SM 7368
- CAS No.
- 380623-76-7
- Chemical Name:
- SM 7368
- Synonyms
- SM-7368;SM 7368;SM-7368, 10 mM in DMSO;SM 7368, NF-kappaB inhibitor;NFκB Activation Inhibitor III;NF-oB Activation Inhibitor III;3-Chloro-4-nitro-N-(5-nitrothiazol-2-yl)benzamide;3-Chloro-4-nitro-N-(5-nitro-2-thiazolyl)-benzamide;Benzamide, 3-chloro-4-nitro-N-(5-nitro-2-thiazolyl)-;3-Chloro-4-nitro-N-(5-nitro-1,3-thiazol-2-yl)benzamide
- CBNumber:
- CB62750666
- Molecular Formula:
- C10H5ClN4O5S
- Molecular Weight:
- 328.69
- MDL Number:
- MFCD00834007
- MOL File:
- 380623-76-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| NF-κB Activation Inhibitor III | 481411 | 5mg | $189 |
| NF-κB Activation Inhibitor III ≥99% | 19083 | 5mg | $98 |
| NF-κB Activation Inhibitor III ≥99% | 19083 | 25mg | $412 |
| NF-ºB Activation Inhibitor III | FQA62376 | 25mg | $905.25 |
| NF-ºB Activation Inhibitor III | FQA62376 | 50mg | $1448 |
| Density | 1.761±0.06 g/cm3(Predicted) |
|---|---|
| storage temp. | 2-8°C |
| solubility | DMSO: soluble10mg/mL (clear solution) |
| form | powder |
| pka | 5.18±0.50(Predicted) |
| color | white to beige |
| InChI | 1S/C10H5ClN4O5S/c11-6-3-5(1-2-7(6)14(17)18)9(16)13-10-12-4-8(21-10)15(19)20/h1-4H,(H,12,13,16) |
| InChIKey | XCHLNGBTHLJLFG-UHFFFAOYSA-N |
| SMILES | [s]1c(ncc1[N+](=O)[O-])NC(=O)c2cc(c(cc2)[N+](=O)[O-])Cl |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H318 | |||||||||
| Precautionary statements | P280-P305+P351+P338 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-41 | |||||||||
| Safety Statements | 26-39 | |||||||||
| WGK Germany | 3 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
SM 7368 price More Price(29)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 481411 | NF-κB Activation Inhibitor III | 380623-76-7 | 5mg | $189 | 2026-04-30 | Buy |
| Cayman Chemical | 19083 | NF-κB Activation Inhibitor III ≥99% | 380623-76-7 | 5mg | $98 | 2026-04-30 | Buy |
| Cayman Chemical | 19083 | NF-κB Activation Inhibitor III ≥99% | 380623-76-7 | 25mg | $412 | 2026-04-30 | Buy |
| Biosynth | FQA62376 | NF-ºB Activation Inhibitor III | 380623-76-7 | 25mg | $905.25 | 2026-06-04 | Buy |
| Biosynth | FQA62376 | NF-ºB Activation Inhibitor III | 380623-76-7 | 50mg | $1448 | 2026-06-04 | Buy |
SM 7368 Chemical Properties,Uses,Production
Uses
NFkappaB Activation Inhibitor III is a TNF-α-stimulated NF kappa B activation inhibitor.
Biological Activity
nf-κb activation inhibitor iii is a nf-κb inhibitor.nf-κb (nuclear factor kappa-light-chain-enhancer of activated b cells) is a protein complex controling transcription of dna, cytokine production as well as cell survival. nf-κb is found in nearly all animal cell types and is involved in cellular responses to stimuli such as cytokines, stress, free radicals, heavy metals, and bacterial or viral antigens.
in vitro
previous study found that nf-κb activation inhibitor iii could inhibite tnf-a-induced mmp-9 upregulation in concentration-dependently and showed maximal activity at 10 μm. nf-κb activation inhibitor iii also inhibited tnf-a-induced mmp-9 mrna transcript accumulation and protein expression. it was also found that nf-κb activation inhibitor iii strongly inhibited tnf-a-induced nf-jb activity but not ap-1 activity. in addition, nf-κb activation inhibitor iii was able to strongly inhibit the tnf-a-induced invasion of ht1080 human fibrosarcoma cell line. these findings demonstrated that nf-κb activation inhibitor iii was a synthetic compound inhibiting tnf-a-induced mmp-9 expression, and therefore nf-κb activation inhibitor iii would be useful for the development of chemotherapy targeting tnf-a-mediated tumor invasion and metastasis [1]. nf-κb activation inhibitor iii was used to disrupt nf-κb signaling to evaluate the role of syndecans in mediating extracellular matrix integrity [2].
IC 50
NF-κB; MMP-9; p38 MAP kinase
References
[1] h. y. lee, k. s. park, m. k. kim, et al. a small compound that inhibits tumor necrosis factor-α-induced matrix metalloproteinase-9 upregulation. biochemical and biophysical research communications 336(2), 716-722 (2005).
[2] h. yang, h. liu, x. li, et al. tnf-α and tgf-β1 regulate syndecan-4 expression in nucleus pulposus cells: role of the mitogen-activated protein kinase and nf-κb pathways. connect.tissue res. 56(4), 281-287 (2015).
SM 7368 Preparation Products And Raw materials
Raw materials
Preparation Products
SM 7368 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52906 | 58 | |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 13636370518 | shyysw007@163.com | China | 89667 | 60 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 9739 | 55 |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 7994 | 62 |
| MQ (shanghai) Pharmaceuticals Co., Ltd. | 13761635123 | sales@linyuepharm.com | China | 5694 | 55 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8137 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44871 | 58 |
