PBT-1033
- CAS No.
- 648896-70-2
- Chemical Name:
- PBT-1033
- Synonyms
- PBT2;PBT-2;PBT 2;PBT-1033;PBT-1033 hydrochloride;PBT1033 hydrochloride,PBT 1033 hydrochloride
- CBNumber:
- CB63161546
- Molecular Formula:
- C12H13Cl3N2O
- Molecular Weight:
- 307.6
- MDL Number:
- MFCD31421064
- MOL File:
- 648896-70-2.mol
- MSDS File:
- SDS
| FDA UNII | 24Z79C941B |
|---|
PBT-1033 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| aablocks | AA01B6YC | 5,7-dichloro-2-[(dimethylamino)methyl]quinolin-8-ol hydrochloride 95% | 648896-70-2 | 50mg | $369 | 2026-05-29 | Buy |
| aablocks | AA01B6YC | 5,7-dichloro-2-[(dimethylamino)methyl]quinolin-8-ol hydrochloride 95% | 648896-70-2 | 100mg | $453 | 2026-05-29 | Buy |
| aablocks | AA01B6YC | 5,7-dichloro-2-[(dimethylamino)methyl]quinolin-8-ol hydrochloride 95% | 648896-70-2 | 250mg | $562 | 2026-05-29 | Buy |
| aablocks | AA01B6YC | 5,7-dichloro-2-[(dimethylamino)methyl]quinolin-8-ol hydrochloride 95% | 648896-70-2 | 500mg | $800 | 2026-05-29 | Buy |
PBT-1033 Chemical Properties, Uses, Production
Uses
PBT 1033 hydrochloride is an orally active copper/zinc ionophore. PBT 1033 hydrochloride restores cognition in mouse models of Alzheimer's disease (AD). PB 1033 also has antibacterial activity against Gram-positive bacteria[1][2].
References
[1] Faux NG, et al. PBT2 rapidly improves cognition in Alzheimer's Disease: additional phase II analyses. J Alzheimers Dis. 2010;20(2):509-16. DOI:10.3233/JAD-2010-1390
[2] Harbison-Price N, et al. Multiple Bactericidal Mechanisms of the Zinc Ionophore PBT2. mSphere. 2020 Mar 18;5(2):e00157-20.
[3] Johanssen T, et al. PBT2 inhibits glutamate-induced excitotoxicity in neurons through metal-mediated preconditioning. Neurobiol Dis. 2015 Sep;81:176-85. DOI:10.1016/j.nbd.2015.02.008
[4] Crouch PJ, et al. The Alzheimer's therapeutic PBT2 promotes amyloid-β degradation and GSK3 phosphorylation via a metal chaperone activity. J Neurochem. 2011 Oct;119(1):220-30. DOI:10.1111/j.1471-4159.2011.07402.x
[5] Adlard PA, et al. Metal ionophore treatment restores dendritic spine density and synaptic protein levels in a mouse model of Alzheimer's disease. PLoS One. 2011 Mar 11;6(3):e17669. DOI:10.1371/journal.pone.0017669
PBT-1033 Preparation Products And Raw materials
Raw materials
Preparation Products
PBT-1033 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Biopharmaleader Co., Ltd. | +86 18721201413 | sales@biopharmaleader.com | China | 1711 | 58 |
| Beijing Solarbio Science & Tecnology Co., Ltd. | 010-50973130 17801761073 | Gsiyu@solarbio.com | China | 50748 | 58 |
| Beijing Boorsen Biotechnology Co., Ltd | 400-901-9800 18611424007 | cis@bioss.com.cn | China | 9185 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29873 | 58 |
| Levin (Wuhan) Institute of Biomedical Research | 13155297675 | wuhan_institute@elevin.cn | China | 2220 | 58 |
| TargetMol Chemicals Inc. | 13564774135 | marketing@targetmol.com | United States | 19950 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 38999 | 58 |
View Latest Price from PBT-1033 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-05-11 | PBT-1033 hydrochloride
648896-70-2
|
$1520.00-2500.00 | 10g | TargetMol Chemicals Inc. |
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- PBT-1033 hydrochloride
648896-70-2
- $1520.00-2500.00
- TargetMol Chemicals Inc.
