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2-chloro-5-iodo-4-methoxypyridine

2-chloro-5-iodo-4-methoxypyridine Structure
2-chloro-5-iodo-4-methoxypyridine structure
CAS No.
1226878-98-3
Chemical Name:
2-chloro-5-iodo-4-methoxypyridine
Synonyms
2-chloro-5-iodo-4-methoxypyridin;2-chloro-5-iodo-4-methoxypyridine;Pyridine, 2-chloro-5-iodo-4-methoxy-
CBNumber:
CB62738196
Molecular Formula:
C6H5ClINO
Molecular Weight:
269.47
MDL Number:
MFCD18415711
MOL File:
1226878-98-3.mol
Last updated:2025-08-08 17:45:00
Product description Number Pack Size Price
2-Chloro-5-iodo-4-methoxypyridine 97% AS116943 1g $195
2-Chloro-5-iodo-4-methoxypyridine 97% AS116943 5g $539
2-Chloro-5-iodo-4-methoxypyridine 97% C42674 100mg $63
2-Chloro-5-iodo-4-methoxypyridine 97% C42674 250mg $70
2-Chloro-5-iodo-4-methoxypyridine 97% C42674 1g $300
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2-chloro-5-iodo-4-methoxypyridine Properties

Boiling point 301.8±42.0 °C(Predicted)
Density 1.915±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2–8 °C
pka 0.11±0.10(Predicted)
Appearance White to light yellow Solid

2-chloro-5-iodo-4-methoxypyridine price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Activate Scientific AS116943 2-Chloro-5-iodo-4-methoxypyridine 97% 1226878-98-3 1g $195 2026-06-04 Buy
Activate Scientific AS116943 2-Chloro-5-iodo-4-methoxypyridine 97% 1226878-98-3 5g $539 2026-06-04 Buy
Synthonix C42674 2-Chloro-5-iodo-4-methoxypyridine 97% 1226878-98-3 100mg $63 2026-05-06 Buy
Synthonix C42674 2-Chloro-5-iodo-4-methoxypyridine 97% 1226878-98-3 250mg $70 2026-05-06 Buy
Synthonix C42674 2-Chloro-5-iodo-4-methoxypyridine 97% 1226878-98-3 1g $300 2026-05-06 Buy
Product number Packaging Price Buy
AS116943 1g $195 Buy
AS116943 5g $539 Buy
C42674 100mg $63 Buy
C42674 250mg $70 Buy
C42674 1g $300 Buy

2-chloro-5-iodo-4-methoxypyridine Chemical Properties,Uses,Production

Synthesis

2-Chloro-4-methoxypyridine

17228-69-2

2-chloro-5-iodo-4-methoxypyridine

1226878-98-3

At room temperature, 2-chloro-4-methoxypyridine (0.5 g, 3.48 mmol) was dissolved in sulfuric acid (2.5 mL), followed by batchwise addition of N-iodosuccinimide (0.825 g, 3.48 mmol). The reaction mixture was stirred at 55 °C for 2 hours. After completion of the reaction, the mixture was slowly poured into ice water (10 mL) and 8 M NaOH solution (20 mL) was added dropwise, at which time the color of the solution changed from dark brown to light yellow. The aqueous layer was extracted with water (2 x 20 mL) and dichloromethane (CH2Cl2). The organic layers were combined and washed with brine (10 mL), followed by adsorption of the organic phase onto silica gel by vacuum concentration. Purification by fast column chromatography using a solvent mixture of 25% ethyl acetate (EtOAc) and cyclohexane (c-Hex) as eluent resulted in 2-chloro-5-iodo-4-methoxypyridine as a white crystalline solid (0.169 g, 0.760 mmol, 22% yield). The product was characterized by 1H NMR (500 MHz, d6-DMSO): δ 8.52 (s, 1H), 7.19 (s, 1H), 3.96 (s, 3H); LC-MS (LCT, 4 min) retention time (Rt) = 2.56 min; mass spectrometry (ESI) m/z 270 ([M+H]+).

References

[1] Journal of Medicinal Chemistry, 2012, vol. 55, # 22, p. 10229 - 10240
[2] Patent: WO2013/68755, 2013, A1. Location in patent: Page/Page column 70; 71
[3] Patent: WO2017/69980, 2017, A1. Location in patent: Paragraph 00502; 00503

2-chloro-5-iodo-4-methoxypyridine Preparation Products And Raw materials

Raw materials

2-Chloro-4-methoxypyridine

Preparation Products

2-chloro-5-iodo-4-methoxypyridine Suppliers

Global( 41)Suppliers
Supplier Tel Email Country ProdList Advantage
CONIER CHEM AND PHARMA LIMITED 		sales@conier.com China 49906 58
HANGZHOU LEAP CHEM CO., LTD. 		+86-571-87711850 +8619957148339 market18@leapchem.com China 24569 58
HANGZHOU LEAP CHEM CO., LTD. 		+86-571-87711850 +86-15355479329 market18@leapchem.com China 43303 58
ANHUI BYERSEN BIOTECH CO. LTD 		+86-15385096007 +86-17755058861 amy@byersenchemical.com China 10000 58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. 025-66028182 17714375163 yftan@aikonchem.com China 16674 50
SuZhou ShiYa Biopharmaceuticals, Inc. 0512-0512-52358471 17715136450 sales@shiyabiopharm.com China 9814 58
Henan Alfachem Co.,Ltd. 0371-55051623 18137891487 3983243027@qq.com China 9947 58
Accela ChemBio Co.,Ltd. 021-50795510 4000665055 marketing@accelachem.com China 10455 58
Birdo (Shanghai) Medical Technology Co., Ltd. 021-58099077-8041 18601625411 sales@birdotech.com China 9393 58
Taizhou Nanfeng Pharmaceutical Research Institute nanfengpharma@126.co 18616377689 nanfengpharma@126.com China 20008 58
Supplier Advantage
CONIER CHEM AND PHARMA LIMITED 		58
HANGZHOU LEAP CHEM CO., LTD. 		58
HANGZHOU LEAP CHEM CO., LTD. 		58
ANHUI BYERSEN BIOTECH CO. LTD 		58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. 50
SuZhou ShiYa Biopharmaceuticals, Inc. 58
Henan Alfachem Co.,Ltd. 58
Accela ChemBio Co.,Ltd. 58
Birdo (Shanghai) Medical Technology Co., Ltd. 58
Taizhou Nanfeng Pharmaceutical Research Institute 58

View Lastest Price from 2-chloro-5-iodo-4-methoxypyridine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-chloro-5-iodo-4-methoxypyridine pictures 2026-08-16 2-chloro-5-iodo-4-methoxypyridine
1226878-98-3
 $70.00-700.00 10kg 0.99 20tons Zibo Hangyu Biotechnology Development Co., Ltd

2-chloro-5-iodo-4-methoxypyridine Spectrum

2-chloro-5-iodo-4-methoxypyridine(1226878-98-3)1HNMR
2-chloro-5-iodo-4-methoxypyridine Pyridine, 2-chloro-5-iodo-4-methoxy- 2-chloro-5-iodo-4-methoxypyridin 1226878-98-3