1,1-Cyclopropanedicarboxylic acid monomethyl ester
- CAS No.
- 113020-21-6
- Chemical Name:
- 1,1-Cyclopropanedicarboxylic acid monomethyl ester
- Synonyms
- 1-(Methoxycarbonyl)cyclopropane-1-carboxylic acid;1-(methoxycarbonyl)cyclopropanecarboxylic acid;Oliceridine Impurity 23;Cyclopropane-1,1-dicarboxylicacid,Methy;Cyclopropyl -1, 1-diformate mono-tyrosol;113020-21-6;1,1-Cyclopropanedicarboxylic acid-1-methyl e;Monomethyl 1,1-cyclopropyl dicarboxylic acid;CYCLOPROPANE-1,1-DICARBOXYLIC ACID, METHYL ESTER;1,1-CYCLOPROPANEDICARBOXYLIC ACID-1-METHYL ESTER
- CBNumber:
- CB6275637
- Molecular Formula:
- C6H8O4
- Molecular Weight:
- 144.13
- MDL Number:
- MFCD06800496
- MOL File:
- 113020-21-6.mol
| Product description | Number | Pack Size | Price |
| 1-(methoxycarbonyl)cyclopropane-1-carboxylicacid | B485993 | 250mg | $55 |
| 1-(methoxycarbonyl)cyclopropane-1-carboxylicacid | B485993 | 500mg | $65 |
| 1-(methoxycarbonyl)cyclopropane-1-carboxylicacid | B485993 | 100mg | $45 |
| Cyclopropane-1,1-dicarboxylic acid, methylester | FC147198 | 1g | $50 |
| Cyclopropane-1,1-dicarboxylicacid,methylester | Y7088 | 1g | $21 |
| More product size | |||
| Melting point | 47-51°C |
|---|---|
| Boiling point | 85-87°C/0.2mm |
| Density | 1.419 |
| Flash point | 104 °C |
| storage temp. | Sealed in dry,Room Temperature |
| form | crystalline solid |
| pka | 3.37±0.20(Predicted) |
| color | White |
| Water Solubility | Slightly soluble in water. |
| InChI | InChI=1S/C6H8O4/c1-10-5(9)6(2-3-6)4(7)8/h2-3H2,1H3,(H,7,8) |
| InChIKey | IZYOHLOUZVEIOS-UHFFFAOYSA-N |
| SMILES | C1(C(O)=O)(C(OC)=O)CC1 |
| UNSPSC Code | 12352106 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P280g-P305+P351+P338 | |||||||||
| Hazard Codes | Xi,T | |||||||||
| Risk Statements | 25-52 | |||||||||
| Safety Statements | 45 | |||||||||
| RIDADR | UN2811 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 2917200090 | |||||||||
| NFPA 704 |
|
1,1-Cyclopropanedicarboxylic acid monomethyl ester price More Price(36)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | B485993 | 1-(methoxycarbonyl)cyclopropane-1-carboxylicacid | 113020-21-6 | 250mg | $55 | 2021-12-16 | Buy |
| TRC | B485993 | 1-(methoxycarbonyl)cyclopropane-1-carboxylicacid | 113020-21-6 | 500mg | $65 | 2021-12-16 | Buy |
| TRC | B485993 | 1-(methoxycarbonyl)cyclopropane-1-carboxylicacid | 113020-21-6 | 100mg | $45 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FC147198 | Cyclopropane-1,1-dicarboxylic acid, methylester | 113020-21-6 | 1g | $50 | 2021-12-16 | Buy |
| AK Scientific | Y7088 | Cyclopropane-1,1-dicarboxylicacid,methylester | 113020-21-6 | 1g | $21 | 2021-12-16 | Buy |
1,1-Cyclopropanedicarboxylic acid monomethyl ester Chemical Properties,Uses,Production
Uses
1,1-Cyclopropanedicarboxylic acid monomethyl ester is used as a pharmaceutical intermediate.
Synthesis
6914-71-2
113020-21-6
1. KOH (42 mg, 0.75 mmol) was added to a methanolic solution of dimethyl cyclopropane-1,1-dicarboxylate (100 mg, 0.63 mmol). 2. The reaction mixture was stirred at room temperature for 4 hours. 3. After completion of the reaction, the solvent was removed by concentration under reduced pressure. 4. The residue was diluted with water and acidified with concentrated hydrochloric acid to pH<2. 5. The acidified aqueous phase was extracted with dichloromethane (3 x 10 mL). 6. The organic phases are combined and dried over anhydrous sodium sulfate. 7. The desiccant was removed by filtration and the filtrate was concentrated under reduced pressure to give cyclopropane-1,1-dicarboxylic acid monomethyl ester (65 mg, 71% yield) as a white solid.
References
[1] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 6, p. 2188 - 2193
[2] Patent: US2009/239848, 2009, A1. Location in patent: Page/Page column 33
[3] Patent: WO2012/74761, 2012, A1. Location in patent: Page/Page column 20-21
[4] Organic Letters, 2011, vol. 13, # 16, p. 4180 - 4183
[5] Patent: EP1577301, 2005, A1. Location in patent: Page/Page column 148
1,1-Cyclopropanedicarboxylic acid monomethyl ester Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20174 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29735 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21618 | 55 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3009 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29850 | 58 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 8497 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49975 | 58 |
| AFINE CHEMICALS LIMITED | +86-0571-85134551 | sales@afinechem.com | China | 15131 | 58 |
View Lastest Price from 1,1-Cyclopropanedicarboxylic acid monomethyl ester manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2025-09-25 | 1,1-Cyclopropanedicarboxylic acid monomethyl ester
113020-21-6
|
US $8.00-2.00 / kg | 1kg | 99% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd | |
 |
2019-08-27 | 1,1-Cyclopropanedicarboxylic acid monomethyl ester
113020-21-6
|
US $1.00 / KG | 1KG | 95%-99% | 1000kg | Career Henan Chemical Co |
-
- 1,1-Cyclopropanedicarboxylic acid monomethyl ester
113020-21-6
- US $8.00-2.00 / kg
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 1,1-Cyclopropanedicarboxylic acid monomethyl ester
113020-21-6
- US $1.00 / KG
- 95%-99%
- Career Henan Chemical Co
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