Nusinersen
- CAS No.
- 1258984-36-9
- Chemical Name:
- Nusinersen
- Synonyms
- NU;Nusinersen;Nusinersen Impurity;Nusinersen USP/EP/BP;Nusinersen(ASO, Oligonucleotides);Nociceptive sodium( Nociceptive sodium)
- CBNumber:
- CB63159938
- Molecular Formula:
- C234H340N61O128P17S17
- Molecular Weight:
- 7127.194237
- MDL Number:
- MOL File:
- 1258984-36-9.mol
| storage temp. | Store at -20°C |
|---|---|
| form | Solid |
| color | White to off-white |
| InChIKey | WWFDJIVIDXJAQR-FFWSQMGZSA-N |
| FDA UNII | 5Z9SP3X666 |
| ATC code | M09AX07 |
Nusinersen Chemical Properties,Uses,Production
Description
Nusinersen is a prescription medication used to treat adult and paediatric spinal muscular atrophy (SMA) by improving peripheral muscle function.SMA is caused by a mutation in a gene called SMN1, which encodes for a protein important for motor neuron survival (survival motor neuron or SMN). Although a nearly identical gene (SMN2) serves as a backup to SMN1, it produces a shorter, less stable protein that does not fully compensate for the loss of the full-length protein normally produced by the SMN1 gene. In contrast, Nusinersen is an antisense oligonucleotide agent that modifies the pre-messenger RNA splicing of the SMN2 gene, thereby facilitating increased production of full-length SMN proteins[1-2].
Uses
Nusinersen can be used to treat adult and paediatric spinal muscular atrophy (SMA) and is also able to improve respiratory function and slow the decline in lung function in paediatric SMA[1].
References
[1] MICHELLE A FARRAR; Matthew C K. Treating adults with spinal muscular atrophy with nusinersen.[J]. Journal of Neurology, Neurosurgery, and Psychiatry, 2020. DOI:10.1136/jnnp-2020-324036.
[2] ARCHANA CHACKO. Effect of nusinersen on respiratory function in paediatric spinal muscular atrophy types 1-3.[J]. Thorax, 2022. DOI:10.1136/thoraxjnl-2020-216564.
Nusinersen Preparation Products And Raw materials
Raw materials
Preparation Products
Nusinersen Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 22866 | 58 |
| Apextide Co Ltd | +86-15300650552 +86-15300650552 | info@apextide.com | China | 92 | 58 |
| Biopole Pharmatech Co., Ltd. | +8615151475053 | biopole@163.com | China | 37 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21628 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10406 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19552 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29807 | 58 |
| AFINE CHEMICALS LIMITED | +86-0571-85134551 | sales@afinechem.com | China | 15417 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8467 | 58 |
View Lastest Price from Nusinersen manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-02-06 | Nusinersen
1258984-36-9
|
US $0.00 / g | 1g | 0.99 | 1kg | Biopole Pharmatech Co., Ltd. | |
 |
2024-02-06 | Nusinersen Sodium
1258984-36-9
|
US $0.00 / g | 1g | 99% HPLC | 10kg | Biopole Pharmatech Co., Ltd. | |
 |
2021-07-29 | Nusinersen USP/EP/BP
1258984-36-9
|
US $1.10 / g | 1g | 99.9% | 100 Tons min | Dideu Industries Group Limited |
-
- Nusinersen
1258984-36-9
- US $0.00 / g
- 0.99
- Biopole Pharmatech Co., Ltd.
-
- Nusinersen Sodium
1258984-36-9
- US $0.00 / g
- 99% HPLC
- Biopole Pharmatech Co., Ltd.
-
- Nusinersen USP/EP/BP
1258984-36-9
- US $1.10 / g
- 99.9%
- Dideu Industries Group Limited