Tolfenamic acid
- CAS No.
- 13710-19-5
- Chemical Name:
- Tolfenamic acid
- Synonyms
- CLOTAM;gea6414;Tolfedine;Tolfenamic;olfenamicaci;Toxamic acid;Tofenamic acid;TOLFENAMIC ACID;TOLEFNAMIC ACID;Tolfenamic acid CRS
- CBNumber:
- CB6365693
- Molecular Formula:
- C14H12ClNO2
- Molecular Weight:
- 261.7
- MDL Number:
- MFCD00133865
- MOL File:
- 13710-19-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Tolfenamic acid European Pharmacopoeia (EP) Reference Standard | Y0000154 | 100 mg | $241 |
| Tolfenamic acid VETRANAL , analytical standard | 34073 | 100mg | $121 |
| Tolfenamic acid Pharmaceutical Secondary Standard; Certified Reference Material | PHR1629 | 500mg | $82.8 |
| N-(3-Chloro-2-methylphenyl)anthranilic Acid >97.0%(T) | C2064 | 25g | $127 |
| Tolfenamic Acid ≥95% | 70480 | 5g | $47 |
| More product size | |||
| Melting point | 210-214°C |
|---|---|
| Boiling point | 405.4±40.0 °C(Predicted) |
| Density | 1.2037 (rough estimate) |
| refractive index | 1.5270 (estimate) |
| storage temp. | 2-8°C |
| solubility | Practically insoluble in water, soluble in dimethylformamide, sparingly soluble in ethanol and in methylene chloride. It dissolves in dilute solutions of alkali hydroxides. |
| pka | 3.66±0.36(Predicted) |
| form | Solid |
| color | White to Off-White |
| Water Solubility | Soluble in water (slightly), acetone (~10 mg/ml), DMSO (52 mg/ml at 25°C), methanol (~10 mg/ml) and ethanol (50 mg/ml). |
| Merck | 14,9513 |
| Major Application |
forensics and toxicology pharmaceutical (small molecule) |
| InChI | InChI=1S/C14H12ClNO2/c1-9-11(15)6-4-8-12(9)16-13-7-3-2-5-10(13)14(17)18/h2-8,16H,1H3,(H,17,18) |
| InChIKey | YEZNLOUZAIOMLT-UHFFFAOYSA-N |
| SMILES | C(O)(=O)C1=CC=CC=C1NC1=CC=CC(Cl)=C1C |
| CAS DataBase Reference | 13710-19-5(CAS DataBase Reference) |
| FDA UNII | 3G943U18KM |
| NCI Drug Dictionary | tolfenamic acid |
| ATC code | M01AG02 |
| EPA Substance Registry System | Benzoic acid, 2-[(3-chloro-2-methylphenyl)amino]- (13710-19-5) |
| UNSPSC Code | 41116107 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301 | |||||||||
| Precautionary statements | P264-P270-P301+P310-P405-P501 | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Faceshields, Gloves | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22 | |||||||||
| RIDADR | UN 2811 6.1/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | CB2687500 | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29224919 | |||||||||
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
|||||||||
| Hazard Classifications | Acute Tox. 3 Oral | |||||||||
| Limited Quantities | 5.0 L (1.3 gallons) (liquid) or 5.0 kg (11 lbs) (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) | |||||||||
| NFPA 704 |
|
Tolfenamic acid price More Price(44)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | Y0000154 | Tolfenamic acid European Pharmacopoeia (EP) Reference Standard | 13710-19-5 | 100 mg | $241 | 2026-04-30 | Buy |
| Sigma-Aldrich | 34073 | Tolfenamic acid VETRANAL , analytical standard | 13710-19-5 | 100mg | $121 | 2026-04-30 | Buy |
| Sigma-Aldrich | PHR1629 | Tolfenamic acid Pharmaceutical Secondary Standard; Certified Reference Material | 13710-19-5 | 500mg | $82.8 | 2022-05-15 | Buy |
| TCI Chemical | C2064 | N-(3-Chloro-2-methylphenyl)anthranilic Acid >97.0%(T) | 13710-19-5 | 25g | $127 | 2026-04-30 | Buy |
| Cayman Chemical | 70480 | Tolfenamic Acid ≥95% | 13710-19-5 | 5g | $47 | 2026-04-30 | Buy |
Tolfenamic acid Chemical Properties,Uses,Production
Chemical Properties
White Solid
Uses
antiinflammatory, analgesia
Uses
Amidated GRF fragment equipotent to GRF in release of somatotropin from anterior pituitary
Uses
A non steroidal anti-inflammatory agent found to inhibit COX-2 isoenzymes
Uses
Tolfenamic acid is a non-steroidal anti-inflammatory agent. It interferes with synthesis of β-amyloid precursor protein, and thus Aβ peptides, by promoting degradation of an essential transcription factor. It inhibits fMLP- and A23187-induced Ca2+ influx in human PMNL with an IC50 value of approximately 20 μM.
Uses
Non-steroidal anti-inflammatory drugs (NSAIDs).
Definition
ChEBI: An aminobenzoic acid that is anthranilic acid in which one of the hydrogens attached to the nitrogen is replaced by a 3-chloro-2-methylphenyl group. Tolfenamic acid is used specifically for relieving the pain of migraine. It also shows anticancer activity.
General Description
Tolfenamic Acid is an anthranilic acid derivative and a non-steroidal anti-inflammatory drug (NSAID). Its applications in treating pancreatic, esophageal, colorectal and lung cancer is being investigated.
Biochem/physiol Actions
Non-steroidal anti-inflammatory agent. Interferes with synthesis of β-amyloid precursor protein, and thus Aβ peptides, by promoting degradation of an essential transcription factor.
Clinical Use
NSAID:
Treatment of migraine
Synthesis
Tolfenamic acid is obtained by
condensation of 2-chlorobenzoic acid with 3-
chloro-2-methyl-phenylamine using CuBr2 in
diethylenglycol dimethyl ether .
Veterinary Drugs and Treatments
Tolfenamic acid may be useful for the treatment of acute or chronic pain and/or inflammation in dogs and acute pain/inflammation in cats. In Europe, it is also approved for use in cattle.
Drug interactions
Potentially hazardous interactions with other drugs
ACE inhibitors and angiotensin-II antagonists:
antagonism of hypotensive effect; increased risk of
nephrotoxicity and hyperkalaemia.
Analgesics: avoid concomitant use of 2 or more
NSAIDs, including aspirin (increased side effects);
avoid with ketorolac (increased risk of side effects
and haemorrhage).
Antibacterials: possibly increased risk of convulsions
with quinolones.
Anticoagulants: effects of coumarins and
phenindione enhanced; possibly increased risk of
bleeding with heparins, dabigatran and edoxaban.
Antidepressants: increased risk of bleeding with
SSRIs and venlafaxine.
Antidiabetic agents: effects of sulphonylureas enhanced.
Antiepileptics: possibly increased phenytoin
concentration.
Antivirals: increased risk of haematological toxicity
with zidovudine; concentration possibly increased by
ritonavir.
Ciclosporin: may potentiate nephrotoxicity.
Cytotoxics: reduced excretion of methotrexate;
increased risk of bleeding with erlotinib.
Diuretics: increased risk of nephrotoxicity;
antagonism of diuretic effect; hyperkalaemia with
potassium-sparing diuretics.
Lithium: excretion decreased.
Pentoxifylline: increased risk of bleeding.
Tacrolimus: increased risk of nephrotoxicity
Metabolism
Tolfenamic acid is metabolised in the liver; the metabolites and unchanged drug are conjugated with glucuronic acid. About 90
% of an ingested dose is excreted in the urine and the remainder in the faeces.
References
[1] Patent: CN104557584, 2016, B. Location in patent: Paragraph 0016; 0017; 0018
Tolfenamic acid Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Yanxi Chemical Co., Ltd. | +8618531123677 | faithe@yan-xi.com | China | 5853 | 58 |
| Hebei Dangtong Import and export Co LTD | +86-86-4001020630 +8619831957301 | admin@hbdangtong.com | China | 1000 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531151365 | mina@chuanghaibio.com | China | 18126 | 58 |
| airuikechemical co., ltd. | +86-18353166132 | sales02@airuikechemical.com | China | 983 | 58 |
| Shaanxi TNJONE Pharmaceutical Co., Ltd | +8618092446649 | sarah@tnjone.com | China | 1143 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29640 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21590 | 55 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418679 +8618949832763 | info@tnjchem.com | China | 2988 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29819 | 58 |
| Shandong chuangyingchemical Co., Ltd. | 18853181302 | sale@chuangyingchem.com | CHINA | 5906 | 58 |
View Lastest Price from Tolfenamic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-05-01 | Tolfenamic acid
13710-19-5
|
US $0.00 / kg | 1kg | 98% | Customise | Hefei Lbao Physical & Chemical Science Co.,Ltd | |
 |
2026-04-22 | Tolfenamic Acid
13710-19-5
|
US $30.00 / mL | 99.74% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-04-22 | Tolfenamic Acid
13710-19-5
|
US $30.00 / mL | 99.74% | 10g | TargetMol Chemicals Inc. |
-
- Tolfenamic acid
13710-19-5
- US $0.00 / kg
- 98%
- Hefei Lbao Physical & Chemical Science Co.,Ltd
-
- Tolfenamic Acid
13710-19-5
- US $30.00 / mL
- 99.74%
- TargetMol Chemicals Inc.
-
- Tolfenamic Acid
13710-19-5
- US $30.00 / mL
- 99.74%
- TargetMol Chemicals Inc.
