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5-Chloro-2-(methylamino)benzophenone

5-Chloro-2-(methylamino)benzophenone structure

CAS No.: 1022-13-5

Chemical Name:: 5-Chloro-2-(methylamino)benzophenone

Synonyms: Ro 5-4365;Methyl-aMino ketone;Diazepam Impurity D;Diazepam Impurity C;Diazepam Impurity A;Diazepam Impurity 9;Diazapam Impurity D;TeMazepaM IMpurity A;Diazepam benzophenone;Diazepam EP impurity D

CBNumber:: CB6355175

Molecular Formula:: C14H12ClNO

Molecular Weight:: 245.7

MDL Number:: MFCD00008284

MOL File:: 1022-13-5.mol

MSDS File:: SDS

Last updated:2026-01-13 11:24:13

Product description	Number	Pack Size	Price
Temazepam Related Compound A United States Pharmacopeia (USP) Reference Standard	1644319	15mg	$680
Diazepam Related Compound A United States Pharmacopeia (USP) Reference Standard	1185020	25mg	$1300
5-Chloro-2-(methylamino)benzophenone >98.0%(GC)	C2281	25g	$72
5-Chloro-2-(methylamino)benzophenone 99%	191353	10g	$41.23
5-Chloro-2-(methylamino)benzophenone	C369020	10g	$70
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5-Chloro-2-(methylamino)benzophenone Properties

Melting point	93-95 °C (lit.)
Boiling point	421.9±35.0 °C(Predicted)
Density	1.234±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	Chloroform (Slightly), Dichloromethane (Slightly), DMSO (Slightly), Methanol (Very Slightly)
pka	pKa 1.45±0.04(7% EtOH in H2O,t =25,0.02 to 0.40M in HCl) (Uncertain)
form	Solid
color	Light Yellow to Yellow
BRN	882187
Stability	Stable. Incompatible with strong oxidizing agents.
InChI	InChI=1S/C14H12ClNO/c1-16-13-8-7-11(15)9-12(13)14(17)10-5-3-2-4-6-10/h2-9,16H,1H3
InChIKey	WPNMLCMTDCANOZ-UHFFFAOYSA-N
SMILES	C(C1=CC(Cl)=CC=C1NC)(C1=CC=CC=C1)=O
CAS DataBase Reference	1022-13-5(CAS DataBase Reference)
EWG's Food Scores	1
FDA UNII	D4GD5770PI
NIST Chemistry Reference	Methanone, [5-chloro-2-(methylamino)phenyl]phenyl-(1022-13-5)
EPA Substance Registry System	Methanone, [5-chloro-2-(methylamino)phenyl]phenyl- (1022-13-5)
UNSPSC Code	41116107
NACRES	NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P305+P351+P338

target organs

Respiratory system

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-37/39

WGK Germany

RTECS

DJ0414000

TSCA

TSCA listed

HS Code

2933999552

Storage Class

11 - Combustible Solids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

NFPA 704

	0
1		0

5-Chloro-2-(methylamino)benzophenone price More Price(18)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	1644319	Temazepam Related Compound A United States Pharmacopeia (USP) Reference Standard	1022-13-5	15mg	$680	2025-07-31	Buy
Sigma-Aldrich	1185020	Diazepam Related Compound A United States Pharmacopeia (USP) Reference Standard	1022-13-5	25mg	$1300	2025-07-31	Buy
TCI Chemical	C2281	5-Chloro-2-(methylamino)benzophenone >98.0%(GC)	1022-13-5	25g	$72	2025-07-31	Buy
Sigma-Aldrich	191353	5-Chloro-2-(methylamino)benzophenone 99%	1022-13-5	10g	$41.23	2025-07-31	Buy
TRC	C369020	5-Chloro-2-(methylamino)benzophenone	1022-13-5	10g	$70	2021-12-16	Buy

Product number	Packaging	Price	Buy
1644319	15mg	$680	Buy
1185020	25mg	$1300	Buy
C2281	25g	$72	Buy
191353	10g	$41.23	Buy
C369020	10g	$70	Buy

5-Chloro-2-(methylamino)benzophenone Chemical Properties,Uses,Production

Chemical Properties

solid

Uses

5-Chloro-2-(methylamino)benzophenone is an impurity of 1,4- Temazepam (T017200) as well as a decompoition product of Diazepam and other 1,4-benzodiazepine derivatives.

Uses

5-Chloro-2-(methylamino)benzophenone was used in the simultaneous determination of hydrazine and benzylhydrazine in isocarboxazid raw material and tablet formulations by gas chromatography.

Synthesis

Weigh 231g of 2-amino-5-chlorobenzophenone, 900g of dimethyl carbonate and 70g of NaY molecular sieves with high silica-aluminum ratio and small grain NaY molecular sieves in a reaction flask. Stirred and heated up to 80C. After holding the reaction for 8h, a sample was taken and analyzed, and the content of raw material 2-amino-5-chlorobenzophenone in the reaction solution was measured to be 0.2%, and the reaction could be stopped.

Pass water cooling to room temperature, filtration to remove the catalyst, the filtrate is transferred to a reduced-pressure steaming flask, the unreacted dimethyl carbonate evaporated under reduced pressure, the residue is recrystallized with ethanol to obtain yellow needle crystals, that is, 221g of 2-methylamino-5-chlorobenzophenone, 90.2% yield, melting point of 94.0-95.1 C, HPLC purity of 98.9%.

5-Chloro-2-(methylamino)benzophenone Preparation Products And Raw materials

Raw materials

2-Furoic acid Isoxazole Dimethyl sulfate

Preparation Products

N-(2-benzoyl-4-chlorophenyl)-2-bromo-N-methylacetamide

5-Chloro-2-(methylamino)benzophenone Suppliers

Global( 365)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Chuanghai Biotechnology Co,.LTD	+86-13131129325	sales1@chuanghaibio.com	China	5242	58
Hebei Chuanghai Biotechnology Co., Ltd	+8615531151365	mina@chuanghaibio.com	China	18126	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20128	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29735	60
Dalian Richfortune Chemicals Co., Ltd	+86-86-411-84820922 +86-8613904096939	sales@richfortunechem.com	China	305	57
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21597	55
Tianjin Zhongxin Chemtech Co., Ltd.	86-22-66880623 +8618622897568	sales@tjzxchem.com	China	572	58
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29831	58
Jinan Finer Chemical Co., Ltd	+86-531-88989536 +86-15508631887	sales@finerchem.com	China	2950	58
Xiamen AmoyChem Co., Ltd	+86-86-5926051114 +8615060885618	sales@amoychem.com	China	6369	58

Supplier	Advantage
Hebei Chuanghai Biotechnology Co,.LTD	58
Hebei Chuanghai Biotechnology Co., Ltd	58
Henan Fengda Chemical Co., Ltd	58
Capot Chemical Co.,Ltd.	60
Dalian Richfortune Chemicals Co., Ltd	57
Henan Tianfu Chemical Co.,Ltd.	55
Tianjin Zhongxin Chemtech Co., Ltd.	58
career henan chemical co	58
Jinan Finer Chemical Co., Ltd	58
Xiamen AmoyChem Co., Ltd	58

View Lastest Price from 5-Chloro-2-(methylamino)benzophenone manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-12-29	5-Chloro-2-(methylamino)benzophenone 1022-13-5	US $0.00-0.00 / kg	1kg	98%	1000kg	Shaanxi Dideu New Materials Co. Ltd
2025-09-25	5-Chloro-2-(methylamino)benzophenone 1022-13-5	US $10.00-2.00 / KG	1KG	99%	g-kg-tons, free sample is available	Henan Fengda Chemical Co., Ltd
2025-06-27	5-Chloro-2-(methylamino)benzophenone 1022-13-5	US $0.00-0.00 / KG	1KG	99%	500000kg	Hebei Chuanghai Biotechnology Co., Ltd

5-Chloro-2-(methylamino)benzophenone
1022-13-5
US $0.00-0.00 / kg
98%
Shaanxi Dideu New Materials Co. Ltd

5-Chloro-2-(methylamino)benzophenone
1022-13-5
US $10.00-2.00 / KG
99%
Henan Fengda Chemical Co., Ltd

5-Chloro-2-(methylamino)benzophenone
1022-13-5
US $0.00-0.00 / KG
99%
Hebei Chuanghai Biotechnology Co., Ltd

5-Chloro-2-(methylamino)benzophenone Spectrum

5-Chloro-2-(methylamino)benzophenone(1022-13-5)¹HNMR

1022-13-5(5-Chloro-2-(methylamino)benzophenone)Related Search:

2-Cyclopropylmethylamino-5-chlorobenzophenone 5-Chloro-2-(methylamino)benzophenone 2-Chloro-N-[4-chloro-2-(2-chlorobenzoyl)phenyl]acetamide 2-Bromo-N-[4-chloro-2-(2-chlorobenzoyl)phenyl]acetamide 2'-BENZOYL-2,4'-DICHLOROACETANILIDE

2-BROMOACETAMIDO-5-CHLOROBENZOPHENONE N-(2-BENZOYL-4-CHLOROPHENYL)FORMAMIDE DIAZEPAM IMP. D (EP): [5-CHLORO-2-(METHYLAMINO)PHENYL]PHENYLMETHANONE (5-CHLORO-2-(METHYLAMINO)BENZOPHENONE) TEMAZEPAM IMP. A (EP): [5-CHLORO-2-(METHYLAMINO)PHENYL]PHENYLMETHANONE(5-CHLORO-2-(METHYLAMINO)BENZOPHENONE) N3-[4-CHLORO-2-(2-CHLOROBENZOYL)PHENYL]-2-CHLORONICOTINAMIDE

AURORA 3316 (2-[(2-BROMOETHYL)AMINO]-5-CHLOROPHENYL)(PHENYL)METHANONE AURORA 9232 DIETHYL 2-[(2-BENZOYL-4-CHLOROANILINO)METHYLENE]MALONATE 10-BUTYL-2-CHLORO-9(10H)-ACRIDONE

SALOR-INT L449652-1EA N-(2-BENZOYL-4-CHLOROPHENYL)-2,2,2-TRIFLUOROACETAMIDE N-(2-BENZOYL-4-CHLOROPHENYL)-2-THIOPHENECARBOXAMIDE

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(5-chloro-2-(methylamino)phenyl)phenyl-methanon DiazepaM Related CoMpound A TeMazepaM Related CoMpound A Chloro-2-(MethylaMino)benzoph Diazepam Impurity A Diazepam Impurity C Diazepam Impurity D Diazepam EP impurity D Diazepam Impurity. D (EP) 2-METHYLAMINO-5-CHLORO BENZOPHENONE 99.0+% Methyl-aMino ketone Diazepam Related Compound A (25 mg) (2-methylamino-5-chlorobenzophenone) Temazepam Related Compound A (15 mg) (5-chloro-2-methylaminobenzophenone) Ro 5-4365 TeMazepaM IMpurity A Diazepam Impurity 4（Diazepam EP Impurity D） [5-chloro-2-(methylamino)phenyl]phenyl-methanon [5-Chloro-2-(methylamino)phenyl]phenylmethanone 5-chloro-2-(methylamino)-benzophenon Benzophenone, 2-acetamido-5-chloro- Benzophenone, 5-chloro-2-(methylamino)- Diazepam benzophenone Diazepam, acid hydrolyzed Methanone, [5-chloro-2-(methylamino)phenyl]phenyl- 2-METHYLAMINO-5-CHLORO BENZOPHENONE 5-CHLORO-2-(METHYLAMINO)BENZOPHENONE 5-CHLORO-2-(METHYLAMINO)BENZOPHENONE, 99 % 5-Chloro-2-(methylamino)benzophenone > Diazepam Impurity 9 Temazepam EP Impurity A Temazepam Related Compound A (5-chloro-2-methylaminobenzophenone) (1644319) Diazepam Related Compound A (2-methylamino-5-chlorobenzophenone) (1185020) Diazapam Impurity D Diazepam USP Related Compound A Temazepam USP Related Compound A 5-Chloro-2-(methylamino)benzophenone, ≥ 98.0% 5-Chloro-2-(methylamino)benzophenone in methanol 5-Chloro-2-(methylamino)phenyl]-phenylmethanone (5-Chloro-2-(methylamino)benzophenone) 5-Chloro-2-methylaminobenzophenone RS Temazepam EP Impurity A (Diazepam EP Impurity D, Diazepam USP Related Compound A) 1022-13-5 CH3NHC6H3ClCOC6H5 C14H12NOCl C14H12ClNO AMINE Carbonyl Compounds C13 to C14 Building Blocks Ketones Organic Building Blocks API intermediates C13 to C14 Carbonyl Compounds Ketones Aromatic Benzophenones & Derivatives (substituted) K00001 john's