Clobetasol propionate
- CAS No.
- 25122-46-7
- Chemical Name:
- Clobetasol propionate
- Synonyms
- CLOBETASOLE PROPIONATE;CLOBETASOL-17-PROPIONATE;17-propionate;Olux;Clobex;Temovate;Dermovate;Clobetazole propionate;21-Chloro-9-fluoro-11b,17-dihydroxy-16b-methylpregna-1,4-diene-3,20-dione 17-propionate;Psorex
- CBNumber:
- CB6274337
- Molecular Formula:
- C25H32ClFO5
- Molecular Weight:
- 466.97
- MDL Number:
- MFCD00058499
- MOL File:
- 25122-46-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 195.5-1970C |
|---|---|
| alpha | D +103.8° (c = 1.04 in dioxane) |
| Boiling point | 569.0±50.0 °C(Predicted) |
| Density | 1.1653 (estimate) |
| storage temp. | Keep in dark place,Sealed in dry,2-8°C |
| solubility | Practically insoluble in water, freely soluble in acetone, sparingly soluble in ethanol (96 per cent). |
| pka | 12.88±0.70(Predicted) |
| form | Solid |
| color | White to off-white |
| Major Application |
forensics and toxicology veterinary |
| InChIKey | CBGUOGMQLZIXBE-XGQKBEPLSA-N |
| SMILES | O([C@@]1([C@H](C[C@@]2([H])[C@]3([H])CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]12C)C)C(=O)CCl)C(=O)CC |&1:1,2,4,6,16,18,20,23,r| |
| CAS DataBase Reference | 25122-46-7(CAS DataBase Reference) |
| FDA UNII | 779619577M |
| Proposition 65 List | Clobetasol Propionate |
| NCI Drug Dictionary | clobetasol propionate |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H360Df-H373-H413 | |||||||||
| Precautionary statements | P201-P273-P308+P313 | |||||||||
| target organs | Adrenal gland,Immune system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi,T | |||||||||
| Risk Statements | 36/37/38-62-53-48/20/21-61 | |||||||||
| Safety Statements | 26-36-45-36/37-53 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | TU3725000 | |||||||||
| HS Code | 29372290 | |||||||||
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
|||||||||
| Hazard Classifications | Aquatic Chronic 4 Repr. 1B STOT RE 2 |
|||||||||
| NFPA 704 |
|
Clobetasol propionate price More Price(56)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | Y0002164 | Clobetasol propionate for peak identification CRS, European Pharmacopoeia (EP) Reference Standard | 25122-46-7 | 2 mg | $170 | 2026-04-30 | Buy |
| Sigma-Aldrich | Y0000559 | Clobetasol propionate European Pharmacopoeia (EP) Reference Standard | 25122-46-7 | 55 mg | $254 | 2026-04-30 | Buy |
| Sigma-Aldrich | C8037 | Clobetasol propionate analytical standard | 25122-46-7 | 1g | $388 | 2026-04-30 | Buy |
| Sigma-Aldrich | BP521 | Clobetasol propionate British Pharmacopoeia (BP) Reference Standard | 25122-46-7 | 100mg | $258 | 2026-04-30 | Buy |
| Sigma-Aldrich | 1138405 | Clobetasol propionate United States Pharmacopeia (USP) Reference Standard | 25122-46-7 | 200mg | $455 | 2026-04-30 | Buy |
Clobetasol propionate Chemical Properties,Uses,Production
Mechanism of Action
Clobetasol Propionate is the propionate salt form of clobetasol, a topical synthetic corticosteroid with anti-inflammatory, anti-pruritic, and vasoconstrictive properties. Clobetasol propionate exerts its effect by binding to cytoplasmic glucocorticoid receptors and subsequently activates glucocorticoid receptor mediated gene expression. This results in the synthesis of certain anti-inflammatory proteins, while inhibiting the synthesis of certain inflammatory mediators. Specifically, clobetasol propionate appears to induce phospholipase A2 inhibitory proteins, thereby controlling the release of the inflammatory precursor arachidonic acid from membrane phospholipids by phospholipase A2.
Indications
Clobetasol propionate is the 17-O-propionate ester of clobetasol and it derives from a clobetasol and a propionic acid. A potent corticosteroid, it is used to treat various skin disorders, including exzema and psoriasis.
Clobetasol propionate was patented in 1968 and came into medical use in 1978. It is available as a generic medication. Clobetasol propionate is used for the treatment of various skin disorders including eczema, herpes labialis, psoriasis, and lichen sclerosus. It is also used to treat several auto-immune diseases, including alopecia areata, lichen planus (auto immune skin nodules), and mycosis fungoides (T-cell skin lymphoma). It is used as first-line treatment for both acute and chronic GVHD of the skin.
Chemical Properties
White or almost white, crystalline powder.
Originator
Dermovate,Glaxo,UK,1973
Uses
Clobetasol-17-propionate is a topical corticosteroid belonging to the group-D (hydrocortisone-q-butyrate) type of steroids.
Uses
For short-term topical treatment of the inflammatory and pruritic manifestations of moderate to severe corticosteroid-responsive dermatoses of the scalp.
Uses
Topical corticosteroid. Glucocorticoid; anti-inflammatory.
Clobetasol propionate (Cormax, Temovate, Embeline, Olux) is one of the most potent of the currently available agents and is indicated for short-term treatment of inflammatory or hyperplastic disorders. It is a synthetic fluorinated corticosteroid. It may cause a more rapid or prolonged response than other topical corticosteroids. It is recommended that clobetasol have a maximum application of 60 g/week for no longer than 14 days without occlusion and that it should not be used in children below age 12.
Definition
ChEBI: The 17-O-propionate ester of clobetasol. A potent corticosteroid, it is used to treat various skin disorders, including exzema and psoriasis.
Indications
Clobetasol propionate (Cormax, Temovate, Embeline, Olux) is one of the most potent of the currently available agents and is indicated for short-term treatment of inflammatory or hyperplastic disorders. It is a synthetic fluorinated corticosteroid. It may cause a more rapid or prolonged response than other topical corticosteroids. It is recommended that clobetasol have a maximum application of 60 g/week for no longer than 14 days without occlusion and that it should not be used in children below age 12.
Manufacturing Process
A solution of betamethasone 21-methanesulfonate (4 g) in dimethylformamide
(25 ml) was treated with lithium chloride (4 g) and the mixture heated on the
steam bath for 30 minutes. Dilution with water gave the crude product which
was recrystallized to afford the title compound, MP 226°C.
Clobetasol is usually converted to the propionate as the useful form by
reaction with propionic anhydride.
brand name
Clobex (Galderma); Clobex (Galderma); Embeline (Healthpoint); Olux (Connetics); Temovate (Altana).
Therapeutic Function
Corticosteroid, Antiinflammatory
Clobetasol propionate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Wuhan Zenuo Biopharmaceutical Technology Co., Ltd | 027-87781970 15172508891 | 1505560767@qq.com | China | 132 | 58 |
| Shandong Yuhe Pharmaceutical Technology Co., LTD | 15263077727 | 1436425847@qq.com | China | 296 | 58 |
| Wuhan Juchengyuan Biotechnology Co., Ltd | 400-027-6007 18062142210 | 804180422@qq.com | China | 145 | 58 |
| Wuhan Biocar Pharmacy CO.,Ltd. | 86-027-86589876 15377519203 | 2094286327@qq.com | China | 548 | 58 |
| GUANGZHOU TOPWORK CHEMISTRY CO.,LTD. | 020-87317062 13048089691 | 852378519@qq.com | China | 259 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
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- Clobetasol propionate is a topical steroid drug with anti-inflammatory, antipruritic, vasoconstrictive and immunomodulatory pr....
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View Lastest Price from Clobetasol propionate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-12 | Clobetasol propionate
25122-46-7
|
0.99 | RongNa Biotechnology Co.,Ltd | ||||
 |
2026-09-11 | Clobetasol Propionate
25122-46-7
|
1g | More Than 99% | 100kg/Month | BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD. | ||
 |
2026-09-11 | Clobetasol propionate
25122-46-7
|
10g | 97%~102%,USP38 | 50kg | WUHAN FORTUNA CHEMICAL CO., LTD |
-
- Clobetasol propionate
25122-46-7
- 0.99
- RongNa Biotechnology Co.,Ltd
-
- Clobetasol Propionate
25122-46-7
- $0.00
- More Than 99%
- BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
-
- Clobetasol propionate
25122-46-7
- 97%~102%,USP38
- WUHAN FORTUNA CHEMICAL CO., LTD
