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XPhos Pd G4

XPhos Pd G4 Structure
XPhos Pd G4 structure
CAS No.
1599466-81-5
Chemical Name:
XPhos Pd G4
Synonyms
XPhos Pd G4;XPhosPalladacycleG4;XPhos Pd G4 ChemBeads;Xphos Palladacycle Gen.4;Methanesulfonato(2-dicyclohexylphosphino-2',4',6'-...;(2dicyclohexylphosphino2′,4′,6′triisopropyl1,1′biphenyl)[2(2′methylamino1,1′biphenyl)]palladium(II) methanesulfonate;Methanesulfonato(2-dicyclohexylphosphino-2',4',6'-tri-i-propyl-1,1'-biphenyl)(2'-methylamino-1,1'-biphenyl-2-yl)palladium(II);methanesulfonylacid(2-dicyclohexylphosphinoyl-2',4',6'-tri-isopropyl-1,1'-biphenyl)(2'-methylamineyl-1,1'-biphenyl-2-yl)paladium(I-I);XPhos Pd G4 / Methanesulfonato(2-dicyclohexylphosphino-2',4',6'-tri-i-propyl-1,1'-biphenyl)(2'-methylamino-1,1'-biphenyl-2-yl)palladium(II);Methanesulfonato(2-dicyclohexylphosphino-2',4',6'-tri-i-propyl-1,1'-biphenyl)(2'-methylamino-1,1'-biphenyl-2-yl)palladium(II) (XPhos Pd G4)
CBNumber:
CB63139770
Molecular Formula:
C47H64NO3PPdS
Molecular Weight:
860.49
MDL Number:
MFCD29049345
MOL File:
1599466-81-5.mol
MSDS File:
SDS
Last updated:2026-01-13 11:22:13
Product description Number Pack Size Price
XPhos Pd G4 95% 804274 250mg $76.7
XPhos Pd G4 95% 804274 1g $226
XPhos Pd G4 95% 804274 5 g $842
XPhos Pd G4 95% 804274 1 unit $679.4
XPhos Pd G4 95% 804274 1 unit $679.4
More product size
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XPhos Pd G4 Properties

Melting point 150 °C
storage temp. 2-8°C, protect from light, stored under nitrogen
form Powder
color white to off-white
InChIKey RWNNUNWRORBXQJ-UHFFFAOYSA-N
SMILES P(C1CCCCC1)(C1CCCCC1)(C1C=CC=CC=1C1C(=CC(C(C)C)=CC=1C(C)C)C(C)C)[Pd+2]1(N(C2=CC=CC=C2C2=CC=CC=[C-]12)C)[O-]S(=O)(=O)C
UNSPSC Code 31191513
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H335-H315-H319
Precautionary statements  P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362
WGK Germany  WGK 3
Storage Class 11 - Combustible Solids

XPhos Pd G4 price More Price(17)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 804274 XPhos Pd G4 95% 1599466-81-5 250mg $76.7 2026-03-19 Buy
Sigma-Aldrich 804274 XPhos Pd G4 95% 1599466-81-5 1g $226 2026-03-19 Buy
Sigma-Aldrich 804274 XPhos Pd G4 95% 1599466-81-5 5 g $842 2026-03-19 Buy
Sigma-Aldrich 804274 XPhos Pd G4 95% 1599466-81-5 1 unit $679.4 2025-07-31 Buy
Sigma-Aldrich 804274 XPhos Pd G4 95% 1599466-81-5 1 unit $679.4 2025-07-31 Buy
Product number Packaging Price Buy
804274 250mg $76.7 Buy
804274 1g $226 Buy
804274 5 g $842 Buy
804274 1 unit $679.4 Buy
804274 1 unit $679.4 Buy

XPhos Pd G4 Chemical Properties,Uses,Production

Chemical Properties

Powder. Bench stable, soluble in most organic solvents.

Uses

XPhos Pd G4 is a powerful ligand for classic cross-coupling reactions combined with the Buchwald Fourth Generation Palladacycle.

Reactions

Palladium catalyst used in the Suzuki-Miyaura coupling of unstable boronic acids. Reactions of 1599466-81-5

reaction suitability

reaction type: Buchwald-Hartwig Cross Coupling Reaction
reaction type: Cross Couplings
reaction type: Heck Reaction
reaction type: Hiyama Coupling
reaction type: Negishi Coupling
reaction type: Sonogashira Coupling
reaction type: Stille Coupling
reaction type: Suzuki-Miyaura Coupling
reagent type: catalyst

Synthesis

A dry round-bottomed flask (25 mL) was equipped with a stirring bar and then palladium dimer methanesulfonate (1 mmol) and XPhos (0.953 g) were added to the reaction flask under nitrogen atmosphere. Dry dichloromethane was added to the above reaction mixture as reaction solvent (10 mL) and the mixture was stirred at room temperature for 16 hours. At the end of the reaction the resulting reaction mixture was concentrated under vacuum making the total volume of the mixture about 1-2 mL. To the above reaction mixture n-pentane (20 mL) was added to precipitate a black solid and the mixture was filtered. The resulting filtrate was concentrated in vacuo to afford XPhos Pd G4, (SP-4-3)-[dicyclohexyl[2',4',6'-tris(isopropyl)[1,1'-biphenyl]-2-yl]phosphine](methanesulfonic acid)[2'-(methylamino)[1,1'-biphenyl]-2-yl]palladium.

XPhos Pd G4 synthesis

1581285-85-9
564483-18-7
1599466-81-5
Synthesis of XPhos Pd G4 from (2'-Methylamino-1,1'-biphenyl-2-yl)methanesulfonatopalladium(II) dimer and X-PHOS

XPhos Pd G4 Preparation Products And Raw materials

Raw materials

X-PHOS (2'-Methylamino-1,1'-biphenyl-2-yl)methanesulfonatopalladium(II) dimer

Preparation Products

XPhos Pd G4 Suppliers

Global( 119)Suppliers
Supplier Tel Email Country ProdList Advantage
Wuhan Huahan Dingcheng New Material Technology Co., Ltd
+undefined-027-81388558 +undefined086-1878077615 huahandingcheng@sina.com China 342 58
XINXIANG RUNYU MATERIAL CO., LTD.
+86-13592593621; +8613592593621 sales@runvmat.com China 453 58
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD 		+86-13017695106 +86-13676922317 jiuyitime@fdachem.com China 16513 58
Shanghai Daken Advanced Materials Co.,Ltd 		+86-2158073036 info@dakenam.com China 13815 58
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
Accela ChemBio Inc. 		+1-858-6993322 info@accelachem.com United States 21193 58
Shaanxi Dideu Medichem Co. Ltd 		+86-029-81138252 +86-173 9270 1263 1057@dideu.com China 4000 58
Richest Group Ltd 		18017061086 oled@richest-group.com CHINA 5600 58
Antai Fine Chemical Technology Co.,Limited 		18503026267 info@antaichem.com CHINA 9636 58
SHANGHAI T&W PHARMACEUTICAL CO., LTD. 		+86-021-61551413 +8618813727289 contact@trustwe.com China 5742 58
Supplier Advantage
Wuhan Huahan Dingcheng New Material Technology Co., Ltd
58
XINXIANG RUNYU MATERIAL CO., LTD.
58
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD 		58
Shanghai Daken Advanced Materials Co.,Ltd 		58
ATK CHEMICAL COMPANY LIMITED 		60
Accela ChemBio Inc. 		58
Shaanxi Dideu Medichem Co. Ltd 		58
Richest Group Ltd 		58
Antai Fine Chemical Technology Co.,Limited 		58
SHANGHAI T&W PHARMACEUTICAL CO., LTD. 		58

View Lastest Price from XPhos Pd G4 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
XPhos Pd G4 pictures 2026-04-24 XPhos Pd G4
1599466-81-5
 US $0.00 / KG 1KG 98%min 30tons/month WUHAN FORTUNA CHEMICAL CO., LTD
Methanesulfonato(2-dicyclohexylphosphino-2',4',6'-tri-i-propyl-1,1'-biphenyl)(2'-methylamino-1,1'-biphenyl-2-yl)palladium(II) pictures 2026-04-17 Methanesulfonato(2-dicyclohexylphosphino-2',4',6'-tri-i-propyl-1,1'-biphenyl)(2'-methylamino-1,1'-biphenyl-2-yl)palladium(II)
1599466-81-5
 US $2.00-5.00 / kg 1kg 99% 100kg ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
XPhos Palladacycle Gen. 4 pictures 2022-12-08 XPhos Palladacycle Gen. 4
1599466-81-5
 US $1.00 / G 1G 98% 500KG Wuhan Huahan Dingcheng New Material Technology Co., Ltd
  • XPhos Pd G4 pictures
  • XPhos Pd G4
    1599466-81-5
  • US $0.00 / KG
  • 98%min
  • WUHAN FORTUNA CHEMICAL CO., LTD

1599466-81-5(XPhos Pd G4)Related Search:

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XPhos Pd G2 RuPhos Pd G1 Methyl t--Butyl Ether Adduct SPhos Pd G2 BrettPhosPalladacycle Palladacycle Gen. 3
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(SP-4-3)-[Dicyclohexyl[2',4',6'-tris(1-methylethyl)[1,1'-biphenyl]-2-yl]phosphine](methanesulfonato)[2'-(methylamino)[1,1'-biphenyl]-2-yl]palladium Methanesulfonato(2-dicyclohexylphosphino-2',4',6'-tri-i-propyl-1,1'-biphenyl)(2'-methylamino-1,1'-biphenyl-2-yl)palladium(II) Methanesulfonato(2-dicyclohexylphosphino-2',4',6'-tri-i-propyl-1,1'-biphenyl)(2'-methylamino-1,1'-biphenyl-2-yl)palladium(II),[XPhos Palladacycle Gen. 4] Xphos Palladacycle Gen.4 METHANESULFONATO(2-DICYCLOHEXYLPHOSPHINO-2',4',6'-TRI-I-PROPYL-1,1'-BIPHENYL)(2'-METHYLAMINO-1,1'-BIPHENYL-2-YL)PALLADIUM(II),MIN.98%[XPHOSPALLADACYCLEGEN.4] (2dicyclohexylphosphino2′,4′,6′triisopropyl1,1′biphenyl)[2(2′methylamino1,1′biphenyl)]palladium(II) methanesulfonate Methanesulfonato(2-dicyclohexylphosphino-2',4',6'-tri-i-propyl-1,1'-biphenyl)(2'-methylamino-1,1'-biphenyl-2-yl)palladium(II) / XPhos Pd G4 Methanesulfonato(2-dicyclohexylphosphino-2',4',6'-... XPhosPalladacycleG4 XPhos Pd G4 / Methanesulfonato(2-dicyclohexylphosphino-2',4',6'-tri-i-propyl-1,1'-biphenyl)(2'-methylamino-1,1'-biphenyl-2-yl)palladium(II) XPhos Pd G4 Methanesulfonato(2-dicyclohexylphosphino-2',4',6'-tri-i-propyl-1,1'-biphenyl)(2'-methylamino-1,1'-biphenyl-2-yl)palladium(II) (XPhos Pd G4) XPhos Pd G4 ChemBeads Methanesulfonicacid(2-dicyclohexylphosphino-2',4',6'-triisopropyl-1,1'-biphenyl)(2'-methylamino-1,1'-biphenyl-2-yl)palladium(II),[XPhosPalladacycleGen.4] methanesulfonylacid(2-dicyclohexylphosphinoyl-2',4',6'-tri-isopropyl-1,1'-biphenyl)(2'-methylamineyl-1,1'-biphenyl-2-yl)paladium(I-I) 1599466-81-5 C47H64NO3PPdS Buchwald Ligands&Precatalysts Buchwald Precatalysts Series Pd