ChemicalBook >> CAS DataBase List >>AZTSBAWJROLRIQ-LESCRADOSA-N
AZTSBAWJROLRIQ-LESCRADOSA-N
- CAS No.
- 135383-55-0
- Chemical Name:
- AZTSBAWJROLRIQ-LESCRADOSA-N
- Synonyms
- AZTSBAWJROLRIQ-LESCRADOSA-N;Monomethyl auristatin E intermediate-7;(3R,4S,5S)-tert-Butyl 4-(((benzyloxy)carbonyl)amino)-3-hydroxy-5-methylheptanoate;tert-butyl (3R,4S,5S)-3-hydroxy-5-methyl-4-(phenylmethoxycarbonylamino)heptanoate;tert-butyl (3R,4S,5S)-4-(((benzyloxy)carbonyl)amino)-3-hydroxy-5-methylheptanoate;Heptanoic acid, 3-hydroxy-5-methyl-4-[[(phenylmethoxy)carbonyl]amino]-, 1,1-dimethylethyl ester, [3R-(3R*,4S*,5S*)]- (9CI)
- CBNumber:
- CB63586745
- Molecular Formula:
- C20H31NO5
- Molecular Weight:
- 365.46
- MDL Number:
- MFCD28386970
- MOL File:
- 135383-55-0.mol
- MSDS File:
- SDS
Last updated:2025-04-18 09:52:30
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H301 |
| Precautionary statements | P264-P270-P301+P310-P321-P330-P405-P501 |
AZTSBAWJROLRIQ-LESCRADOSA-N Chemical Properties,Uses,Production
Uses
Monomethyl auristatin E intermediate-7 is an intermediate reagent in the synthesis of Monomethyl auristatin E (HY-15162). Monomethyl auristatin E (MMAE) is a microtubule/tubulin inhibitor with anticancer activity. MMAE is widely used as the cytotoxic component (ADC Cytotoxin) of antibody-drug conjugates (ADCs)[1].
References
[1] Lisa Buckel, et al. Tumor radiosensitization by monomethyl auristatin E: mechanism of action and targeted delivery. Cancer Res. 2015 Apr 1;75(7):1376-87. DOI:10.1158/0008-5472.CAN-14-1931
AZTSBAWJROLRIQ-LESCRADOSA-N Preparation Products And Raw materials
AZTSBAWJROLRIQ-LESCRADOSA-N Suppliers
Global( 10)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Changshu New Venture Imp.&Exp. Co.,Ltd. | 0512-52678575 13776233393 | nvchem_deng@163.com | China | 256 | 58 |
| Shanghai Xingui Biotechnology Co., Ltd. | 15121041756 | xingui2022@126.com | China | 9975 | 58 |
| HUNAN CHEMFISH SCIENTIFIC CO.,LTD | +86-0731-85567275 +86-15707487186 | sales05@chemfish.com | China | 7702 | 58 |
| Shanghai Kaiwei Chemical Technology Co., Ltd. | 021-58461859 15821823057 | service@aiviche.com | China | 49312 | 58 |
| Shanghai Haohong Pharmaceutical Co., Ltd. | 400-8210725 4008210725 | malulu@leyan.com | China | 54995 | 58 |
| Changshu New Venture | 13776233393 | janeabc@163.com | China | 227 | 58 |
| Beijing Stronger Science Co., Ltd. | 0531-88924771 15614660963 | elsa.hang@strongerscience.com | China | 10623 | 58 |
| Zibo Biopolar Rongchuang Pharmaceutical Co. Ltd. | 0533-6092686 13371592196 | ddliu@bio-polar.cn | China | 2889 | 58 |
| SHAANXI DIDEU MEDICHEM CO.LTD | 029-029-81123119 17391733320 | 1021@dideu.com | China | 9999 | 58 |
| Jilin Chinese Academy of Sciences-yanshen Technology | 18143011203 | ET-market@chemextension.com | China | 36686 | 58 |
AZTSBAWJROLRIQ-LESCRADOSA-N
(3R,4S,5S)-tert-Butyl 4-(((benzyloxy)carbonyl)amino)-3-hydroxy-5-methylheptanoate
Heptanoic acid, 3-hydroxy-5-methyl-4-[[(phenylmethoxy)carbonyl]amino]-, 1,1-dimethylethyl ester, [3R-(3R*,4S*,5S*)]- (9CI)
tert-butyl (3R,4S,5S)-4-(((benzyloxy)carbonyl)amino)-3-hydroxy-5-methylheptanoate
tert-butyl (3R,4S,5S)-3-hydroxy-5-methyl-4-(phenylmethoxycarbonylamino)heptanoate
Monomethyl auristatin E intermediate-7
135383-55-0
