CPI 4203
- CAS No.
- 1628214-07-2
- Chemical Name:
- CPI 4203
- Synonyms
- CPI 4203;Pyrazolo[1,5-a]pyrimidine-3-carbonitrile, 6-ethyl-4,7-dihydro-5-(2-methylphenyl)-7-oxo-
- CBNumber:
- CB63146277
- Molecular Formula:
- C16H14N4O
- Molecular Weight:
- 278.31
- MDL Number:
- MOL File:
- 1628214-07-2.mol
CPI 4203 Chemical Properties,Uses,Production
Description
CPI-4203 is a selective inhibitor of KDM5 demethylases, structurally related to CPI 455. The KDM5 family of histone demethylases catalyzes the demethylation of histone H3 on lysine 4 (H3K4) and is required for the survival of drug-tolerant persister cancer cells (DTPs).
Uses
CPI-4203 is a potent KDM5A inhibitor with an IC50 of 250 nM. CPI-4203 is competitive with 2-oxoglutarate (2-OG). CPI-4203 is structurally related to CPI-455 (HY-100421) but is less potent[1].
References
[1] Vinogradova M, et al. An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells. Nat Chem Biol. 2016 Jul;12(7):531-8. DOI:10.1038/nchembio.2085
CPI 4203 Preparation Products And Raw materials
Raw materials
Preparation Products
CPI 4203 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32376 | 58 |
| TargetMol Chemicals Inc. | +17819995354 | marketing@targetmol.com | United States | 19939 | 58 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9803 | 58 |
| BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |
| Jinan Jiuli Biotechnology Co. , Ltd. | 15865264761 | 486064515@qq.com | China | 4774 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24982 | 58 |
| Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | sales@chemhifuture.com | China | 5686 | 58 |
| Hefei Mokai Pharmaceutical Technology Co., Ltd | 19355912709 | 690231469@qq.com | China | 6489 | 58 |
| Biosynth Biological Technology (Suzhou) Co Ltd | 51288865780 | sales@biosynth.com | China | 6051 | 58 |
| Adooq Bioscience LLC | 400-025-6535 | sales@adooq.cn | China | 6215 | 58 |
