010, A1. Location in patent: Page/Page column 15

1H-pyrazolo[3,4-b]pyridine-3-carbonitrile Preparation Products And Raw materials

Raw materials

ZINC CYANIDE 3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine 3-Iodo-7-aza-1H-azaindazole 1H-PYRAZOLO[3,4-B]PYRIDINE, 3-BROMO- Ammonium hydroxide

Preparation Products

1H-pyrazolo[3,4-b]pyridine-3-carbonitrile Suppliers

Global( 90)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32997 60
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29766 58
Klong Industrial Co., Ltd 		0086-519-68231162 info@klongchem.com CHINA 131 58
Changzhou Ansciep Chemical Co., Ltd. 		+86 519 86305871 sales@ansciepchem.com CHINA 4241 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63645 58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		+8613580539051 joe@yuhengpharm.com CHINA 21135 58
Win-Win chemical CO., Limited 		+86-0086-577-64498589 +86-15355981851 sales@win-winchemical.com China 14301 58
Nextpeptide Inc 		+86-0571-81612335 +8613336028439 sales@nextpeptide.com China 19904 58
Hefei TNJ Chemical Industry Co.,Ltd. 		+86-0551-65418684 +86-18949823763 sales@tnjchem.com China 25333 58
Changzhou AniKare Pharmatech Co., Ltd. 		+86-0519-8359-8696 sales@anikare.com China 9993 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
Klong Industrial Co., Ltd 		58
Changzhou Ansciep Chemical Co., Ltd. 		58
Alchem Pharmtech,Inc. 		58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		58
Win-Win chemical CO., Limited 		58
Nextpeptide Inc 		58
Hefei TNJ Chemical Industry Co.,Ltd. 		58
Changzhou AniKare Pharmatech Co., Ltd. 		58

View Lastest Price from 1H-pyrazolo[3,4-b]pyridine-3-carbonitrile manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
1H-Pyrazolo[3,4-b]pyridine-3-carbonitrile pictures 2022-01-15 1H-Pyrazolo[3,4-b]pyridine-3-carbonitrile
956010-88-1
 1KG 98.7% 100 tons Honest Joy Holdings Limited
1H-pyrazolo[3,4-b]pyridine-3-carbonitrile pictures 2019-08-30 1H-pyrazolo[3,4-b]pyridine-3-carbonitrile
956010-88-1
 $1.00 1KG 98% 200kg Career Henan Chemical Co

1H-pyrazolo[3,4-b]pyridine-3-carbonitrile Spectrum

1H-pyrazolo[3,4-b]pyridine-3-carbonitrile(956010-88-1)1HNMR

956010-88-1(1H-pyrazolo[3,4-b]pyridine-3-carbonitrile)Related Search:

1H-Pyrazolo[3,4-b]pyridine-3-carboxylicacid(9CI) 1H-Pyrazolo[3,4-b]pyridine,3-methyl-(9CI) 5-Fluoro-1H-pyrazolo[3,4-b]pyridine-3-carbonitrile 6-chloro-1H-pyrazolo[3,4-b]pyridine-3-carbonitrile 1H-PYRAZOLO[3,4-B]PYRIDINE-3-CARBALDEHYDE
1H-Pyrazolo[3,4-b]pyridine-3-carboxamide

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1H-pyrazolo[3,4-b]pyridine-3-carbonitrile 1H-pyrazolo[3 4-b]pyridine-3-carbonitrile 2H-pyrazolo[3,4-b]pyridine-3-carbonitrile 1H-pyrazole and [3, 4-b] pyridine-3-methyl nitrile Piraxostat Impurity 30 956010-88-1