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BENZETIMIDE

BENZETIMIDE Structure
BENZETIMIDE structure
CAS No.
21888-98-2
Chemical Name:
BENZETIMIDE
Synonyms
R 16470;BENZETIMIDE;Dexbenzetimide;DEXETIMIDE HCL;(+)-Benzetimide;RSYYBENZETIMIDE;Dextrobenzetimide;(S)-(+)-Dexetimide;BENZETIMIDE USP/EP/BP;(+)-DEXETIMIDE HYDROCHLORIDE
CBNumber:
CB6343451
Molecular Formula:
C23H26N2O2
Molecular Weight:
362.46
MDL Number:
MFCD00242706
MOL File:
21888-98-2.mol
MSDS File:
SDS
Last updated:2026-05-11 16:31:51
Product description Number Pack Size Price
Dexetimide 99.94% CS-0026226 5mg $195
Dexetimide 99.94% CS-0026226 10mg $303
Dexetimide 99.94% CS-0026226 25mg $617
Dexetimide 99.94% CS-0026226 50mg $997
Dexetimide 99.94% CS-0026226 100mg $1603
Request For Quotation

BENZETIMIDE Properties

Melting point 181-183°
alpha D20 +125° (chloroform)
Boiling point 543.9±50.0 °C(Predicted)
Density 1.178±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO: ≥ 100 mg/mL (275.89 mM)
pka 11.20±0.40(Predicted)
form Solid
color White to off-white
FDA UNII 43477QYX3D

SAFETY

Risk and Safety Statements

RIDADR  3249
HazardClass  6.1(b)
PackingGroup  III

BENZETIMIDE price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0026226 Dexetimide 99.94% 21888-98-2 5mg $195 2026-06-04 Buy
ChemScene CS-0026226 Dexetimide 99.94% 21888-98-2 10mg $303 2026-06-04 Buy
ChemScene CS-0026226 Dexetimide 99.94% 21888-98-2 25mg $617 2026-06-04 Buy
ChemScene CS-0026226 Dexetimide 99.94% 21888-98-2 50mg $997 2026-06-04 Buy
ChemScene CS-0026226 Dexetimide 99.94% 21888-98-2 100mg $1603 2026-06-04 Buy
Product number Packaging Price Buy
CS-0026226 5mg $195 Buy
CS-0026226 10mg $303 Buy
CS-0026226 25mg $617 Buy
CS-0026226 50mg $997 Buy
CS-0026226 100mg $1603 Buy

BENZETIMIDE Chemical Properties,Uses,Production

Originator

Tremblex,Brocades,Italy,1981

Uses

Anticholinergic.

Definition

ChEBI: Dexetimide is a member of piperidines.

Manufacturing Process

400 parts glacial acetic acid are cooled to 10°C to 20°C. Then there are added first dropwise 300 parts concentrated sulfuric acid followed by portionwise addition of 50 parts dl-1-benzyl-4-(1,3-dicyano-1-phenylpropyl)-piperidine hydrochloride at the same temperature. After the addition is complete, the whole is heated to 125°C in the course of 15 to 20 minutes. This temperature is then maintained for 10 minutes. After cooling, the reaction mixture is poured into ice, alkalized with NH4OH at a temperature < 20°C and extracted with chloroform. The chloroform layer is first washed twice with a K2CO3 5% solution, and then washed twice with water, dried over MgSO4, filtered and evaporated. The residue is dissolved in a mixture of 320 parts acetone and 600 parts diisopropylether, filtered and HCl gas is introduced into the filtrate. The solid hydrochloride is filtered off and dried, to yield 43 parts less pure lbenzyl-4-(2.6-dioxo-3-phenyl-3-piperidyl)-piperidine hydrochloride, melting point 283°C to 294°C.
A sample of 4 parts is recrystallized from a boiling mixture of 80 parts isopropanol, 40 parts methanol and 500 parts water. The whole is filtered and after cooling the filtrate overnight at -20°C, 1-benzyl-4-(2,6-dioxo-3phenyl-3- piperidyl)-piperidine hydrochloride is obtained, melting point 299°C to 301.5°C, as a white amorphous powder.
The dextro-isomer may be separated via the dextro-camphorsulfonate of the base.

Therapeutic Function

Anticholinergic (ophthalmic)

BENZETIMIDE synthesis

14051-33-3
21888-98-2
21888-99-3
Synthesis of BENZETIMIDE from 3-(1-benzyl-4-piperidyl)-3-phenyl-piperidine-2,6-dione

BENZETIMIDE Preparation Products And Raw materials

Raw materials

Hydrochloric acid

Preparation Products

BENZETIMIDE Suppliers

Global( 39)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
Career Henan Chemica Co 		+86-0371-86658258 +86-13203830695 laboratory@coreychem.com China 30203 58
BOC Sciences 		16314854226; +8616314854226 inquiry@bocsci.com United States 19852 58
Shaanxi Didu New Materials Co. Ltd 		+86-86-17392712779 +86-13289823923 1090@dideu.com China 8651 58
TargetMol Chemicals Inc. 		+1-781-999-5354; support@targetmol.com United States 38999 58
GIHI CHEMICALS CO.,LIMITED 		+86-571-86217390; +8618058761490 info@gihichemicals.com China 49859 58
Shanghai Acmec Biochemical Technology Co., Ltd. 		+86-18621343501 product@acmec-e.com China 33301 58
Beijing Solarbio Science & Tecnology Co., Ltd. 17801761073 18101056239 3193328036@qq.com China 29554 68
Jinan Ruisi Pharmaceutical Technology Co., LTD 0531-0531-69900633 19963472814 changyuan20@163.com China 5560 58
Beijing Jin Ming Biotechnology Co., Ltd. 010-60605840 psaitong@jm-bio.com China 27066 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
Career Henan Chemica Co 		58
BOC Sciences 		58
Shaanxi Didu New Materials Co. Ltd 		58
TargetMol Chemicals Inc. 		58
GIHI CHEMICALS CO.,LIMITED 		58
Shanghai Acmec Biochemical Technology Co., Ltd. 		58
Beijing Solarbio Science & Tecnology Co., Ltd. 68
Jinan Ruisi Pharmaceutical Technology Co., LTD 58
Beijing Jin Ming Biotechnology Co., Ltd. 58

View Lastest Price from BENZETIMIDE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Dexetimide pictures 2026-05-11 Dexetimide
21888-98-2
 $37.00-57.00 10g TargetMol Chemicals Inc.
  • Dexetimide pictures
  • Dexetimide
    21888-98-2
  • $37.00-57.00
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[3,4'-Bipiperidine]-2,6-dione, 3-phenyl-1'-(phenylmethyl)-, (S)- Dexbenzetimide Dextrobenzetimide DEXETIMIDE HCL (+)-DEXETIMIDE HYDROCHLORIDE BENZETIMIDE 3-PHENYL-1'-(PHENYLMETHYL)-[3,4'-BIPIPERIDINE]-2,6-DIONE HYDROCHLORIDE R 16470 (S)-(+)-3-PHENYL-1'-(PHENYLMETHYL)-[3,4'-BIPIPERIDINE]-2,6-DIONE, HCL S(+)-DEXETIMIDE HYDROCHLORIDE S(+)-DEXETIMIDE HYDROCHLORIDE (R16470) H IGH AFFINITY MUSCARI (3S)-3-(1-Benzyl-4-piperidyl)-3-phenylpiperidine-2,6-dione (S)-(+)-Dexetimide [3,4'-Bipiperidine]-2,6-dione, 3-phenyl-1'-(phenylmethyl)-, (3S)- BENZETIMIDE USP/EP/BP (+)-Benzetimide RSYYBENZETIMIDE 21888-98-2 21888-96-9