L-Tetrahydrofolic Acid
- CAS No.
- 135-16-0
- Chemical Name:
- L-Tetrahydrofolic Acid
- Synonyms
- TETRAHYDROFOLIC ACID;(6S)-Tetrahydrofolic acid;C00101;(6S)-Thfa;L-5,6,7,8;l-amino)benzoyl);70% when packaged);Tetrahydofolic acid;Tetrahydrofolic acide;Folic Acid Impurity 11
- CBNumber:
- CB6259109
- Molecular Formula:
- C19H23N7O6
- Molecular Weight:
- 445.43
- MDL Number:
- MFCD00135583
- MOL File:
- 135-16-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Tetrahydrofolic acid ≥65% (when packaged), powder | T3125 | 25mg | $76 |
| Tetrahydrofolic acid ≥65% (when packaged), powder | T3125 | 1g | $1070 |
| L-Tetrahydrofolic Acid (>70% when packaged) | TRC-T293515-25MG | 25mg | $258 |
| L-Tetrahydrofolic Acid (>70% when packaged) | TRC-T293515-10MG | 10mg | $142 |
| L-Tetrahydrofolic Acid (>70% when packaged) | TRC-T293515-100MG | 100mg | $513 |
| More product size | |||
| Melting point | >162°C (dec.) |
|---|---|
| Boiling point | 555.12°C (rough estimate) |
| Density | 1.4216 (rough estimate) |
| vapor pressure | 0Pa at 25℃ |
| refractive index | 1.6800 (estimate) |
| storage temp. | -20°C |
| solubility | Aqueous Base (Slightly), DMSO (Slightly), Methanol (Slightly, Heated, Sonicated) |
| form | powder |
| pka | 3.51±0.10(Predicted) |
| color | off-white to tan |
| biological source | synthetic |
| BRN | 9238187 |
| Stability | We have observed that this material decomposes steadily over time. Use immediately upon receipt. |
| InChIKey | MSTNYGQPCMXVAQ-KIYNQFGBSA-N |
| SMILES | C(O)(=O)[C@H](CCC(O)=O)NC(=O)C1=CC=C(NCC2CNC3=C(N2)C(=O)NC(N)=N3)C=C1 |
| LogP | -3.685 at 25℃ |
| FDA UNII | 43ZWB253H4 |
| UNSPSC Code | 12352204 |
| NACRES | NA.51 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P271-P280 |
| WGK Germany | 3 |
| RTECS | MA0600800 |
| F | 3-8-10 |
| HS Code | 2936290000 |
| REACH Registrations | Active |
L-Tetrahydrofolic Acid price More Price(51)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | T3125 | Tetrahydrofolic acid ≥65% (when packaged), powder | 135-16-0 | 25mg | $76 | 2026-04-30 | Buy |
| Sigma-Aldrich | T3125 | Tetrahydrofolic acid ≥65% (when packaged), powder | 135-16-0 | 1g | $1070 | 2026-04-30 | Buy |
| TRC | TRC-T293515-25MG | L-Tetrahydrofolic Acid (>70% when packaged) | 135-16-0 | 25mg | $258 | 2026-06-03 | Buy |
| TRC | TRC-T293515-10MG | L-Tetrahydrofolic Acid (>70% when packaged) | 135-16-0 | 10mg | $142 | 2026-06-03 | Buy |
| TRC | TRC-T293515-100MG | L-Tetrahydrofolic Acid (>70% when packaged) | 135-16-0 | 100mg | $513 | 2026-06-03 | Buy |
L-Tetrahydrofolic Acid Chemical Properties,Uses,Production
Chemical Properties
Light Tan Solid
Uses
L-Tetrahydrofolic Acid is a folic acid derivative and coenzyme involved in the metabolism of amino and nucleic acids. We have observed that this material decomposes steadily over time. Use immediately upon receipt.
Uses
Tetrahydrofolic acid has been used to determine the inhibitory effect of tetrahydrofolate on polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs). A recent use of tetrahydrofolate (THF) is for studying the activation of riboswitches.
Uses
Asa folic acid derivative and coenzyme, L-Tetrahydrofolic Acid can be involved in the metabolism of amino and nucleic acids.
Definition
ChEBI: A derivative of folic acid in which the pteridine ring is fully reduced; it is the parent compound of a variety of coenzymes that serve as carriers of one-carbon groups in metabolic reactions.
Flammability and Explosibility
Not classified
Biochem/physiol Actions
Tetrahydrofolic acid is the parent molecule of the folate derivatives that donate one-carbon units to amino acids, nucleic acids, and lipids. Tetrahydrofolate metabolites participate in the synthesis of purine and pyrimidine and in synthesis and conversion of amino acids
Synthesis
Tetrahydrofolate is a reduced derivative of folic acid, a coenzyme obtained by the reduction of dihydrofolate by dihydrofolate reductase.
Purification Methods
Very high quality material is now available commercially, and it should be a white powder. It can be dried over P2O5 in a vacuum desiccator and stored in weighed aliquots in sealed ampoules. It is stable at room temperature in sealed ampoules for many months and for much more extended periods at -10o. When moist, it is extremely sensitive to air whereby it oxidises to the yellow 7,8-dihydro derivative. In solution it turns yellow in colour as it oxidises, and then particularly in the presence of acids it turns dark reddish brown in colour. Hence aqueous solutions should be frozen immediately when not in use. It is always advisable to add 2-mercaptoethanol (if it does not interfere with the procedure for which it is used) which stabilises it by depleting the solution of O2. The sulfate salt is more stable but is much less soluble. The best way to prepare standard solutions of this acid is to dissolve it in the desired buffer and estimate the concentration by UV absorption in pH 7 buffer at 297nm ( 22,000 M-1cm-1). If a sample is suspect, it is not advisable to purify it because it is likely to deteriorate further as “dry box” conditions are necessary. Either a new sample is purchased or one is freshly prepared from folic acid. It has the above pKa values. [Hafeti et al. Biochemical Preparations 7 89 1960, UV: Mathews & Huennekens J Biol Chem 235 3304 1960, Osborn & Huennekens J Biol Chem 233 969 1958, O'Dell et al. J Am Chem Soc 69 250 1947, Blakley Biochem J 6 5 331 1957, Asahi Yakugaku Zasshi (J Pharm Soc Jpn) 79 1548 1959, Beilstein 26 III/IV 3879.]
L-Tetrahydrofolic Acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21587 | 55 |
| Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14332 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19936 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29792 | 58 |
| Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 | sale04@alfachem.cn | China | 9542 | 58 |
| Creative Enzymes | 1-516-855-7709 | info@creative-enzymes.com | United States | 8748 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32466 | 58 |
| Hubei Ipure Biology Co., Ltd | +8613367258412 | ada@ipurechemical.com | China | 10236 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
View Lastest Price from L-Tetrahydrofolic Acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-05-11 | Tetrahydrofolic acid
135-16-0
|
$30.00-40.00 | 99.78% | 10g | TargetMol Chemicals Inc. | ||
 |
2025-11-18 | L-Tetrahydrofolic Acid USP/EP/BP
135-16-0
|
$1.10 | 1g | 99.9% | 100 Tons min | Dideu Industries Group Limited | |
 |
2020-02-02 | L-Tetrahydrofolic Acid
135-16-0
|
$1.00 | 1KG | 98% HPLC | 10 tons | Career Henan Chemical Co |
-
- Tetrahydrofolic acid
135-16-0
- $30.00-40.00
- 99.78%
- TargetMol Chemicals Inc.
-
- L-Tetrahydrofolic Acid USP/EP/BP
135-16-0
- $1.10
- 99.9%
- Dideu Industries Group Limited
-
- L-Tetrahydrofolic Acid
135-16-0
- $1.00
- 98% HPLC
- Career Henan Chemical Co
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