Ethanol, 2-(2-hydroxyethoxy)-, 1-(4-Methylbenzenesulfonate)
- CAS No.
- 118591-58-5
- Chemical Name:
- Ethanol, 2-(2-hydroxyethoxy)-, 1-(4-Methylbenzenesulfonate)
- Synonyms
- 2-(2-Hydroxyethoxy)ethyl 4-methylbenzenesulfonate;HO-PEG2-OTS;Tos-PEG2-OH;peg2-tos;OH-PEG2-Tos;TsO-PEG2-OH;OH-PEG2-OTs;CAS_118591-58-5;Tos-PEG2-alcohol;Diethylene glycol p-toluenesulfonate
- CBNumber:
- CB62648165
- Molecular Formula:
- C11H16O5S
- Molecular Weight:
- 260.30674
- MDL Number:
- MFCD22574797
- MOL File:
- 118591-58-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 2-(2-Hydroxyethoxy)ethyl 4-methylbenzenesulfonate | ANV00334 | 1G | $529 |
| Tos-PEG2-OH ≥95% | CS-0133776 | 100mg | $18 |
| Tos-PEG2-OH ≥95% | CS-0133776 | 250mg | $28 |
| Tos-PEG2-OH ≥95% | CS-0133776 | 500mg | $55 |
| Tos-PEG2-OH ≥95% | CS-0133776 | 1g | $101 |
| More product size | |||
| Boiling point | 427.4±30.0 °C(Predicted) |
|---|---|
| Density | 1.256±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| pka | 14.32±0.10(Predicted) |
| form | Liquid |
| color | Colorless to light yellow |
| InChI | InChI=1S/C11H16O5S/c1-10-2-4-11(5-3-10)17(13,14)16-9-8-15-7-6-12/h2-5,12H,6-9H2,1H3 |
| InChIKey | KLDLLRZCWYKJBD-UHFFFAOYSA-N |
| SMILES | C(OS(C1=CC=C(C)C=C1)(=O)=O)COCCO |
| UNSPSC Code | 12352200 |
| NACRES | NA.21 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P280-P305+P351+P338 |
| WGK Germany | WGK 3 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Acute Tox. 4 Oral |
Ethanol, 2-(2-hydroxyethoxy)-, 1-(4-Methylbenzenesulfonate) price More Price(39)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | ANV00334 | 2-(2-Hydroxyethoxy)ethyl 4-methylbenzenesulfonate | 118591-58-5 | 1G | $529 | 2026-04-30 | Buy |
| ChemScene | CS-0133776 | Tos-PEG2-OH ≥95% | 118591-58-5 | 100mg | $18 | 2026-06-04 | Buy |
| ChemScene | CS-0133776 | Tos-PEG2-OH ≥95% | 118591-58-5 | 250mg | $28 | 2026-06-04 | Buy |
| ChemScene | CS-0133776 | Tos-PEG2-OH ≥95% | 118591-58-5 | 500mg | $55 | 2026-06-04 | Buy |
| ChemScene | CS-0133776 | Tos-PEG2-OH ≥95% | 118591-58-5 | 1g | $101 | 2026-06-04 | Buy |
Ethanol, 2-(2-hydroxyethoxy)-, 1-(4-Methylbenzenesulfonate) Chemical Properties,Uses,Production
Uses
Tos-PEG2-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Synthesis
98-59-9
111-46-6
118591-58-5
The general procedure for the synthesis of 2-(2-hydroxyethoxy)ethyl 4-methylbenzenesulfonate from p-toluenesulfonyl chloride and diethylene glycol was as follows: first, the diethylene glycol was protected with a monohydroxy group. This was done as follows: in a dichloromethane solvent, potassium iodide (0.2 eq.) was added as a catalyst, followed by freshly prepared silver oxide (1.5 eq.) and p-toluenesulfonyl chloride (1.1 eq.). The reaction mixture was stirred at room temperature for 8-10 h. Upon completion of the reaction, mono-p-toluenesulfonyl-protected diethylene glycol was obtained in 97-99% yield. This step provides a selectively protected intermediate for the subsequent reaction with aconitic acid.
IC 50
PEGs
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
Ethanol, 2-(2-hydroxyethoxy)-, 1-(4-Methylbenzenesulfonate) Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32997 | 60 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 | contact@trustwe.com | China | 5742 | 58 |
| Wuhan Borenpharm Co., Ltd | 027-65563561 18717150066 | 3207347307@qq.com | CHINA | 1238 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +86-13203830695 | laboratory@coreychem.com | China | 30203 | 58 |
| XIAMEN SINOPEG BIOTECH CO., LTD. | +86-0592-7761068 15616186207 | changaiwei@sinopeg.com | China | 1133 | 58 |
| sgtlifesciences pvt ltd | +91-8790379245 | dj@sgtlifesciences.com | China | 12351 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418684 +86-18949823763 | sales@tnjchem.com | China | 25333 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 +8619957148339 | market18@leapchem.com | China | 24569 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 38999 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +86-18327326525 | masar@topule.com | China | 8433 | 58 |
View Lastest Price from Ethanol, 2-(2-hydroxyethoxy)-, 1-(4-Methylbenzenesulfonate) manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-24 | OH-PEG2-Tos
118591-58-5
|
1g | 98% | 1g/bottle, 10g/bottle, 100g/bottle | XIAMEN SINOPEG BIOTECH CO., LTD. | ||
 |
2026-07-14 | Tos-PEG2-alcohol
118591-58-5
|
1kg | 98% | 1000kg | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2026-05-11 | Tos-PEG2-OH
118591-58-5
|
10g | TargetMol Chemicals Inc. |
-
- OH-PEG2-Tos
118591-58-5
- 98%
- XIAMEN SINOPEG BIOTECH CO., LTD.
-
- Tos-PEG2-alcohol
118591-58-5
- 98%
- Shaanxi Dideu New Materials Co. Ltd
-
- Tos-PEG2-OH
118591-58-5
- $0.00
- TargetMol Chemicals Inc.
