(S)-3-((7-((difluoromethyl)sulfonyl)-2,2-difluoro-1-hydroxy-2,3-dihydro-1H-inden-4-yl)oxy)-5-fluorobenzonitrile
- CAS No.
- 1672662-14-4
- Chemical Name:
- (S)-3-((7-((difluoromethyl)sulfonyl)-2,2-difluoro-1-hydroxy-2,3-dihydro-1H-inden-4-yl)oxy)-5-fluorobenzonitrile
- Synonyms
- PT2339;PT2399 ，S8351;PT2399, 10 mM in DMSO;PT2399;PT 2399;PT-2399;3-[(1S)-7-(Difluoromethylsulfonyl)-2,2-difluoro-1-hydroxy-indan-4-yl]oxy-5-fluoro-benzonitrile;Hypoxia-inducible factors,Inhibitor,PT2399,inhibit,HIF-PH,HIF/HIF Prolyl-Hydroxylase,HIFs,PT-2399,PT 2399;(S)-3-((7-((difluoromethyl)sulfonyl)-2,2-difluoro-1-hydroxy-2,3-dihydro-1H-inden-4-yl)oxy)-5-fluorobenzonitrile;Benzonitrile, 3-[[(1S)-7-[(difluoromethyl)sulfonyl]-2,2-difluoro-2,3-dihydro-1-hydroxy-1H-inden-4-yl]oxy]-5-fluoro-
- CBNumber:
- CB63376911
- Molecular Formula:
- C17H10F5NO4S
- Molecular Weight:
- 419.32
- MDL Number:
- MFCD32062659
- MOL File:
- 1672662-14-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
(S)-3-((7-((difluoromethyl)sulfonyl)-2,2-difluoro-1-hydroxy-2,3-dihydro-1H-inden-4-yl)oxy)-5-fluorobenzonitrile Properties
| Boiling point | 516.0±50.0 °C(Predicted) |
|---|---|
| Density | 1+-.0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C, stored under nitrogen |
| solubility | DMSO : ≥ 200 mg/mL (476.96 mM) |
| pka | 11.30±0.40(Predicted) |
| form | Solid |
| color | White to off-white |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319 |
| Precautionary statements | P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330 |
(S)-3-((7-((difluoromethyl)sulfonyl)-2,2-difluoro-1-hydroxy-2,3-dihydro-1H-inden-4-yl)oxy)-5-fluorobenzonitrile price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | XRC66214 | PT2399 | 1672662-14-4 | 10mg | $986.4 | 2026-06-05 | Buy |
| Biosynth | XRC66214 | PT2399 | 1672662-14-4 | 25mg | $1608.25 | 2026-06-05 | Buy |
| Biosynth | XRC66214 | PT2399 | 1672662-14-4 | 50mg | $2572.5 | 2026-06-05 | Buy |
| ChemScene | CS-0030117 | PT2399 99.96% | 1672662-14-4 | 5mg | $325 | 2026-06-04 | Buy |
| ChemScene | CS-0030117 | PT2399 99.96% | 1672662-14-4 | 10mg | $487 | 2026-06-04 | Buy |
(S)-3-((7-((difluoromethyl)sulfonyl)-2,2-difluoro-1-hydroxy-2,3-dihydro-1H-inden-4-yl)oxy)-5-fluorobenzonitrile Chemical Properties, Uses, Production
Biological Activity
PT2399 is a potent and selective HIF-2α antagonist, which directly binds to HIF-2α PAS B domain with an IC50 of 6 nM. PT2399 displays potent antitumor activity in vivo[1][2][3]. PT2399 (compound 10f) inhibits HIF-2α with an IC50 of 6 nM[3]. PT2399 can bind directly to the HIF-2α PAS B domain, and cripple HIF-2α's ability to bind to Aryl hydrocarbon receptor nuclear translocator (ARNT)[2].PT2399 (20 μM) causes off-target toxicity because it inhibits the proliferation of HIF-2α -/- 786-O cells and other cancer cell lines with undetectable HIF-2α[2]. PT2399 (0.2-2 μM; 0-21 days) inhibits 786-O cells soft agar growth[2].PT2399 represses various HIF target genes in 786-O VHL-/- ccRCC cells, does not suppress HIF-1α-specific targets such as BNIP3[2]. PT2399 inhibits tumor cell proliferation 3.5 fold in renal cell carcinoma (RCC) bearing mice[1].PT2399 reduces tumor cell density and increases fibrosis in RCC bearing mice[1].PT2399 (100 mg/kg; oral gavage; every 12 hours) is more active than SU 11248, and inhibits tumor growth in several SU 11248-resistant tumors in RCC bearing mice [1].PT2399 directly inhibits HIF-2α causes tumor regression in preclinical models of primary and metastatic pVHL-defective ccRCC in an on-target fashion[2].
References
[1]. Chen W, et al. Targeting renal cell carcinoma with a HIF-2 antagonist. Nature. 2016 Nov 3;539(7627):112-117.[2]. Cho H, et al. On-Target Efficacy of a HIF2α Antagonist in Preclinical Kidney Cancer Models. Nature. Nature. 2016 Nov 3;539(7627):107-111.[3]. Wehn PM, et al. Design and Activity of Specific Hypoxia-Inducible Factor-2α (HIF-2α) Inhibitors for the Treatment of Clear Cell Renal Cell Carcinoma: Discovery of Clinical Candidate (S)-3-((2,2-Difluoro-1-hydroxy-7-(methylsulfonyl)-2,3-dihydro-1 H-inden-4-yl)oxy)-5-fluorobenzonitrile (PT2385). J Med Chem. 2018 Nov 8;61(21):9691-9721.
(S)-3-((7-((difluoromethyl)sulfonyl)-2,2-difluoro-1-hydroxy-2,3-dihydro-1H-inden-4-yl)oxy)-5-fluorobenzonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
(S)-3-((7-((difluoromethyl)sulfonyl)-2,2-difluoro-1-hydroxy-2,3-dihydro-1H-inden-4-yl)oxy)-5-fluorobenzonitrile Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai SuperLan Chemcial Technique Centre | 0-2022843681 15618226720 | chaolaichem@foxmail.com | China | 9996 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8000 | 62 |
| Shanghai Chaolan Chemical Technology Center | QQ：65489617 13301690235 | Sales@ATKchemical.com | China | 9729 | 58 |
| Chuzhou KeMail Chemical Technology Co., Ltd | 0550-5196001 15000891977 | wj520wjxby@126.com | China | 1940 | 55 |
| Shanghai Tube Pharmaceutical Co., Ltd. | 021-54338626 18017892860 | sales@tubepharm.com | China | 2709 | 58 |
| Shanghai zhigan biotechnology co., LTD | zhiqianbio@126.com | China | 19765 | 58 | |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 | sales@sarms4muscle.com | China | 10378 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6378 | 58 |
