Phenylpropiolic acid
- CAS No.
- 637-44-5
- Chemical Name:
- Phenylpropiolic acid
- Synonyms
- 3-Phenylpropiolic acid;PHENYLPROPYNOIC ACID;Benzenepropiolic acid;3-PHENYLPROPYNOIC ACID;RARECHEM AL BE 0668;phenylpropanic acid;PHENYLPROPIOLIC ACID;3-phenyl-2-propynoate;Phenylpropioplic Acid;B-PHENYLPROPIOLIC ACID
- CBNumber:
- CB6290870
- Molecular Formula:
- C9H6O2
- Molecular Weight:
- 146.14
- MDL Number:
- MFCD00004361
- MOL File:
- 637-44-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Phenylpropiolic acid 99% | P31205 | 5g | $50.4 |
| Phenylpropiolic acid 99% | P31205 | 25g | $119 |
| Phenylpropiolic Acid >98.0%(T) | P0610 | 5g | $59 |
| Phenylpropiolic Acid >98.0%(T) | P0610 | 25g | $211 |
| Phenylpropiolic Acid | P336305 | 10g | $165 |
| More product size | |||
| Melting point | 135-137 °C (lit.) |
|---|---|
| Boiling point | 225.74°C (rough estimate) |
| Density | 1.1674 (rough estimate) |
| refractive index | 1.5550 (estimate) |
| storage temp. | 2-8°C |
| pka | pK1:2.269 (35°C) |
| form | Fine Crystalline Powder |
| color | White to slightly beige |
| Water Solubility | freely soluble |
| BRN | 742587 |
| InChI | InChI=1S/C9H6O2/c10-9(11)7-6-8-4-2-1-3-5-8/h1-5H,(H,10,11) |
| InChIKey | XNERWVPQCYSMLC-UHFFFAOYSA-N |
| SMILES | C(O)(=O)C#CC1=CC=CC=C1 |
| CAS DataBase Reference | 637-44-5(CAS DataBase Reference) |
| FDA UNII | 4KE28XZ9GX |
| NIST Chemistry Reference | Phenylpropiolic acid(637-44-5) |
| EPA Substance Registry System | 2-Propynoic acid, 3-phenyl- (637-44-5) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36-24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29163900 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
Phenylpropiolic acid price More Price(37)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | P31205 | Phenylpropiolic acid 99% | 637-44-5 | 5g | $50.4 | 2026-04-30 | Buy |
| Sigma-Aldrich | P31205 | Phenylpropiolic acid 99% | 637-44-5 | 25g | $119 | 2026-04-30 | Buy |
| TCI Chemical | P0610 | Phenylpropiolic Acid >98.0%(T) | 637-44-5 | 5g | $59 | 2026-04-30 | Buy |
| TCI Chemical | P0610 | Phenylpropiolic Acid >98.0%(T) | 637-44-5 | 25g | $211 | 2026-04-30 | Buy |
| TRC | P336305 | Phenylpropiolic Acid | 637-44-5 | 10g | $165 | 2021-12-16 | Buy |
Phenylpropiolic acid Chemical Properties,Uses,Production
Chemical Properties
WHITE TO SLIGHTLY BEIGE FINE CRYSTALLINE POWDER
Uses
Phenylpropiolic Acid is used as a reagent in the high yield synthesis of 3,3-diphenylpropanoic acid derivatives via hydrophenylation and ionic hydrogenation with strong Lewis acids. It is also used in the synthesis of highly substituted aromatic rings via the alkyne-mediated approach which serve as templates for drug design.
Definition
ChEBI: An acetylenic compound that is propynoic acid in which the acetylenic hydrogen is replaced by a phenyl group.
Synthesis
Add phenylacetylene 6 mmol and ultra-dry tetrahydrofuran 25-30 mL in a 100 mL reaction flask, followed by evacuation treatment, N2 protection, put the reaction flask into an ethanol solution at -78C, and then continue to add n-butyllithium 6 mmol, and after 1-1.5 h of reaction, access to a carbon dioxide balloon (inserted into the liquid level), and after 3-4 h of reaction, change the carbon dioxide balloon once again After 3-4 h of reaction, the reaction was replaced with another carbon dioxide balloon, and the reaction was carried out overnight. Afterwards, the reaction bottle was removed and stirred at room temperature to room temperature, 20mL of saturated ammonium chloride solution was added to the reaction bottle, and stirring was continued for 20-30 minutes. At the end of the reaction, it was first extracted with ether (220mL), and the aqueous phase was taken and the pH was adjusted to about 3 with dilute hydrochloric acid, and then ethyl acetate (220mL) was used, and the product phenylpropiolic acid was obtained by spin-drying at low pressure.
Purification Methods
Crystallise the acid from *benzene, CCl4 (m 136o) or aqueous EtOH. The S-benzylisothiuronium salt has m 184-186o (from EtOH). [Beilstein 9 II 436, 9 III 3061, 9 IV 2327.]
Phenylpropiolic acid Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8738 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531151365 | mina@chuanghaibio.com | China | 18126 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29640 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29819 | 58 |
| Changzhou Ansciep Chemical Co., Ltd. | +86 519 86305871 | sales@ansciepchem.com | CHINA | 4241 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49977 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569262 +86-15003564040 | 1056@dideu.com | China | 3982 | 58 |
| Richest Group Ltd | 18017061086 | oled@richest-group.com | CHINA | 5600 | 58 |
View Lastest Price from Phenylpropiolic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-03-20 | Phenylpropiolic acid
637-44-5
|
US $1.00 / KG | 1KG | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2025-12-01 | Phenylpropiolic acid
637-44-5
|
US $0.00 / kg | 1kg | 99% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd | |
 |
2025-06-27 | Phenylpropiolic acid
637-44-5
|
US $0.00-0.00 / KG | 1KG | 99% | 500000kg | Hebei Chuanghai Biotechnology Co., Ltd |
-
- Phenylpropiolic acid
637-44-5
- US $1.00 / KG
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- Phenylpropiolic acid
637-44-5
- US $0.00 / kg
- 99%
- Shaanxi Dideu New Materials Co. Ltd
-
- Phenylpropiolic acid
637-44-5
- US $0.00-0.00 / KG
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
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