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BOC-D-ALPHA-T-BUTYLGLYCINE

BOC-D-ALPHA-T-BUTYLGLYCINE structure

CAS No.: 124655-17-0

Chemical Name:: BOC-D-ALPHA-T-BUTYLGLYCINE

Synonyms: Boc-D-Tle;Boc-D-t-Leu;BOC-D-TLE-OH;Boc-D-Tle-0H;BOC-TBU-D-GLY-OH;BOC-D-(TBU)GLY-OH;BOC-D-TERT-LEUCINE;BOC-D- Tert-Leu-OH;N-BOC-D-TERT-LEUCINE;BOC-D-T-BUTYLGLYCINE

CBNumber:: CB6271402

Molecular Formula:: C11H21NO4

Molecular Weight:: 231.29

MDL Number:: MFCD00065575

MOL File:: 124655-17-0.mol

Last updated:2025-07-24 18:13:43

Product description	Number	Pack Size	Price
N-(tert-Butoxycarbonyl)-D-tert-leucine >98.0%(HPLC)(T)	B3995	1g	$46
N-(tert-Butoxycarbonyl)-D-tert-leucine >98.0%(HPLC)(T)	B3995	5g	$183
N-Boc-D-tert-leucine	B667830	2.5g	$385
N-Boc-D-tert-Leucine 95+% ee	AS35415	25g	$453
Boc-D-tert-leucine	4158-1-R0	1g	$336
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BOC-D-ALPHA-T-BUTYLGLYCINE Properties

Melting point	118-121°C
Boiling point	350.0±25.0 °C(Predicted)
Density	1.063±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
solubility	slightly sol. in Methanol
pka	4.03±0.10(Predicted)
form	Solid
color	White to Almost white
optical activity	Consistent with structure
InChI	InChI=1S/C11H21NO4/c1-10(2,3)7(8(13)14)12-9(15)16-11(4,5)6/h7H,1-6H3,(H,12,15)(H,13,14)/t7-/m0/s1
InChIKey	LRFZIPCTFBPFLX-ZETCQYMHSA-N
SMILES	C(O)(=O)[C@@H](C(C)(C)C)NC(OC(C)(C)C)=O
CAS DataBase Reference	124655-17-0(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319

Precautionary statements

P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

HazardClass

IRRITANT

HS Code

2924190090

NFPA 704

	1
0		0

BOC-D-ALPHA-T-BUTYLGLYCINE price More Price(47)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	B3995	N-(tert-Butoxycarbonyl)-D-tert-leucine >98.0%(HPLC)(T)	124655-17-0	1g	$46	2025-07-31	Buy
TCI Chemical	B3995	N-(tert-Butoxycarbonyl)-D-tert-leucine >98.0%(HPLC)(T)	124655-17-0	5g	$183	2025-07-31	Buy
TRC	B667830	N-Boc-D-tert-leucine	124655-17-0	2.5g	$385	2021-12-16	Buy
Activate Scientific	AS35415	N-Boc-D-tert-Leucine 95+% ee	124655-17-0	25g	$453	2021-12-16	Buy
SynQuest Laboratories	4158-1-R0	Boc-D-tert-leucine	124655-17-0	1g	$336	2021-12-16	Buy

Product number	Packaging	Price	Buy
B3995	1g	$46	Buy
B3995	5g	$183	Buy
B667830	2.5g	$385	Buy
AS35415	25g	$453	Buy
4158-1-R0	1g	$336	Buy

BOC-D-ALPHA-T-BUTYLGLYCINE Chemical Properties,Uses,Production

Chemical Properties

White powder

Uses

N-Boc-D-tert-leucine is a protected form of D-tert-leucine, and is used in the synthesis of primary amino acid derivatives (e.g. Desacetyl Desmethyl Lacosamide [D288325]) that possess anticonvulsant and neuropathic pain protection properties.

Synthesis

26782-71-8

24424-99-5

124655-17-0

General procedure for the synthesis of tert-butoxycarbonyl-D-tert-leucine from D-tert-leucine and di-tert-butyl dicarbonate: 3-methyl-D-valine (900 mg, 6.86 mmol) was dissolved in a mixture of 7 mL of a 1 M aqueous sodium hydroxide solution and 7 mL of methanol at 0°C, followed by the addition of di-tert-butyl dicarbonate (Boc-anhydride, 1.797 g, 8.23 mmol). The reaction mixture was gradually warmed to room temperature and stirred continuously overnight. Upon completion of the reaction, most of the methanol was removed by evaporation, and the reaction solution was acidified to pH 2 with 1 M aqueous HCl, followed by three extractions with ethyl acetate (3 × 20 mL). The organic phases were combined and washed twice with brine (2 × 5 mL). Finally, the solvent was removed by evaporation to afford tert-butoxycarbonyl-D-tert-leucine as a white solid in 83% yield (1.36 g). The product was characterized by NMR (400 MHz, DMSO-d6): δ 12.44 (1H, s), 6.82 (1H, d), 3.76 (1H, d), 1.38 (9H, s); UPLC analysis showed a retention time of 0.64 min and a molecular ion peak of 232 [M + H]+.

References

[1] Patent: WO2011/69951, 2011, A1. Location in patent: Page/Page column 77
[2] Journal of Medicinal Chemistry, 2008, vol. 51, # 15, p. 4620 - 4631
[3] Journal of Medicinal Chemistry, 2011, vol. 54, # 13, p. 4815 - 4830
[4] Patent: WO2012/76877, 2012, A1. Location in patent: Page/Page column 97
[5] Patent: US2013/267510, 2013, A1. Location in patent: Paragraph 0708-0710

BOC-D-ALPHA-T-BUTYLGLYCINE Preparation Products And Raw materials

Raw materials

D-tert-Butylglycine Di-tert-butyl dicarbonate Water Sodium hydroxide Methanol

Preparation Products

Boc-D-tert-Leucinol

BOC-D-ALPHA-T-BUTYLGLYCINE Suppliers

Global( 239)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	+8615350571055	Sibel@chuanghaibio.com	China	8772	58
Sichuan Zhuoyu Yantang Technology Co., Ltd.	+8613288715578	sales@sichuanzyyt.com	China	12247	58
Sichuan HongRi Pharma-Tech Co.,Ltd	+8617390183901	cynthia@enlaibio.com	China	1100	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29734	60
Taizhou Tianhong Biochemistry Technology Co., Ltd.	0523-86132544	sales@thbiochem.com	CHINA	305	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21620	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29852	58
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	8497	58
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58

Supplier	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	58
Sichuan Zhuoyu Yantang Technology Co., Ltd.	58
Sichuan HongRi Pharma-Tech Co.,Ltd	58
Capot Chemical Co.,Ltd.	60
Taizhou Tianhong Biochemistry Technology Co., Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Jinan Carbotang Biotech Co.,Ltd.	58
Accela ChemBio Inc.	58

View Lastest Price from BOC-D-ALPHA-T-BUTYLGLYCINE manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-10-17	Boc-D-Tle-OH 124655-17-0	US $0.00-0.00 / kg	1kg	98%	1T	Sichuan HongRi Pharma-Tech Co.,Ltd
2025-10-17	BOC-D-ALPHA-T-BUTYLGLYCINE 124655-17-0	US $10.00 / KG	1KG	99%	10 mt	Hebei Chuanghai Biotechnology Co., Ltd
2025-08-08	BOC-D-ALPHA-T-BUTYLGLYCINE 124655-17-0	US $0.00 / kg	1kg	99%	1000tons	Sichuan Zhuoyu Yantang Technology Co., Ltd.

Boc-D-Tle-OH
124655-17-0
US $0.00-0.00 / kg
98%
Sichuan HongRi Pharma-Tech Co.,Ltd

BOC-D-ALPHA-T-BUTYLGLYCINE
124655-17-0
US $10.00 / KG
99%
Hebei Chuanghai Biotechnology Co., Ltd

BOC-D-ALPHA-T-BUTYLGLYCINE
124655-17-0
US $0.00 / kg
99%
Sichuan Zhuoyu Yantang Technology Co., Ltd.

BOC-D-ALPHA-T-BUTYLGLYCINE Spectrum

BOC-D-ALPHA-T-BUTYLGLYCINE(124655-17-0)¹HNMR

124655-17-0(BOC-D-ALPHA-T-BUTYLGLYCINE)Related Search:

N-Boc-D-Valino BOC-D-THR-OH N-Boc-L-valine Boc-D-Thr-Obzl Boc-beta-alanine

N-(tert-Butoxycarbonyl)-L-alanine BOC-BETA-TBU-D-ALA-OH 4-(Aminocarbonyl)-N-[(1,1-dimethylethoxy)carbonyl]-2,6-dimethyl-L-phenylalanine (BOC-AMINOOXY)ACETIC ACID TERT-BUTOXY ACETIC ACID

Boc-L-aspartic acid 4-tert-butyl ester Boc-D-aspartic acid 4-benzyl ester TERT-BUTYL N-ALLYLCARBAMATE BOC-ALA-GLY-OH BOC-HYP-OL

N-Boc-L-Phenylalaninol N-Boc-exo-3-aminotropane BOC-D-Methionine

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(R)-2-((tert-Butoxycarbonyl)aMino)-3,3-diMethylbutanoic acid Boc-D-t-Leu N-alpha-t-Butyloxycarbonyl-D-t-leucine, N-alpha-t-Butyloxycarbonyl-D-t-butylglycine N-BOC-D-TERT-LEUCINE (R)-2-(tert-butoxycarbonyl)-3,3-dimethylbutanoic a BOC-TBU-D-GLY-OH BOC-D-(TBU)GLY-OH BOC-D-T-BUTYLGLYCINE BOC-D-TERT-LEUCINE BOC-D-TLE-OH BOC-D-ALPHA-T-BUTYLGLYCINE BOC-D-ALPHA-T-BUTYL-GLY-OH N-ALPHA-T-BOC-D-ALPHA-T-BUTYLGLYCINE N-ALPHA-T-BOC-D-T-LEUCINE N-ALPHA-T-BUTOXYCARBONYL-D-L-BUTYLGLYCINE N-ALPHA-T-BUTOXYCARBONYL-D-T-BUTYLGLYCINE N-ALPHA-T-BUTOXYCARBONYL-D-T-LEUCINE (R)-N-ALPHA-T-BUTOXYCARBONYL-2-AMINO-3,3-DIMETHYL-BUTYRIC ACID (R)-N-(TERT-BUTOXYCARBONYL)-TERT-LEUCINE N-(tert-Butoxycarbonyl)-D-tert-leucine N-(tert-Butoxycarbonyl)-D-tert-leucine D-Valine, N-[(1,1-dimethylethoxy)carbonyl]-3-methyl- (R)-N-Boc-2-amino-3,3-dimethylbutyric acid Boc-D-α-tert-butylglycine≥ 98% (HPLC) Boc-D-α-tert-butyl-Gly-OH N-Boc-D-tert-leucine,99%e.e. 2-{[(tert-Butoxycarbonyl)amino]methyl}-3,3-dimethylbutanoic acid (Tert-Butoxy)Carbonyl D-Tle-OH (2R)-2-{[(tert-butoxy)carbonyl]amino}-3,3-dimethylbutanoic acid Boc-D-Tle (2R)-3,3-dimethyl-2-[[(2-methylpropan-2-yl)oxy-oxomethyl]amino]butanoic acid N-(tert-Butoxycarbonyl)-D-tert-leucine > (2R)-3,3-dimethyl-2-[(2-methylpropan-2-yl)oxycarbonylamino]butanoic acid N-Boc-D-tert-leucine,95% (2R)-3,3-dimethyl-2-[(2-methylpropan-2-yl)oxycarbonylamino]butanoicaci (R)-2-(Boc-amino)-3,3-dimethylbutyric Acid (R)-2-(tert-Butoxycarbonylamino)-3,3-dimethylbutyric Acid BOC-D-ALPHA-T-BUTYLGLYCINE USP/EP/BP Boc-D-α-tert-butylglycine 124655-17-0 BOC-D-ALPHA-T-BUTYLGLYCINE (2R)-3,3-dimethyl-2-[(2-methylpropan-2-yl)oxycarbonylamin BOC-D-ALPHA-T-BUTYLGLYCINE Powder USP Standard BOC-D- Tert-Leu-OH 2,4-Dichlorobenzyl Alcohol Impurity 9 Boc-D-Tle-0H 124655-17-0 C11H21NO4 Amino Acids CHIRAL COMPOUNDS Amino Acids & Deriv. CHIRAL CHEMICALS Peptide