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2,6-DIMETHYLANILINE HYDROCHLORIDE

2,6-DIMETHYLANILINE HYDROCHLORIDE structure

CAS No.: 21436-98-6

Chemical Name:: 2,6-DIMETHYLANILINE HYDROCHLORIDE

Synonyms: Einecs 244-388-1;CompoundAR0033QU;ROPIVACAINE RC A;Compound AR0033QU;Lidocaine Impurity 50;Ropivacaine Impurity A;2,6-DimethylanilineHCl;2,6-xylidinium chloride;Bupivacaine EP Impurity F;2,6-XYLIDINE HYDROCHLORIDE

CBNumber:: CB6299479

Molecular Formula:: C8H12ClN

Molecular Weight:: 157.64

MDL Number:: MFCD00060213

MOL File:: 21436-98-6.mol

MSDS File:: SDS

Last updated:2026-05-28 02:09:59

Product description	Number	Pack Size	Price
2,6-Dimethylaniline hydrochloride ≥98%	901252	1G	$47.1
Ropivacaine Related Compound A certified reference material, pharmaceutical secondary standard	PHR2572	50MG	$601
2,6-Dimethylaniline hydrochloride ≥98%	901252	5G	$129
Ropivacaine Related Compound A United States Pharmacopeia (USP) Reference Standard	1605512	25mg	$1570
2,6-Dimethylaniline Hydrochloride >98.0%(HPLC)(N)	X0029	25g	$172
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2,6-DIMETHYLANILINE HYDROCHLORIDE Properties

Melting point	275°C
storage temp.	Inert atmosphere,Room Temperature
solubility	DMSO (Slightly), Methanol (Slightly, Sonicated)
form	powder or crystals
color	White to Pale Brown
Stability	Hygroscopic
InChI	1S/C8H11N.ClH/c1-6-4-3-5-7(2)8(6)9;/h3-5H,9H2,1-2H3;1H
InChIKey	QNWMFJDRMZWZNN-UHFFFAOYSA-N
SMILES	[Cl-].[N+H3]c1c(cccc1C)C
FDA UNII	695APM3L5Y
UNSPSC Code	41116107
NACRES	NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338
Risk Statements	36/37/38
Safety Statements	26-36/37/39
WGK Germany	WGK 3
RTECS	ZF0375000
HS Code	2921490002
Storage Class	11 - Combustible Solids
Toxicity	rat,LD50,oral,2042mg/kg (2042mg/kg),Journal of Pharmacology and Experimental Therapeutics. Vol. 167, Pg. 223, 1969.

2,6-DIMETHYLANILINE HYDROCHLORIDE price More Price(35)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	901252	2,6-Dimethylaniline hydrochloride ≥98%	21436-98-6	1G	$47.1	2026-04-30	Buy
Sigma-Aldrich	PHR2572	Ropivacaine Related Compound A certified reference material, pharmaceutical secondary standard	21436-98-6	50MG	$601	2026-04-30	Buy
Sigma-Aldrich	901252	2,6-Dimethylaniline hydrochloride ≥98%	21436-98-6	5G	$129	2026-04-30	Buy
Sigma-Aldrich	1605512	Ropivacaine Related Compound A United States Pharmacopeia (USP) Reference Standard	21436-98-6	25mg	$1570	2026-04-30	Buy
TCI Chemical	X0029	2,6-Dimethylaniline Hydrochloride >98.0%(HPLC)(N)	21436-98-6	25g	$172	2026-04-30	Buy

Product number	Packaging	Price	Buy
901252	1G	$47.1	Buy
PHR2572	50MG	$601	Buy
901252	5G	$129	Buy
1605512	25mg	$1570	Buy
X0029	25g	$172	Buy

2,6-DIMETHYLANILINE HYDROCHLORIDE Chemical Properties,Uses,Production

Uses

2,6-Dimethylaniline hydrochloride may be used in the preparation of 2,6-dimethylphenyl isocyanate via phosgenation. This product was previously listed as CDS000447.

Synthesis

2198-53-0

925-90-6

21436-98-6

The general procedure for the synthesis of 2,6-dimethylaniline hydrochloride from 2,6-dimethylacetanilide and ethylmagnesium bromide was as follows: trifluoromethanesulfonic anhydride (Tf2O, 185 μL, 1.1 mmol) was added slowly and dropwise to a cooled-to-0°C dichloromethane ( 4 mL) solution. The reaction mixture was stirred at 0 °C for 30 min, then transferred to -78 °C and a solution of tetrahydrofuran (THF, 15 mL) of freshly prepared organocerium reagent/complex (3.0 mmol) was added, and stirring was continued for 2 hours. Upon completion of the reaction, the reaction was quenched by the addition of a 3 mol/L aqueous hydrochloric acid solution (5 mL) and the mixture was gradually warmed to room temperature with continued stirring for 2 hours. Subsequently, 25% ammonium hydroxide solution (5 mL) was added to the mixture. The organic layer was separated and the aqueous phase was extracted with ether (3 x 10 mL). The organic layers were combined, washed with saturated saline (3 x 3 mL) and concentrated under reduced pressure to about 1/3 of the original volume. the residual organic phase was extracted with 3 mol/L aqueous hydrochloric acid solution (3 x 5 mL). The separated organic phase was washed with saturated saline (5 mL), dried with anhydrous magnesium sulfate (MgSO4), filtered and concentrated under reduced pressure, and the residue was purified by silica gel fast column chromatography to obtain the target ketone product. All aqueous phases were combined, washed with ether (5 mL) and alkalized with 25% ammonium hydroxide solution (5 mL), then back-extracted with ether (5×20 mL). The ether layers were combined, washed with saturated saline (5 mL), dried over anhydrous magnesium sulfate (MgSO4), filtered and acidified with 3 mol/L ethyl acetate hydrochloride solution (5 mL), and finally concentrated under reduced pressure to give 2,6-dimethylaniline hydrochloride.

References

[1] Chinese Chemical Letters, 2015, vol. 26, # 9, p. 1055 - 1058

2,6-DIMETHYLANILINE HYDROCHLORIDE synthesis

Synthesis of 2,6-DIMETHYLANILINE HYDROCHLORIDE from 2',6'-DIMETHYLACETANILIDE and Ethylmagnesium bromide

2,6-DIMETHYLANILINE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

2',6'-DIMETHYLACETANILIDE Ethylmagnesium bromide 2,6-Dimethylaniline 2,6-Dimethyl-1-nitrobenzene CERIUM(III) CHLORIDE

Hydrochloric acid Ethyl acetate 2-Fluoropyridine Dichloromethane Tetrahydrofuran

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Preparation Products

2,6-Dimethylphenyl isocyanate

2,6-DIMETHYLANILINE HYDROCHLORIDE Suppliers

Global( 125)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Apeloa production Co.,Limited	+8619933239880	admin@apcl.com.cn	China	861	58
Moxin Chemicals	+86-17320513646 +8617320513646	anna@molcoo.com	China	10000	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29792	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +8618949823763	sales@tnjchem.com	China	34563	58
AFINE CHEMICALS LIMITED	+86-0571-85134551	sales@afinechem.com	China	15083	58
Dayang Chem (Hangzhou) Co.,Ltd.	+86-0571-88938639 +8617705817739	info@dycnchem.com	China	52705	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471;	sales@sarms4muscle.com	China	10473	58
sgtlifesciences pvt ltd	+8617013299288	dj@sgtlifesciences.com	China	12373	58
PT CHEM GROUP LIMITED	+86-85511178;	peter68@ptchemgroup.com	China	35425	58
GIHI CHEMICALS CO.,LIMITED	+86-571-86217390; +8618058761490	info@gihichemicals.com	China	49969	58

Supplier	Advantage
Apeloa production Co.,Limited	58
Moxin Chemicals	58
career henan chemical co	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
AFINE CHEMICALS LIMITED	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
Zhejiang J&C Biological Technology Co.,Limited	58
sgtlifesciences pvt ltd	58
PT CHEM GROUP LIMITED	58
GIHI CHEMICALS CO.,LIMITED	58

View Lastest Price from 2,6-DIMETHYLANILINE HYDROCHLORIDE manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-12-16	Ropivacaine EP Impurity H(Hydrochloride) 21436-98-6		10mg	99%+ HPLC	1000	Moxin Chemicals
2025-02-13	2,6-Dimethylaniline Hydrochloride 21436-98-6	$1.00	1g	0.98	1000	Apeloa production Co.,Limited
2020-01-13	2,6-DIMETHYLANILINE HYDROCHLORIDE 21436-98-6	$1.00	1KG	98%	10 tons	Career Henan Chemical Co

Ropivacaine EP Impurity H(Hydrochloride)
21436-98-6
99%+ HPLC
Moxin Chemicals

2,6-Dimethylaniline Hydrochloride
21436-98-6
$1.00
0.98
Apeloa production Co.,Limited

2,6-DIMETHYLANILINE HYDROCHLORIDE
21436-98-6
$1.00
98%
Career Henan Chemical Co

2,6-DIMETHYLANILINE HYDROCHLORIDE Spectrum

2,6-DIMETHYLANILINE HYDROCHLORIDE(21436-98-6)MS 2,6-DIMETHYLANILINE HYDROCHLORIDE(21436-98-6)¹HNMR 2,6-DIMETHYLANILINE HYDROCHLORIDE(21436-98-6)¹³CNMR 2,6-DIMETHYLANILINE HYDROCHLORIDE(21436-98-6)IR1 2,6-DIMETHYLANILINE HYDROCHLORIDE(21436-98-6)IR2

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2,6-XYLIDINE HYDROCHLORIDE 2,6-DIMETHYLANILINE HYDROCHLORIDE 2,6-xylidinium chloride 2,6-DimethylanilineHCl Einecs 244-388-1 Ropivacaine Related Compound A (25 mg) (2,6-dimethylaniline hydrochloride) Ropivacaine Related CoMpound A Ropivacaine Impurity A 2,6-DIMETHYLANILINE HYDROCHLORIDE 98+% Bupivacaine EP Impurity F HCl (Ropivacaine EP Impurity H HCl) Bupivacaine EP Impurity F HCl Ropivacaine EP Impurity H HCl Ropivacaine EP Impurity H HCl (Bupivacaine EP Impurity F HCl) Bupivacaine EP Impurity F 2,-6-Dimethylaniline Hydrochloride Certified Reference Standard Ropivacaine RC A / Ropivacaine EP Impurity H Ropivacaine Related Compound A.HCl Ropivacaine Related Compound A (2,6-dimethylaniline hydrochloride) (1605512) Lidocaine Hydrochloride Impurity A as Hydrochloride Ropivacaine Related Compound A as Hydrochloride Lidocaine Hydrochloride EP Impurity A as Hydrochloride Ropivacaine USP Related Compound A as Hydrochloride Compound AR0033QU CompoundAR0033QU Lidocaine EP Impurity A(Bupivacaine EP Impurity F Bupivacaine EP Impurity F(Ropivacaine EP Impurity H HCl) Lidocaine Impurity 50 ROPIVACAINE RC A Dapagliflozin Impurity 125 Lidocaine EP Impurity A HCl Lidocaine EP Impurity A HCl (Bupivacaine EP Impurity F HCl, Ropivacaine EP Impurity H HCl, Ropivacaine USP Related Compound A) ROPIVACAINE RELATED COMPOUND A (2LOTS) Ropivacaine EP Impurity H(Hydrochloride) 21436-98-6 C8H11NHCl