Urease
- CAS No.
- 9002-13-5
- Chemical Name:
- Urease
- Synonyms
- UREA AMIDOHYDROLASE;URH;UREASE;3.5.1.5;EC 3.5.1.5;EC 6.3.4.6;ensiformis;Urease,jack;Urease Bean;Urease（URH）
- CBNumber:
- CB6263726
- Molecular Formula:
- N/A
- Molecular Weight:
- 0
- MDL Number:
- MFCD00070858
- MOL File:
- Mol file
- MSDS File:
- SDS
- TDS File:
- TDS
| Density | 1.10-1.30g/cm3 at 20°C |
|---|---|
| bulk density | 410kg/m3 |
| storage temp. | 2-8°C |
| solubility | 0.05 M Tris-HCl/0.001 M EDTA, pH 8.0: 5mg/mL |
| form | powder |
| color | yellow |
| PH | 6.0-7.0 (20°C, 5g/L in H2O, slurry) |
| biological source | Canavalia ensiformis |
| Water Solubility | It is slightly soluble in water. |
| Merck | 14,9870 |
| Specific Activity | 50,000-100,000units/g solid |
| Cosmetics Ingredients Functions | VISCOSITY CONTROLLING |
| FDA 21 CFR | 184.1924 |
| EWG's Food Scores | 1 |
| EPA Substance Registry System | Urease (9002-13-5) |
| UNSPSC Code | 12352204 |
| NACRES | NA.54 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H315-H319-H334-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P302+P352-P304+P340+P312-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 36/37/38-42 | |||||||||
| Safety Statements | 22-24-26-36/37-45-36-23 | |||||||||
| WGK Germany | 1 | |||||||||
| RTECS | YU1700000 | |||||||||
| F | 10-21 | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 35079090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Resp. Sens. 1 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
Urease price More Price(36)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | U4002 | Urease from Canavalia ensiformis (Jack bean) Type IX, powder, 50,000-100,000?units/g solid | 9002-13-5 | 20000units | $102 | 2026-04-30 | Buy |
| Sigma-Aldrich | U4002 | Urease from Canavalia ensiformis (Jack bean) Type IX, powder, 50,000-100,000?units/g solid | 9002-13-5 | 100000units | $310 | 2026-04-30 | Buy |
| Sigma-Aldrich | U7752 | Urease from Canavalia ensiformis (Jack bean) | 9002-13-5 | 1vial | $118 | 2026-04-30 | Buy |
| Sigma-Aldrich | U4002 | Urease from Canavalia ensiformis (Jack bean) Type IX, powder, 50,000-100,000?units/g solid | 9002-13-5 | 500000units | $1120 | 2026-04-30 | Buy |
| Sigma-Aldrich | U4002 | Urease from Canavalia ensiformis (Jack bean) Type IX, powder, 50,000-100,000?units/g solid | 9002-13-5 | 1000000units | $1930 | 2026-04-30 | Buy |
Urease Chemical Properties, Uses, Production
Description
Urease is found in the natural environment (water and soil) and in human body, where its occurrence is connected with protein degradation. It is an enzyme and is capable of urea hydrolysis: one molecule of ammonia and one molecule of carbamate appear in the first step, carbamate spontaneously converts into the second ammonia molecule and carbonic acid in a water solution, and ammonia is protonated. This urea hydrolysis results in pH increase. Urease and ammonia, generated during urea hydrolysis, may be toxic for human tissue and probably have role in long-lasting diseases, like atherosclerosis, urinary tract infections, or rheumatoid arthritis.
Urease can be used to analyze urea concentration in blood, urine, alcoholic beverages, natural water and environmental wastewaters; to analyze heavy metal content in natural waters, wastewaters and soil; to determine creatinine, arginine and IgG; to remove urea from artificial kidney dialyzates, alcohol beverages and fertilizer wastewaters; to control or shift pH for multi-enzyme reaction system; to hydrolyze urea as sources of ammonia or carbon dioxide in special cases, and for the wastewater reclamation for life support systems in space.
References
[1] Iwona Konieczna, Paulina ?arnowiec, Marek Kwinkowski, Beata Kolesińska, Justyna Fr?czyk, Zbigniew Kamiński, Wies?aw Kaca (2012) Bacterial Urease and its Role in Long-Lasting Human Diseases, Curr Protein Petp Sci., 13, 789-806
[2] Yingjie Qin, Joaquim M. S. Cabral (2002) Review: Properties and Applications of Urease, Biocatalysis and Biotransformation, 20, 1-14
Chemical Properties
powder
Uses
Urease from Canavalia ensiformis may be used for urea determination of various samples, such as legumes. It may be useful for the detection of pathogens as well as heavy-metal ions.
Uses
Clinical reagent in determination of urea in body fluid.
Uses
Urease from Canavalia ensiformis may be used for urea determination of various samples, such as legumes . It may be useful for the detection of pathogens as well as heavy-metal ions.
General Description
Subunit molecular weight: ~90,770
Composed of six subunits with total molecular weight: ~544,620
Agricultural Uses
Urease, an enzyme, converts urea into ammonium
carbonate [(NH4)2CO3] that releases ammonia. Thus, the
enzyme activates the hydrolysis of urea. When the
release occurs on or near the soil surface, ammonia is lost
to the air; if it occurs near the seeds, they fail to
germinate, or it proves to be toxic to the roots of young
saplings. Crops can get affected by a high concentration
of ammonia. Soybean, jack beans and a number of fungi
are sources of urease. Its isoelectric point is pH 5.5.
Urease enzyme catalyzes the hydrolysis of urea which
occurs readily in the soils. Large numbers of bacteria,
fungi and actinomycetes in soils possess urease. A small
group of bacteria, known as urea bacteria, have an
exceptional ability to decompose urea. Activity increases
in proportion with the size of the soil microbial
population and the organic matter content. The presence
of relatively fresh plant residues often results in abundant
supplies of urease. The greatest activity of urease is
reported to occur in the rhizosphere, where microbial
activity is high and where it can be excreted from the
plant roots.
Although warm temperature (up to 37°C) favors
urease activity, the hydrolysis of urea occurs at
significant rates at temperatures down to 2°C. The effects
of soil moisture levels on urease activity are generally
small in comparison to the influence of the pH and
temperature. Free ammonia inhibits the enzymatic action
of urease.
Biochem/physiol Actions
Urease catalyzes the hydrolysis of urea into carbon dioxide and ammonia. Urease is involved in nitrogen metabolism and urea degradation. Urease from Canavalia ensiformis binds 2 nickel ions per subunit .
Description
The mutant Urease from microorganism source, showing shifted substrate affinity to urea. It was designed wildtype coding gene from microorganism. The subunit structure is very similar to well known microbial urease. Please refer to published literature such as JBC 262, 5963-67 (1987). It is composed of multi-subunits and shows a bit complex protein structure (alpha 2 Beta 4 Gamma 4) as compared to plant urease rUrease is genetically designed unique mutant having shifted high Km to urea, which is suited material to kinetic urea assay with wide measurable range. The enzyme comprises of three different subunits to make complete fully active form, 60.3 kD a subunit, 11.7 kD b subunit and 11.1 kD g subunit respectively.
Source
Escherichia Coli
Urease Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nanjing Dulai Biotechnology Co., Ltd. | 025-84699383-8003;025-846993838003-8003 18013301590 | njduly@126.com | China | 3293 | 55 |
| Shanghai Baoman Biotechnology Co., Ltd. | 021-62130998 | baomanbio@163.com | China | 202 | 55 |
| Shanghai Uteam Biotechnology Co., Ltd. | 021-36031160 13311776681 | 3338195766@QQ.com | China | 5091 | 55 |
| Shanghai Biological Technology Development Co., Ltd. | 021-69955236-807 13918189704 | chinaruji@chinaruji.com | China | 5093 | 55 |
| BIOISCO(Lianyungang, Jiangsu) Biotechnology Co., Ltd | 18082049515 | 2757382053@qq.com | China | 2995 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Beijing HwrkChemical Technology Co., Ltd | 89508211 18501085097 | sales.bj@hwrkchemical.com | China | 9409 | 55 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
View Latest Price from Urease manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-23 | Urease
9002-13-5
|
1g | 98.0% | 1kg/month | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2026-09-02 | Urease
9002-13-5
|
$5.00-8.00 | 1KG | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2025-12-24 | Urease
9002-13-5
|
1KG | 99.0% | 1000Tons | Shaanxi Dideu Medichem Co. Ltd |
