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3,4-Dimethoxyacetophenone

3,4-Dimethoxyacetophenone structure

CAS No.: 1131-62-0

Chemical Name:: 3,4-Dimethoxyacetophenone

Synonyms: 1-(3,4-DIMETHOXYPHENYL)ETHAN-1-ONE;ACETOVERATRONE;3,4-Dimethoxyacetophenon;3,4-Dimethoxyacetoph;Dimethoxyacetophenone;1-(3,4-DIMETHOXYPHENYL)-ETHANONE;KML-86;KML-118;AKOS 220-35;ACETOVERATRON

CBNumber:: CB6350428

Molecular Formula:: C10H12O3

Molecular Weight:: 180.2

MDL Number:: MFCD00008737

MOL File:: 1131-62-0.mol

MSDS File:: SDS

Last updated:2026-01-13 11:23:55

Product description	Number	Pack Size	Price
3′,4′-Dimethoxyacetophenone 98%	156639	25g	$64.1
3′,4′-Dimethoxyacetophenone 98%	156639	100g	$205
3',4'-Dimethoxyacetophenone >98.0%(GC)	D1878	25g	$48
3',4'-Dimethoxyacetophenone >98.0%(GC)	D1878	100g	$122
3',4'-Dimethoxyacetophenone >98.0%(GC)	D1878	500g	$375
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3,4-Dimethoxyacetophenone Properties

Melting point	47-54 °C(lit.)
Boiling point	286-288 °C(lit.)
Density	1.1272 (rough estimate)
refractive index	1.5224 (estimate)
Flash point	>230 °F
storage temp.	Sealed in dry,Room Temperature
solubility	hot water: soluble
form	Crystalline Powder
color	Yellow to beige
Odor	at 10.00 % in dipropylene glycol. sweet woody floral
Odor Type	woody
Water Solubility	SOLUBLE IN HOT WATER
BRN	781213
InChI	1S/C10H12O3/c1-7(11)8-4-5-9(12-2)10(6-8)13-3/h4-6H,1-3H3
InChIKey	IQZLUWLMQNGTIW-UHFFFAOYSA-N
SMILES	COc1ccc(cc1OC)C(C)=O
LogP	1.822 (est)
CAS DataBase Reference	1131-62-0(CAS DataBase Reference)
FDA UNII	5RV6436S8A
NIST Chemistry Reference	Ethanone, 1-(3,4-dimethoxyphenyl)-(1131-62-0)
EPA Substance Registry System	Ethanone, 1-(3,4-dimethoxyphenyl)- (1131-62-0)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P280-P271

PPE

Eyeshields, Gloves, type N95 (US)

Hazard Codes

Safety Statements

24/25

WGK Germany

TSCA

TSCA listed

HS Code

29145000

Storage Class

11 - Combustible Solids

NFPA 704

	1
2		0

3,4-Dimethoxyacetophenone price More Price(32)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	156639	3′,4′-Dimethoxyacetophenone 98%	1131-62-0	25g	$64.1	2025-07-31	Buy
Sigma-Aldrich	156639	3′,4′-Dimethoxyacetophenone 98%	1131-62-0	100g	$205	2025-07-31	Buy
TCI Chemical	D1878	3',4'-Dimethoxyacetophenone >98.0%(GC)	1131-62-0	25g	$48	2025-07-31	Buy
TCI Chemical	D1878	3',4'-Dimethoxyacetophenone >98.0%(GC)	1131-62-0	100g	$122	2025-07-31	Buy
TCI Chemical	D1878	3',4'-Dimethoxyacetophenone >98.0%(GC)	1131-62-0	500g	$375	2025-07-31	Buy

Product number	Packaging	Price	Buy
156639	25g	$64.1	Buy
156639	100g	$205	Buy
D1878	25g	$48	Buy
D1878	100g	$122	Buy
D1878	500g	$375	Buy

3,4-Dimethoxyacetophenone Chemical Properties,Uses,Production

Synthesis

To a stirred mixture of 3´,4´-dihydroxyacetophenone (100 mg, 0.66 mmol) and anhydrous K2CO3 (5 g, 36 mmol) in dry acetone (10 mL) was added MeI (1 mL, 16 mmol). The mixture was heated at reflflux for 45 min, cooled to room temperature, fifiltered, and evaporated under reduced pressure. The residue was dissolved in CH2Cl2, washed with 2 portions of water, dried over anhydrous Na2SO4, and evaporated under reduced pressure. The product was purifified by flflash chromatography (silica, hexane/EtOAc 4:1, v/v). Removal of the solvent gave a 93% yield of the product, 3´,4´-dimethoxyacetophenone (110 mg, 0.61 mmol). Reference: Khatib, S.; Nerya, O.; Musa, R.; Shmuel, M.; Tamir, S.; Vaya, J. Bioorg. Med. Chem. 2005, 13, 433−441.

Chemical Properties

yellow to beige crystalline powder

Uses

3',4'-Dimethoxyacetophenone is used as Catalytic agent; Petrochemical additive. It is also used in agrochemical, pharmaceutical and dyestuff field.

Definition

ChEBI: A member of the class of acetophenones that is acetophenone substituted by methoxy groups at positions 3' and 4' respectively.

Preparation

Obtained by reaction of dimethyl sulfate with acetoguaiacone in the presence of sodium hydroxide in ethanol, first at 50°, then at reflux for 1 h (78%).

Synthesis Reference(s)

Tetrahedron Letters, 36, p. 409, 1995 DOI: 10.1016/0040-4039(94)02221-V

References

[1] G. Hawkes. “An unusual anodic methoxylation: 3,4-dimethoxyacetophenone.” Tetrahedron Letters 33 1 (1992): 8133–8136.
[2] P. Kuzmi?, M. Soucek. “Substituent effects in aromatic photochemistry. UV irradiation of 3,4-dimethoxybenzonitrile and 3,4-dimethoxyacetophenone in the presence of inorganic anions.” Collection of Czechoslovak Chemical Communications 52 1 (1987): 980–988.
[3] Virginia Vetere . “Study of the racemic and enantioselective hydrogenation of acetophenone and 3,4-dimethoxyacetophenone using platinum-based organotin catalysts.” Catalysis Today 107 (2005): Pages 266-272.

3,4-Dimethoxyacetophenone Preparation Products And Raw materials

Raw materials

Preparation Products

4-Aminoveratrole 1,2-DIMETHOXY-4-ETHYLBENZENE 4-chloro-6,7-dimethoxyquinoline 2'-HYDROXY-3',4'-DIMETHOXYACETOPHENONE veratrylglycerol-beta-guaiacyl ether

2'-AMINO-4',5'-DIMETHOXYACETOPHENONE 1-(4,5-DIMETHOXY-2-NITRO-PHENYL)-ETHANONE 4-METHOXY-3-HYDROXYACETOPHENONE 2,6-Dimethoxyphenol 1,2-Dimethoxybenzene

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3,4-Dimethoxyacetophenone Suppliers

Global( 396)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Suzhou Nordica Biopharma CO.,LTD	+86-18136148818 +86-18567353071	3537297702@qq.com	China	299	58
SINO HIGH(CHINA)CO.,LTD.	+86-2558392388 +86-13914336446	chang@sinohighchem.com	China	34	58
Hebei Chuanghai Biotechnology Co., Ltd	+8615350571055	Sibel@chuanghaibio.com	China	8753	58
Shaanxi Dideu Medichem Co. Ltd	+86-29-81148696 +86-17392712697	1022@dideu.com	China	3995	58
Hebei Yanxi Chemical Co., Ltd.	+8618531123677	faithe@yan-xi.com	China	5853	58
Hebei Chuanghai Biotechnology Co,.LTD	+86-13131129325	sales1@chuanghaibio.com	China	5242	58
Firsky International Trade (Wuhan) Co., Ltd	+8615387054039	admin@firsky-cn.com	China	427	58
Hebei Yiduo Import and Export Co., Ltd.		joycedemei1505@outlook.com	China	215	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29735	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21599	55

Supplier	Advantage
Suzhou Nordica Biopharma CO.,LTD	58
SINO HIGH(CHINA)CO.,LTD.	58
Hebei Chuanghai Biotechnology Co., Ltd	58
Shaanxi Dideu Medichem Co. Ltd	58
Hebei Yanxi Chemical Co., Ltd.	58
Hebei Chuanghai Biotechnology Co,.LTD	58
Firsky International Trade (Wuhan) Co., Ltd	58
Hebei Yiduo Import and Export Co., Ltd.	58
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55

View Lastest Price from 3,4-Dimethoxyacetophenone manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-01-05	3,4-Dimethoxyacetophenone 1131-62-0	US $1.00 / KG	1KG	99%	10 mt	Hebei Chuanghai Biotechnology Co., Ltd
2025-12-24	3,4-Dimethoxyacetophenone 1131-62-0	US $0.00-0.00 / KG	1KG	99.0%	5000KG	Shaanxi Dideu Medichem Co. Ltd
2025-06-20	3,4-Dimethoxyacetophenone 1131-62-0	US $0.00-0.00 / KG	25KG	99%	50MT/month	Hebei Yanxi Chemical Co., Ltd.

3,4-Dimethoxyacetophenone
1131-62-0
US $1.00 / KG
99%
Hebei Chuanghai Biotechnology Co., Ltd

3,4-Dimethoxyacetophenone
1131-62-0
US $0.00-0.00 / KG
99.0%
Shaanxi Dideu Medichem Co. Ltd

3,4-Dimethoxyacetophenone
1131-62-0
US $0.00-0.00 / KG
99%
Hebei Yanxi Chemical Co., Ltd.

3,4-Dimethoxyacetophenone Spectrum

3,4-Dimethoxyacetophenone(1131-62-0)MS 3,4-Dimethoxyacetophenone(1131-62-0)¹HNMR 3,4-Dimethoxyacetophenone(1131-62-0)¹³CNMR 3,4-Dimethoxyacetophenone(1131-62-0)IR1 3,4-Dimethoxyacetophenone(1131-62-0)IR2 3,4-Dimethoxyacetophenone(1131-62-0)Raman

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Dimethoxyacetophenone 3,4-Dimethoxyacetoph 3,4-DIMETHOXYACETOPHENONE FOR SYNTHESIS 3,4-Dimethoxyacetophenone≥ 99% (GC) 3,4-DIMETHOXYACETOPHENONE 3,4-dimethoxyacetophenone (acetoveratrone) 3',4'-Dimethoxyacetophenone 1-(3,4-Dimethoxyphenyl)ethan-1-one 3,4-Dimethoxyacetophenone 3,4-dimethoxyacetophene 1-(3,4-Dimethoxyphenyle)ethane-1-one Acetyl veratrole 3' 4'-DIMETHOXYACETOPHENONE 98+% ACETYL VERATROL ACETOVERATRONE(RG) 1-(3,4-dimethoxyphenyl)-ethanon LABOTEST-BB LT00000195 3,4-Dimethoxyacetophenon 3,4-Dimethoxyphenyl methyl ketone 3,4-Dimethoxyphenylmethylketone Acetophenone, 3',4'-dimethoxy- Acetophenone,3’,4’-dimethoxy- Ethanone,1-(3,4-dimethoxyphenyl)- Methyl3,4-dimethoxyphenylketone 1-(3,4-DIMETHOXYPHENYL)-ETHANONE 1-(3,4-DIMETHOXYPHENYL)-ETHANO 1-(3,4-DIMETHOXYPHENYL)ETHAN-1-ONE ACETOVERATRON ACETOVERATRONE AKOS 220-35 AKOS BBS-00003221 4-ACETYLPYROCATECHOL DIMETHYL ETHER 4-ACETYLVERATROLE 3',4'-Dimethoxyacetophenone> KML-86 3',4'-Dimethoxyacetophenone1131-62-0 KML-118 Compound PDK0029 3,4-DChemicalbookIMETHOXYACETOPHENONE 3',4'-Dimethoxyacetophenone 3',4'-Dimethoxyacetophenone, 97% 1131-62-0 1131-62-7 1132-62-0 KETONE Ketones Organic Building Blocks Building Blocks C10 Carbonyl Compounds Alphabetical Listings C-D Flavors and Fragrances C10 Carbonyl Compounds Ketones Benzene derivatives Aromatic Acetophenones & Derivatives (substituted) 1131-62-0