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ChemicalBook >> CAS DataBase List >>2-CHLORO-7H-PYRROLO[2,3-D]PYRIMIDINE

2-CHLORO-7H-PYRROLO[2,3-D]PYRIMIDINE

2-CHLORO-7H-PYRROLO[2,3-D]PYRIMIDINE Structure
2-CHLORO-7H-PYRROLO[2,3-D]PYRIMIDINE structure
CAS No.
335654-06-3
Chemical Name:
2-CHLORO-7H-PYRROLO[2,3-D]PYRIMIDINE
Synonyms
SW-114;SWF-114;2-CHLORO-7H-PYRROLO[2;2-Chloro-7-deazapurine;2-Chloro-7H-pyrrolo[2,3-d...;2-CHLORO-7H-PYRROLO[2,3-D]PYRIMIDINE;2-Chloro-1H-pyrrolo[2,3-d]pyrimidine;7H-Pyrrolo[2,3-d]pyriMidine,2-chloro-;1H-Pyrrolo[2,3-d]pyrimidine, 2-chloro-;2-Chloro-7H-pyrrolo[2,3-d]pyrimidine 95%
CBNumber:
CB6385730
Molecular Formula:
C6H4ClN3
Molecular Weight:
153.57
MDL Number:
MFCD07787392
MOL File:
335654-06-3.mol
MSDS File:
SDS
Last updated:2026-05-28 04:38:53
Product description Number Pack Size Price
2-Chloro-7H-pyrrolo[2,3-d]pyrimidine AldrichCPR ANV00113 1 g $304
2-Chloro 7H-Pyrrolo[2,3-d]pyrimidine Asreported 267651 500mg $360
2-Chloro 7H-Pyrrolo[2,3-d]pyrimidine Asreported 267651 1g $505
2-Chloro 7H-Pyrrolo[2,3-d]pyrimidine Asreported 267651 2g $686
2-Chloro 7H-Pyrrolo[2,3-d]pyrimidine Asreported 267651 5g $1055
More product size
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2-CHLORO-7H-PYRROLO[2,3-D]PYRIMIDINE Properties

Density 1.531±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
form solid
pka 11.18±0.50(Predicted)
Appearance Off-white to light brown Solid
InChI InChI=1S/C6H4ClN3/c7-6-9-3-4-1-2-8-5(4)10-6/h1-3H,(H,8,9,10)
InChIKey HJOQGBBHVRYTDX-UHFFFAOYSA-N
SMILES C1(Cl)=NC=C2C=CNC2=N1
UNSPSC Code 12352200
NACRES NA.21

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
Hazard Codes  Xi,T
Risk Statements  25
Safety Statements  45-24/25
RIDADR  UN2811
WGK Germany  WGK 3
Hazard Note  Irritant
HS Code  29339900
Storage Class 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects
Hazard Classifications Acute Tox. 3 Oral

2-CHLORO-7H-PYRROLO[2,3-D]PYRIMIDINE price More Price(96)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich ANV00113 2-Chloro-7H-pyrrolo[2,3-d]pyrimidine AldrichCPR 1 g $304 2026-04-30 Buy
Usbiological 267651 2-Chloro 7H-Pyrrolo[2,3-d]pyrimidine Asreported 335654-06-3 500mg $360 2026-06-03 Buy
Usbiological 267651 2-Chloro 7H-Pyrrolo[2,3-d]pyrimidine Asreported 335654-06-3 1g $505 2026-06-03 Buy
Usbiological 267651 2-Chloro 7H-Pyrrolo[2,3-d]pyrimidine Asreported 335654-06-3 2g $686 2026-06-03 Buy
Usbiological 267651 2-Chloro 7H-Pyrrolo[2,3-d]pyrimidine Asreported 335654-06-3 5g $1055 2026-06-03 Buy
Product number Packaging Price Buy
ANV00113 1 g $304 Buy
267651 500mg $360 Buy
267651 1g $505 Buy
267651 2g $686 Buy
267651 5g $1055 Buy

2-CHLORO-7H-PYRROLO[2,3-D]PYRIMIDINE Chemical Properties,Uses,Production

Uses

An intermediate pyrrolo-pyrimidine compound, 2-Chloro-7H-pyrrolo[2,3-d]pyrimidine can be used in the preparation of tyrosine kinase inhibitors, particularly oral signal transducers and activators of transcription 6 (STAT6) inhibitors.

Uses

An intermediate pyrrolo-pyrimidine compound used in the preparation of tyrosine kinase inhibitors, particularly oral signal transducers and activators of transcription 6 (STAT6) inhibitors.

Synthesis

2,4-DICHLORO-7H-PYRROLO2,3-DPYRIMIDINE

90213-66-4

2-CHLORO-7H-PYRROLO[2,3-D]PYRIMIDINE

335654-06-3

The general procedure for the synthesis of 2-chloro-7H-pyrrolo[2,3-d]pyrimidines from 2,4-dichloro-7H-pyrrolo[2,3-d]pyrimidines is as follows: zinc powder (8700.0 g, 133 mol, 10.0 eq.) was added in batches to glacial acetic acid (3.3 L, 53.2 mol, 4.0 eq.), followed by addition of acetonitrile (30.0 L) to form a reaction mixture. The reaction mixture was cooled to 25 °C and then filtered. The filtrate was concentrated under reduced pressure and then added to 30 L of ice water to precipitate the product. The mixture was warmed to 80 °C and kept at this temperature for 14 hours. Upon completion of the reaction, a pink solid was obtained. The solid was collected by filtration and the cake was washed with water (5 L x 3 times) and dried to give 1501.7 g of white solid in 73.54% yield.

References

[1] Patent: CN105949196, 2016, A. Location in patent: Paragraph 0044; 0065; 0083-0087
[2] Patent: CN105859726, 2016, A. Location in patent: Paragraph 0030; 0031; 0032
[3] Patent: WO2010/7116, 2010, A2. Location in patent: Page/Page column 91-92
[4] Patent: WO2010/7114, 2010, A2. Location in patent: Page/Page column 125-126
[5] Patent: JP2016/124825, 2016, A

2-CHLORO-7H-PYRROLO[2,3-D]PYRIMIDINE Preparation Products And Raw materials

Raw materials

5-Bromo-2,4-dichloropyrimidine N,N-Dimethylformamide Tetraethylammonium Chloride Toluene Potassium carbonate
Tetrakis(triphenylphosphine)palladium Tetrahydrofuran Ethyl acetate Hydrochloric acid Methanol
Sodium hydroxide 1-Ethoxy-2-(tributylstannyl)ethene Bis(triphenylphosphine)palladium(II) chloride Ethoxyethyne Ammonia

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Preparation Products

2-Chloro-7-methyl-7H-pyrrolo[2,3-d]pyrimidine 5-Bromo-2-chloro-7H-pyrrolo[2,3-d]pyrimidine

2-CHLORO-7H-PYRROLO[2,3-D]PYRIMIDINE Suppliers

Global( 212)Suppliers
Supplier Tel Email Country ProdList Advantage
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 20122 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29640 60
Shanghai Daken Advanced Materials Co.,Ltd 		+86-2158073036 info@dakenam.com China 13901 58
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29815 58
Jinan Carbotang Biotech Co.,Ltd. 		+8615866703830 figo.gao@foxmail.com China 8497 58
Accela ChemBio Inc. 		+1-858-6993322 info@accelachem.com United States 21193 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49979 58
Shaanxi Dideu Medichem Co. Ltd 		+86-029-81138252 +86-173 9270 1263 1057@dideu.com China 3997 58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		+8613580539051 joe@yuhengpharm.com CHINA 21142 58
Supplier Advantage
Henan Fengda Chemical Co., Ltd 		58
Capot Chemical Co.,Ltd. 		60
Shanghai Daken Advanced Materials Co.,Ltd 		58
career henan chemical co 		58
Jinan Carbotang Biotech Co.,Ltd. 		58
Accela ChemBio Inc. 		58
Alchem Pharmtech,Inc. 		58
CONIER CHEM AND PHARMA LIMITED 		58
Shaanxi Dideu Medichem Co. Ltd 		58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		58

View Lastest Price from 2-CHLORO-7H-PYRROLO[2,3-D]PYRIMIDINE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-CHLORO-7H-PYRROLO[2,3-D]PYRIMIDINE pictures 2025-09-25 2-CHLORO-7H-PYRROLO[2,3-D]PYRIMIDINE
335654-06-3
 $1.10-32.00 1kg 99% Henan Fengda Chemical Co., Ltd
2-Chloro-7H-pyrrolo[2,3-d]pyrimidine pictures 2022-01-27 2-Chloro-7H-pyrrolo[2,3-d]pyrimidine
335654-06-3
 1KG 97.3% 100 tons Honest Joy Holdings Limited
2-Chloro-7H-pyrrolo[2,3-d]pyrimidine pictures 2021-07-13 2-Chloro-7H-pyrrolo[2,3-d]pyrimidine
335654-06-3
 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd

2-CHLORO-7H-PYRROLO[2,3-D]PYRIMIDINE Spectrum

2-CHLORO-7H-PYRROLO[2,3-D]PYRIMIDINE(335654-06-3)1HNMR

335654-06-3(2-CHLORO-7H-PYRROLO[2,3-D]PYRIMIDINE)Related Search:

5-FLUORO-4-IODO-1H-PYRROLO[2,3-B]PYRIDINE 3,6-Dichloro-4-methylpyridazine Methyl 7-azaindole-6-carboxylate methyl 6‐bromo‐2‐oxo‐2,3‐dihydro‐1h‐indole‐4‐carboxylate 4-AMINO-1-[(2,4-DIMETHOXYPHENYL)METHYL]PYRROLIDIN-2-ONE
4-(TERT-BUTOXYCARBONYL)PHENYLBORONIC ACID 6-Chloro-5-fluoro-7-azaindole 5-FLUORO-1H-PYRROLO[2,3-B]PYRIDINE 7-BroMo-2-(Methylthio)pyrrolo[1,2-f][1,2,4]triazine 1H-Pyrrolo[2,3-b]pyridine, 3-bromo-1-[(4-methylphenyl)sulfonyl]-
7-Bromopyrido[3,2-d]pyrimidin-4(3H)-one [1-(trifluoromethyl)cyclopropyl]methanamine hydrochloride 5,7-Difluoroindole 5,6-dichloro-1H-Indole-3-carboxaldehyde 6-Nitroindole
3-Chloro-6-iodopyridazine 1-(Trifluoromethyl)cyclopropanemethanol N/A

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2-CHLORO-7H-PYRROLO[2,3-D]PYRIMIDINE 2-Chloro-7H-pyrrolo[2,3-d]pyrimidine 95% 1H-Pyrrolo[2,3-d]pyrimidine, 2-chloro- 2-Chloro-1H-pyrrolo[2,3-d]pyrimidine 2-Chloro-7H-pyrrolo[2,3-d... 2-Chloro-7-deazapurine 7H-Pyrrolo[2,3-d]pyriMidine,2-chloro- 2-CHLORO-7H-PYRROLO[2 SWF-114 SW-114 335654-06-3 Heterocycle-Pyrimidine series Amines Bases & Related Reagents Intermediates Nucleotides Tyrosine Kinase Inhibitors