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Irofulven

Irofulven Structure
Irofulven structure
CAS No.
920014-72-8
Chemical Name:
Irofulven
Synonyms
RM-493;BIM-22493;IRC-022493);Setmelanodide;Sermelanotide;Setmelanotide (RM-493);RM-493; BIM-22493; IRC-022493);Setmelanotide (RM-493) trifluoroacetate salt;Ac-Arg-c(Cys-D-Ala-His-D-Phe-Arg-Trp-Cys)-NH2;L-Cysteinamide, N2-acetyl-L-arginyl-L-cysteinyl-D-alanyl-L-histidyl-D-phenylalanyl-L-arginyl-L-tryptophyl-, cyclic (2→8)-disulfide
CBNumber:
CB63159918
Molecular Formula:
C49H68N18O9S2
Molecular Weight:
1117.32
MDL Number:
MFCD30532719
MOL File:
920014-72-8.mol
Last updated:2025-08-25 18:08:31
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Irofulven Properties

Density 1.54±0.1 g/cm3(Predicted)
pka 12.82±0.70(Predicted)
form Solid
color White to off-white
Sequence Ac-Arg-Cys-D-Ala-His-D-Phe-Arg-Trp-Cys-NH2(Disulfide bond)
InChIKey HDHDTKMUACZDAA-JFHGRQLZNA-N
FDA UNII N7T15V1FUY

Irofulven price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
DC Chemicals DC10323 Setmelanotide >98% 920014-72-8 1g $2100 2021-12-16 Buy
Product number Packaging Price Buy
DC10323 1g $2100 Buy

Irofulven Chemical Properties,Uses,Production

Uses

Setmelanotide (RM-493) is a selective melanocortin 4 receptor (MC4R) agonist with EC50s of 0.27 nM and 0.28 nM for human and rat MC4R, respectively[1].

in vivo

Inhibition of refeeding after an overnight fast by Setmelanotide is dependent on functional MC4R, and does not require MC3R. BIM-22493 acutely improves glucose homeostasis. Lepob/Lepob mice treated with BIM-22493 exhibits significantly improved glucose clearance when compared to controls. Chronic BIM-22493 treatment was associated with significantly lower levels of serum glucose and HOMA-IR values[1].
Treatment with setmelanotide results in transient decreases in food intake (35%), with persistent weight loss over 8 weeks of treatment (13.5%) in a diet-induced obese nonhuman primate model[2].

References

[1] Kumar KG, et al. Analysis of the therapeutic functions of novel melanocortin receptor agonists in MC3R- and MC4R-deficient C57BL/6J mice. Peptides. 2009 Oct;30(10):1892-900. DOI:10.1016/j.peptides.2009.07.012
[2] Kievit P, et al. Chronic treatment with a melanocortin-4 receptor agonist causes weight loss, reduces resistance, and improves cardiovascular function in diet-induced obese rhesus macaques. Diabetes. 2013 Feb;62(2):490-7. DOI:10.2337/db12-0598

Irofulven Preparation Products And Raw materials

Raw materials

Preparation Products

Irofulven Suppliers

Global( 85)Suppliers
Supplier Tel Email Country ProdList Advantage
Linyi Changqing Chemical Co., LTD 		+86-0532-55729510 +8615853232676 marketing@echemi.com China 322 58
Changsha MOL Changes Biotechnology Co., Ltd.
+8619375158599 info@molchanges.com China 5218 58
Zibo Hangyu Biotechnology Development Co., Ltd 		+86-0533-2185556 +8615965530500 nickzhang@hangyubiotech.com China 10997 58
Jinan Million Pharmaceutical Co., Ltd 		0531-68659554 +8613031714605 info@millionpharm.com China 226 58
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD 		+86-13017695106 +86-13676922317 jiuyitime@fdachem.com China 9029 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21620 55
Shenzhen Nexconn Pharmatechs Ltd 		+86-755-89396905 +86-15013857715 admin@nexconn.com China 10406 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19552 58
Shanghai Longyu Biotechnology Co., Ltd. 		+8619521488211 info@longyupharma.com China 2557 58
Hebei Yanxi Chemical Co., Ltd. 		+8618531123677 faithe@yan-xi.com China 5853 58
Supplier Advantage
Linyi Changqing Chemical Co., LTD 		58
Changsha MOL Changes Biotechnology Co., Ltd.
58
Zibo Hangyu Biotechnology Development Co., Ltd 		58
Jinan Million Pharmaceutical Co., Ltd 		58
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD 		58
Henan Tianfu Chemical Co.,Ltd. 		55
Shenzhen Nexconn Pharmatechs Ltd 		58
BOC Sciences 		58
Shanghai Longyu Biotechnology Co., Ltd. 		58
Hebei Yanxi Chemical Co., Ltd. 		58

View Lastest Price from Irofulven manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Irofulven pictures 2025-09-30 Irofulven
920014-72-8
 US $1.00-1.00 / kg 0.0001kg 99% 50kg Jinan Million Pharmaceutical Co., Ltd
Setmelanotide pictures 2025-08-25 Setmelanotide
920014-72-8
 US $255.00-719.00 / mg 10g TargetMol Chemicals Inc.
Setmelanotide pictures 2025-07-29 Setmelanotide
920014-72-8
 US $2.00-6.00 / kg 1kg 99% 100kg ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
  • Irofulven pictures
  • Irofulven
    920014-72-8
  • US $1.00-1.00 / kg
  • 99%
  • Jinan Million Pharmaceutical Co., Ltd
  • Setmelanotide pictures
  • Setmelanotide
    920014-72-8
  • US $255.00-719.00 / mg
  • TargetMol Chemicals Inc.
  • Setmelanotide pictures
  • Setmelanotide
    920014-72-8
  • US $2.00-6.00 / kg
  • 99%
  • ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

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Setmelanodide BIM-22493 IRC-022493) RM-493 RM-493; BIM-22493; IRC-022493) Ac-Arg-c(Cys-D-Ala-His-D-Phe-Arg-Trp-Cys)-NH2 L-Cysteinamide, N2-acetyl-L-arginyl-L-cysteinyl-D-alanyl-L-histidyl-D-phenylalanyl-L-arginyl-L-tryptophyl-, cyclic (2→8)-disulfide Setmelanotide (RM-493) trifluoroacetate salt Setmelanotide (RM-493) Sermelanotide (7S,16R,19R,22R)-16-((1H-imidazol-5-yl)methyl)-7-((1H-indol-3-yl) methyl)-22-((S)-2-acetamido-5-((diaminomethylene)amino) pentanamido)-13-benzyl-10-(3-((diaminomethylene)amino)propyl)-19-methyl-6,9,12,15,18,21- hexaoxo-1,2-dithia- 5,8,11,14,17,20- hexaazacyclotricosane-4-carboxamide 920014-72-8 C49H68N18O9S2